Results 71 to 80 of about 3,871 (146)
Animal Models and Experimental Medicine, EarlyView.Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou +4 more
wiley +1 more source
OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes
, 2017 OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control ...
Chu, Dinh Toi +5 more
core +1 more source
Food Chemistry International, EarlyView.The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi +2 more
wiley +1 more source
The Role of ATAD3A and SLC25 Proteins in OPA1 Function
, 2014 OPA1 regulates cristae structure and mitochondrial DNA (mtDNA) maintenance. Recently, our lab identified ATAD3A and SLC25 proteins as OPA1 interactors.
Wong, Jacob
core +2 more sources
Bioenergetic analysis of Opa1 morphants.
, 2013 Oxygen consumption rates (OCR) were measured in 24, 48, and 72 hpf morphants (mean +/− SEM, n = 5–10). A. Opa1 morphant basal respiration was significantly decreased compared to MMC morphants at 24 and 72 hpf (p = 0.004 (a) and p = 0.0007 (b ...
Sherine S. L. Chan (343065) +2 more
core +1 more source
Optic atrophy 1 (OPA1) is essential for NET formation and antibacterial functions in neutrophils [PDF]
, 2016 The precise nature of anti-bacterial and anti-fungal inflammatory responses has not yet been completely defined. Besides intracellular killing, neutrophils are able to exert an antibacterial effect in the extracellular space by forming so-called ...
Amini, Poorya
core
Differentiation activates mitochondrial OPA1 processing in myoblast cell lines [PDF]
Mitochondrial optic atrophy-1 (OPA1) plays key roles in adapting mitochondrial structure to bioenergetic function. When transmembrane potential across the inner membrane (Δψm) is intact, long (L-OPA1) isoforms shape the inner membrane through membrane ...
Elizondo, Jorge +10 more
core +1 more source
Cell Death and DiseaseIn breast cancer, the inner mitochondrial membrane fusion protein Optic Atrophy 1 (OPA1) is upregulated and its inhibition reverses acquired chemoresistance. However, it remains unclear whether OPA1 inhibition also targets normal breast cells.
Antigoni Diokmetzidou +5 more
doaj +1 more source
CellsDominant optic atrophy (DOA) is the most commonly inherited optic neuropathy. The majority of DOA is caused by mutations in the OPA1 gene, which encodes a dynamin-related GTPase located to the mitochondrion.
Katherine A. Pohl +5 more
doaj +1 more source