Results 91 to 100 of about 3,871 (146)

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

HSPE1 deficiency underlies the crosstalk between metabolic dysfunction‐associated steatotic liver disease and age‐related macular degeneration

VIEW, EarlyView.
Rare‐earth ions act as multifunctional modifiers in perovskite solar cells by improving charge transport, suppressing oxygen vacancies, passivating defects, promoting grain growth, and enabling redox‐mediated stabilization. In addition, RE‐doped layers can expand spectral utilization through upconversion and downconversion, thereby enhancing light ...
Jiaqi Meng, Alimire Maihemuti, Yuan Yuan, Chao Chen, Mengchao Zhu, Hao Wang, Furong Zhu, Zhaodi Che, Jia Xiao, Xiangjia Zhu   +9 more
wiley   +1 more source

Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to ADOA pathogenesis.: OPA1: mitochondrial morphology, apoptosis, and optic atrophy

, 2007
To characterize the molecular links between type-1 autosomal dominant optic atrophy (ADOA) and OPA1 dysfunctions, the effects of pathogenic alleles of this dynamin on mitochondrial morphology and apoptosis were analyzed, either in fibroblasts from ...
Arnauné-Pelloquin, Laetitia, Hamel, Christian, P., Amati-Bonneau, Patrizia, Emorine, Laurent, J., Mils, Valérie, Landes, Thomas, Bonneau, Dominique, Guichet, Agnès, Olichon, Aurélien, Lenaers, Guy, Reynier, Pascal, Belenguer, Pascale, Delettre, Cécile   +12 more
core   +1 more source

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Circadian behaviour in Opa1^+/+ and Opa1^+/− mice.

, 2013
Representative actograms from (A) Opa1 +/+ and (B) Opa1 +/− mice entrained to a 12/12 LD cycle and subsequently released into constant darkness (DD). Each horizontal line corresponds to one day and the data has been double plotted.
Georgia Perganta (284129), Christiana Katti (173404), Athanasios Vachtsevanos (284131), Robert E. MacLaren (170328), Marcela Votruba (284133), Alun R. Barnard (284130), Sumathi Sekaran (173416), Ron H. Douglas (284132)   +7 more
core   +1 more source

Gene structure and chromosomal localization of mouse Opa1 : its exclusion from the Bst locus

BMC Genetics, 2003
Background Autosomal dominant optic atrophy type 1 (DOA) is the most common form of hereditary optic atrophy in human. We have previously identified the OPA1 gene and shown that it was mutated in patients with DOA.
Belenguer Pascale, Delettre Cécile, Lenaers Guy, Hamel Christian P   +3 more
doaj   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Pupil light reflex in Opa1^+/+ and Opa1^+/− mice.

, 2013
The average minimum pupil area expressed as a percentage of maximum dilation following illumination with various intensities of white light for Opa1+/+ (n = 5) and Opa1+/− (n = 5) mice. All data are fitted with four term sigmoidal functions (solid lines)
Georgia Perganta (284129), Christiana Katti (173404), Athanasios Vachtsevanos (284131), Robert E. MacLaren (170328), Marcela Votruba (284133), Alun R. Barnard (284130), Sumathi Sekaran (173416), Ron H. Douglas (284132)   +7 more
core   +1 more source