Results 91 to 100 of about 15,870 (189)
The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan
Taiwan Journal of Ophthalmology, 2018 PURPOSE: The purpose of this research is to evaluate the relationship between of optic atrophy 1 (OPA1) polymorphism and normal tension glaucoma (NTG) by surveying patients from central Taiwan. This study finding could help us to understand the impact of
Yan-Ting Chen, San-Ni Chen, Chin-San Liu
doaj +1 more source
Clinical Genetics, EarlyView.Opticus atrophy—Genetic testing with WES/WGS in 62 patients with optic atrophy provided a genetic diagnosis in 21 patients (33.9%). 42.9% of these involved non‐OPA1 genes, including WFS1, ACO2, NR2F1, UCHL1, CACNA1F, and COQ2, where the genetic diagnosis prompted additional clinical evaluation, surveillance, or therapeutic intervention.
Katrine M. Johannesen +9 more
wiley +1 more source
Circadian behaviour in Opa1+/+ and Opa1+/− mice.
, 2013 Representative actograms from (A) Opa1 +/+ and (B) Opa1 +/− mice entrained to a 12/12 LD cycle and subsequently released into constant darkness (DD). Each horizontal line corresponds to one day and the data has been double plotted.
Georgia Perganta (284129) +7 more
core +1 more source
Cell Proliferation, EarlyView.In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang +8 more
wiley +1 more source
Pupil light reflex in Opa1+/+ and Opa1+/− mice.
, 2013 The average minimum pupil area expressed as a percentage of maximum dilation following illumination with various intensities of white light for Opa1+/+ (n = 5) and Opa1+/− (n = 5) mice. All data are fitted with four term sigmoidal functions (solid lines)
Georgia Perganta (284129) +7 more
core +1 more source
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
The FEBS Journal, EarlyView.Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma +1 more
wiley +1 more source
, 2007 To characterize the molecular links between type-1 autosomal dominant optic atrophy (ADOA) and OPA1 dysfunctions, the effects of pathogenic alleles of this dynamin on mitochondrial morphology and apoptosis were analyzed, either in fibroblasts from ...
Arnauné-Pelloquin, Laetitia +12 more
core +1 more source
The Role of OPA1 and Interacting Proteins in Mitochondrial Function
, 2015 The cell possesses a number of vital mechanisms to respond to different stressors. Mitochondria are dynamic organelles which undergo constant changes in length, transport and inner membrane structure and curvature.
Patten, David A
core +2 more sources
Optimization of photobiomodulation therapy for spinal cord injury: A review
Photochemistry and Photobiology, EarlyView.Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew +3 more
wiley +1 more source