Results 111 to 120 of about 15,870 (189)

Herstellung und Analyse von OPA1 (Optische Atrophie 1) defizienten Mäusen

, 2007
TITLE, ACKNOWLEDGEMENTS AND CONTENTS INTRODUCTION 1 MATERIALS AND METHODS 17 RESULTS 39 DISCUSSION 68 SUMMARY 88 ZUSAMMENFASSUNG 90 BIBLIOGRAPHY 92 PUBLICATIONS 111 APPENDIX 115 EIDESSTATTLICHE ERKLÄRUNG 120Optic atrophy 1 (OPA1) is a
Fiket, Maja
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Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Clinical Features of OPA1-Related Optic Neuropathy

, 2015
Dominant optic atrophy (DOA) is the most common hereditary optic neuropathy, and known mutations in OPA1 account for 40-60% of cases. Previous studies investigating clinical features in DOA patients with OPA1 mutations have been limited to a few ...
Eric D. Gaier; Katherine Boudreault; Isao Nakata; Maria Janessian; Elizabeth Delbono; Simmons Lessell; Dean Cestari; Janey L. Wiggs; Joseph F. Rizzo, Eric D Gaier, MD; Katherine Boudreault, MD; Isao Nakata, MD; Maria Janessian; Elizabeth Delbono, MD; Simmons Lessell, MD (1933 - 2016); Dean Cestari; Janey L. Wiggs; Joseph F. Rizzo III, MD   +1 more
core  

Differentiation activates mitochondrial OPA1 processing in myoblast cell lines

Mitochondrial optic atrophy-1 (OPA1) plays key roles in adapting mitochondrial structure to bioenergetic function. When transmembrane potential across the inner membrane (Δψm) is intact, long (L-OPA1) isoforms shape the inner membrane through membrane ...
Elizondo, Jorge, Keniry, Megan, Ramos, Isaiah, Carrillo, Omar, Lopez, Alma, St. Vallier, Shaynah, De la Torre, Patrick, Gilkerson, Robert, Kaur, Harpreet, Garcia, Iraselia, Bazan, Daniela   +10 more
core   +1 more source

Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females

BMC Cancer
Background Skeletal muscle atrophy during cancer-induced cachexia remains a significant challenge in cancer management. Mitochondrial defects precede muscle mass and functional losses in models of cancer cachexia (CC).
Francielly Morena, Seongkyun Lim, Ana Regina Cabrera, Toby L. Chambers, Pieter J. Koopmans, Stavroula Tsitkanou, Sabin Khadgi, Calvin Peterson, Eleanor R. Schrems, Ruqaiza Muhyudin, Sepideh Shakeri, Kevin Zhao, Devan Mishra, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +15 more
doaj   +1 more source

Gene structure and chromosomal localization of mouse Opa1 : its exclusion from the Bst locus

BMC Genetics, 2003
Background Autosomal dominant optic atrophy type 1 (DOA) is the most common form of hereditary optic atrophy in human. We have previously identified the OPA1 gene and shown that it was mutated in patients with DOA.
Belenguer Pascale, Delettre Cécile, Lenaers Guy, Hamel Christian P   +3 more
doaj   +1 more source

Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart

The Journal of Physiology, EarlyView.
Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Ashley S. Meakin, Mitchell C. Lock, Jordan A. Minns, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison   +10 more
wiley   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Biogenese des Dynamin-ähnlichen Proteins OPA1 in Mitochondrien [PDF]

, 2008
Die autosomal dominante Optikusatrophie ist mit Mutationen in dem Gen OPA1 assoziiert. OPA1 kodiert eine konservierte mitochondriale Dynamin-ähnliche GTPase. Das Ortholog von OPA1 in S. cerevisiae ist Mgm1.
Wagener, Johannes
core  

Investigation of OPA1 in Mitochondrial Dynamics and Ultrastructure [PDF]

Mitochondria are highly dynamic organelles with a complex ultrastructure. The mitochondrial inner membrane (MIM) is folded into cristae in which oxidative phosphorylation, a process to generate energy for the cell, takes place.
Stuut, Christiaan
core   +1 more source