Results 131 to 140 of about 15,870 (189)

Biochemical and cell biological analysis of OPA1 GTPase mutants

, 2008
Die Optikus Atrophie 1 (OPA1) ist ein mitochondriales Protein, das zwischen der inneren und äußeren Mitochondrienmembran lokalisiert ist. Mutationen im OPA1-Gen wurden in Patienten mit autosomal dominanter Optikus Atrophie (adOA) gefunden.
Bulczak, Anita
core   +1 more source

The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice

Nature Communications
Recent studies have highlighted the importance of mitochondria in NP cells and articular chondrocyte health. Since the understanding of mechanisms governing mitochondrial dynamics in these tissues is lacking, we investigated the role of OPA1, a ...
Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige K. Boneski, Hiromi Sesaki, Ruteja A. Barve, John A. Collins, Makarand V. Risbud   +10 more
doaj   +1 more source

Mitochondrial dynamics and disease, OPA1

, 2006
The mitochondria are dynamic organelles that constantly fuse and divide. An equilibrium between fusion and fission controls the morphology of the mitochondria, which appear as dots or elongated tubules depending the prevailing force.
Arnauné-Pelloquin, Laetitia, Amati-Bonneau, Patrizia, Guillou, Emmanuelle, Mils, Valérie, Daloyau, Marlène, Landes, Thomas, Hamel, Christian, Bonneau, Dominique, Olichon, Aurélien, Lenaers, Guy, Reynier, Pascal, Belenguer, Pascale, Emorine, Laurent J., Delettre, Cécile   +13 more
core   +1 more source

Cristae: bridging bioenergetic hubs and compartmental barriers in mitochondrial homeostasis. [PDF]

Cell Death Dis
Rao J, Wan QQ, Chen L, Tang RB, Killedar D, Tay F, Niu LN.   +6 more
europepmc   +1 more source

IL-15 Links Muscle-Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy. [PDF]

J Cachexia Sarcopenia Muscle
Li Y, Rao J, Lai W, Sun Y, Lin H, Zhang J, Ye Z, Hu Z, Peng H.   +8 more
europepmc   +1 more source

Frequency and Hearing Loss Phenotypes of <i>OPA1</i> Variants in a Cohort of 18,475 Patients with Hearing Impairment. [PDF]

Genes (Basel)
Kawakita M, Moteki H, Nishio SY, Kobayashi Y, Adachi M, Okano T, Yamazaki H, Nakayama J, Ohira S, Ishino T, Takumi Y, Usami SI.   +11 more
europepmc   +1 more source

The role of mitochondrial dynamics in metabolic dysfunction-associated steatotic liver disease. [PDF]

Front Med (Lausanne)
Yang N, Hao Y.
europepmc   +1 more source

Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class. [PDF]

Invest Ophthalmol Vis Sci
Schrittwieser J, Reitner A, Kircher K, Bertich M, Stapf C, Lilja SV, Paquay A, Reiter GS, Bittner RE, Schmidt WM, Pemp B.   +10 more
europepmc   +1 more source

Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions. [PDF]

Mol Med Rep
Xie C, Liu Z, Chen T, Lu H, Zhang X, Yu W, Zhang J, Shang D, Wang X.   +8 more
europepmc   +1 more source

OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration. [PDF]

JACC Basic Transl Sci
Ronfini M, Prando V, Di Mauro V, Dokshokova L, Lazzeri E, Costantini I, Alàn L, Riviere EA, Incensi A, Olianti C, La Morgia C, Liguori R, Sacconi L, Donadio V, Scorrano L, Carelli V, Mongillo M, Zaglia T.   +17 more
europepmc   +1 more source