Results 121 to 130 of about 15,870 (189)
Hypoxia‐induced vulnerability of the somatosensory nervous system
The Journal of Physiology, EarlyView.Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend PoWeR training (11.5 weeks of voluntary wheel running with progressively increased resistance) before and during cancer attenuates muscle loss, limits tumour growth, drives a transition toward a more oxidative muscle phenotype (IIB‐to‐IIA shift), downregulates cachexia‐associated pathways and enhances mitochondrial performance in
Stavroula Tsitkanou +13 more
wiley +1 more source
Physiological ReportsCardiovascular diseases are the major cause of death worldwide, and their frequency increases with age in association with kidney damage. As a reduction in fusion protein optic atrophy type 1 (Opa1) level in endothelial cells (ECs) decreases the vascular
Carlotta Turnaturi +11 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend This study used a non‐targeted proteomic approach to explore the skeletal muscle determinants of peak fat oxidation (PFO) and the exercise intensity at which this occurs (Fatmax). Comprehensive physiological phenotyping was completed in young, lean, physically active males, including blood and skeletal muscle sampling.
Eloise K. Tarry +11 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Hypoxia results in fragmented mitochondria. Whether this fragmentation promotes or prevents cell death is unresolved. Caenorhabditis elegans mutants defective in mitochondrial fission and fusion coupled with a hypoxia resistant Raptor mutant demonstrated that hypoxia‐induced mitochondrial fragmentation occurs without an intact fission machinery and ...
Julien Goldstick +4 more
wiley +1 more source
OPA1: How much do we know to approach therapy?
, 2018 OPA1 is a GTPase that controls several functions, such as mitochondrial dynamics and energetics, mtDNA maintenance and cristae integrity. In the last years, there have been described other cellular pathways and mechanisms involving OPA1 directly or ...
V. Del Dotto +17 more
core +1 more source
OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution
Cell Death and DiseaseOptic atrophy protein 1 (OPA1) mediates inner mitochondrial membrane (IMM) fusion and cristae organization. Mutations in OPA1 cause autosomal dominant optic atrophy (ADOA), a leading cause of blindness.
J. Macuada +11 more
doaj +1 more source
Opa1+/- left-ventricular cardiomyocyte AP.
, 2016 A: Typical AP recorded using whole-cell patch-clamp technique with current clamp at 1Hz in WT (black) and Opa1+/- (red) isolated left-ventricular cardiomyocytes.
Jérémy Fauconnier (586768) +17 more
core +1 more source
iScienceSummary: Myogenic differentiation is integral for the regeneration of skeletal muscle following tissue damage. Though high-energy post-mitotic muscle relies predominantly on mitochondrial respiration, the importance of mitochondrial remodeling in ...
Matthew Triolo +5 more
doaj +1 more source
Exacerbated reduction of OPA1 and MFN2 in ischemic 5xFAD mice.
, 2015 (A) The expression levels of long OPA1 isoform (OPA1-L) and short OPA1 isoform (OPA1-S) were substantially reduced in brain mitochondria from ischemic 5xFAD mice; while the ratio of OPA1-L to OPA1-S remained unchanged ...
Neha Tandon (833506) +9 more
core +1 more source