Results 101 to 110 of about 3,871 (146)

M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction.
Lei Li, Hongmei Liu, Yu Mao, Huanhuan Wang, Lige Song, Zhiqiang Kang   +5 more
wiley   +1 more source

Clinical Features of OPA1-Related Optic Neuropathy

, 2015
Dominant optic atrophy (DOA) is the most common hereditary optic neuropathy, and known mutations in OPA1 account for 40-60% of cases. Previous studies investigating clinical features in DOA patients with OPA1 mutations have been limited to a few ...
Eric D. Gaier; Katherine Boudreault; Isao Nakata; Maria Janessian; Elizabeth Delbono; Simmons Lessell; Dean Cestari; Janey L. Wiggs; Joseph F. Rizzo, Eric D Gaier, MD; Katherine Boudreault, MD; Isao Nakata, MD; Maria Janessian; Elizabeth Delbono, MD; Simmons Lessell, MD (1933 - 2016); Dean Cestari; Janey L. Wiggs; Joseph F. Rizzo III, MD   +1 more
core  

Phase shift behaviour in Opa1^+/+ and Opa1^+/− mice.

, 2013
Representative actograms from (A) Opa1+/+ and (B) Opa1+/− mice in constant dark (DD) conditions. Animals were exposed to 15 min light pulses every ∼15 days.
Georgia Perganta (284129), Christiana Katti (173404), Athanasios Vachtsevanos (284131), Robert E. MacLaren (170328), Marcela Votruba (284133), Alun R. Barnard (284130), Sumathi Sekaran (173416), Ron H. Douglas (284132)   +7 more
core   +1 more source

OPA1: How much do we know to approach therapy? [PDF]

, 2018
OPA1 is a GTPase that controls several functions, such as mitochondrial dynamics and energetics, mtDNA maintenance and cristae integrity. In the last years, there have been described other cellular pathways and mechanisms involving OPA1 directly or ...
V. Del Dotto, Del Dotto, Valentina, Rugolo, Michela, V. Carelli, M. Rugolo, Guy Lenaers, Valerio Carelli, C. Zanna, Fogazza, Mario, Carelli, Valerio, Lenaers, Guy, Mario Fogazza, Michela Rugolo, Claudia Zanna, Valentina Del Dotto, Zanna, Claudia, M. Fogazza, G. Lenaers   +17 more
core   +1 more source

Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females

BMC Cancer
Background Skeletal muscle atrophy during cancer-induced cachexia remains a significant challenge in cancer management. Mitochondrial defects precede muscle mass and functional losses in models of cancer cachexia (CC).
Francielly Morena, Seongkyun Lim, Ana Regina Cabrera, Toby L. Chambers, Pieter J. Koopmans, Stavroula Tsitkanou, Sabin Khadgi, Calvin Peterson, Eleanor R. Schrems, Ruqaiza Muhyudin, Sepideh Shakeri, Kevin Zhao, Devan Mishra, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +15 more
doaj   +1 more source

Mapping the Bioenergetic Landscape of Oral Cancer Stem Cells: A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Objectives Oral squamous cell carcinoma (OSSC) remains highly lethal, with resistance largely driven by cancer stem cells (CSCs). Mitochondrial reprogramming supports CSC redox control, self‐renewal, and survival. This systematic review aimed to synthesize mitochondrial mechanisms sustaining CSCs in OSCC and evaluate their therapeutic ...
Rodrigo Elísio de Sá, Rebeca Barbosa da Rocha, Benedito dos Santos Alves, Maria Eduarda de Araujo de Carvalho, Jayane da Silva Sousa, José Delano Barreto Marinho‐Filho, Ana Jérsia Araújo   +6 more
wiley   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

MICOS und OPA1: Architekten mitochondrialer Membransysteme [PDF]

Mitochondrien werden aufgrund ihrer evolutionären Abstammung von α-Proteobakterien von zwei Membranen ummantelt. Die innere Mitochondrienmembran kann wiederum in die innere Grenzmembran und die in die Matrix ragenden Cristae-Membranen unterteilt werden ...
Graf, Nadine
core   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source

PINK1‐Associated Juvenile‐Onset Parkinsonism: Marked Phenotypic Variability and Limited Genotype–Phenotype Correlation

Movement Disorders, EarlyView.
Reza Maroofian, Ross Leng, Shilpan G. Patel, Hina Ojha, Heba Hosny, Maha Zaki, Miratul M.K. Muqit, Henry Houlden   +7 more
wiley   +1 more source