Results 81 to 90 of about 3,871 (146)

Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma

Frontiers in Molecular Neuroscience, 2018
Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs). Increasing evidences have revealed that impaired mitochondrial dynamics occurs early in neurodegenerative diseases.
Xinxin Hu, Xinxin Hu, Xinxin Hu, Xinxin Hu, Yi Dai, Yi Dai, Yi Dai, Yi Dai, Rong Zhang, Rong Zhang, Rong Zhang, Kunte Shang, Kunte Shang, Kunte Shang, Kunte Shang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun   +19 more
doaj   +1 more source

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Biogenese des Dynamin-ähnlichen Proteins OPA1 in Mitochondrien [PDF]

, 2008
Die autosomal dominante Optikusatrophie ist mit Mutationen in dem Gen OPA1 assoziiert. OPA1 kodiert eine konservierte mitochondriale Dynamin-ähnliche GTPase. Das Ortholog von OPA1 in S. cerevisiae ist Mgm1.
Wagener, Johannes
core   +1 more source

Metabolic adaptations in liver-specific OPA1 knockout mice [PDF]

, 2020
[eng] OPA1 is a dynamin-related protein that is responsible for the fusion of the internal mitochondrial membrane and essential to control the morphology of the mitochondrial cristae.
Barros, Susana Raquel Costa
core   +2 more sources

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Integrated bioinformatic and in vivo analysis confirms the cardioprotective role of OPA1

BMC Cardiovascular Disorders
Background OPA1 is an inner mitochondrial membrane protein that mediates diverse signaling processes. OPA1 is important for cardiac function and protects against cardiac insults such as ischemia/reperfusion injury.
Claire Fong-McMaster, Serena M. Pulente, Luke S. Kennedy, Tyler K.T. Smith, Stephanie Myers, Michel N. Kanaan, Charbel Y. Karam, Matthew Cope, Michelle M. Levesque, Ella McIlroy, Ilka Lorenzen-Schmidt, Craig J. Goergen, Morgan D. Fullerton, Miroslava Cuperlovic-Culf, Erin E. Mulvihill, Mary-Ellen Harper   +15 more
doaj   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Molekulare Charakterisierung des Optischen Atrophie Proteins OPA1

, 2007
Title Table of contents Summary i Zusammenfassung ii 1\. Introduction 1 2\. Materials 17 3 Methods 23 4\. Results 39 5\. Discussion 63 6\. References 75 7\. Appendix 83The mitochondrion is an essential cytoplasmic organelle
Akepati, Vasudheva Reddy
core   +1 more source

The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan

Taiwan Journal of Ophthalmology, 2018
PURPOSE: The purpose of this research is to evaluate the relationship between of optic atrophy 1 (OPA1) polymorphism and normal tension glaucoma (NTG) by surveying patients from central Taiwan. This study finding could help us to understand the impact of
Yan-Ting Chen, San-Ni Chen, Chin-San Liu
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source