Results 81 to 90 of about 15,870 (189)
Activation of OPA1 Processing in Differentiated Myoblast Cells
, 2023 Mitochondria are eukaryotic cellular organelles that play a role in energy production, apoptosis, integrated stress response, and aging. Mitochondrial dynamics is the physical fusion (interconnection) and fission (fragmentation) of mitochondria within a ...
Carrillo, Omar Agustin
core
The Role of ATAD3A and SLC25 Proteins in OPA1 Function
, 2014 OPA1 regulates cristae structure and mitochondrial DNA (mtDNA) maintenance. Recently, our lab identified ATAD3A and SLC25 proteins as OPA1 interactors.
Wong, Jacob, Jacob Wong
core +2 more sources
GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao +10 more
wiley +1 more source
Molekulare Charakterisierung des Optischen Atrophie Proteins OPA1
, 2007 Title Table of contents Summary i Zusammenfassung ii 1\. Introduction 1 2\. Materials 17 3 Methods 23 4\. Results 39 5\. Discussion 63 6\. References 75 7\. Appendix 83The mitochondrion is an essential cytoplasmic organelle
Akepati, Vasudheva Reddy
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Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
CellsDominant optic atrophy (DOA) is the most commonly inherited optic neuropathy. The majority of DOA is caused by mutations in the OPA1 gene, which encodes a dynamin-related GTPase located to the mitochondrion.
Katherine A. Pohl +5 more
doaj +1 more source
Cell Death and DiseaseIn breast cancer, the inner mitochondrial membrane fusion protein Optic Atrophy 1 (OPA1) is upregulated and its inhibition reverses acquired chemoresistance. However, it remains unclear whether OPA1 inhibition also targets normal breast cells.
Antigoni Diokmetzidou +5 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs). Increasing evidences have revealed that impaired mitochondrial dynamics occurs early in neurodegenerative diseases.
Xinxin Hu +19 more
doaj +1 more source
Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy
Clinical Genetics, EarlyView.A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk +13 more
wiley +1 more source
OPA1-associated disorders: Phenotypes and pathophysiology
, 2009 The OPA1 gene, encoding a dynamin-like mitochondrial GTPase, is involved in autosomal dominant optic atrophy (ADOA, OMIM #165500). ADOA, also known as Kjer\u27s optic atrophy, affects retinal ganglion cells and the axons forming the optic nerve, leading ...
de Crescenzo, Marie-Anne +25 more
core +2 more sources