Results 61 to 70 of about 3,871 (146)

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Structural mechanism of mitochondrial membrane remodelling by human OPA1 [PDF]

, 2023
Distinct morphologies of the mitochondrial network support divergent metabolic and regulatory processes that determine cell function and fate1-3.
Malsburg, A., Matteo Dal Peraro, Sapp, Gracie M., Sapp, Gracie, Dal Peraro, Matteo, Zuccaro, K., Zuccaro, Kelly, Kelly E. Zuccaro, Aydin, H., Kalia, R., Laan, M., Moss, F., Kalia, Raghav, van der Laan, Martin, Halil Aydin, Alexander von der Malsburg, Raghav Kalia, Adam Frost, Peraro, M., Aydin, Halil, Zuccaro, Kelly E., Luciano A. Abriata, Gracie M. Sapp, Frost, Adam, Moss, Frank, Frost, A., Martin van der Laan, Bennett, J., Alexander von Appen, Bennett, Jeremy, von Appen, Alexander, Abriata, L., Abriata, Luciano, Sapp, G., Appen, A., Frank R. Moss, Jeremy A. Bennett, Abriata, Luciano Andres, von der Malsburg, Alexander, Moss, Frank R., Bennett, Jeremy A.   +40 more
core   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes

BMC Geriatrics, 2023
Background and aim DRP1 and OPA1 play important roles in mitochondrial fusion and fission. However, the role of DRP1 and OPA1 amplification in mitochondrial cognitive impairment has not been reported.
Mengqian Liu, Chen Gong, Xiaozhu Shen, Yi Jiang, Yiwen Xu, Wen Zhong, Yujiao Chen, Nan Dong, Jingxian Liao, Ning Yin   +9 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

OPA1-associated disorders: Phenotypes and pathophysiology [PDF]

, 2009
The OPA1 gene, encoding a dynamin-like mitochondrial GTPase, is involved in autosomal dominant optic atrophy (ADOA, OMIM #165500). ADOA, also known as Kjer\u27s optic atrophy, affects retinal ganglion cells and the axons forming the optic nerve, leading ...
de Crescenzo, Marie-Anne, D. Loiseau, Verny, Christophe, Ferré, Marc, V. Procaccio, Milea, Dan, A. Chevrollier, Procaccio, Vincent, Lenaers, Guy, V. Guillet, Gueguen, Naïg, Chevrollier, Arnaud, Amati-Bonneau, Patrizia, D. Bonneau, C. Verny, Loiseau, Dominique, D. Milea, Bonneau, Dominique, M. Ferré, P. Reynier, P. Amati-Bonneau, Reynier, Pascal, N. Gueguen, Guillet, Virginie, M.A.Pou de Crescenzo, G. Lenaers   +25 more
core   +2 more sources

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Performing discovery-based proteomics using a novel Opa1-TurboID stable cell line to determine the metabolically dependent Opa1 proteome

, 2023
Cristae are dynamic subcompartments of mitochondria involved in respiratory efficiency, control of cytochrome c release and cellular proliferation. Optic Atrophy 1 (OPA1), a dynamin-related IMM protein, is a central regulator of mammalian cristae shape ...
Jonathan Lambert, Luca Scorrano, Aurora Maracani   +2 more
core  

Protective Effect of Aerobic Training along with Resveratrol on Mitochondrial Dynamics of Cardiac Myocytes in Animal Model of Non-alcoholic Fatty Liver Disease

Journal of Ardabil University of Medical Sciences, 2019
Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction. The aim of the present study was to examine the effect of aerobic training along with resveratrol on cardiac expression of OPA1 and DRP1 in ...
hasan delroz, Ahmad Abdi, Alireza Barari, Parvin Farzanegi   +3 more
doaj