Results 31 to 40 of about 2,978 (195)
Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax
Life Science Alliance, 2020 Mfn2 CMT2A–associated variants located proximal to the hinge connecting its two extended helical bundles have impaired GTP-dependent assembly and mitochondrial fusion activity, which are both improved by cytosolic Bax.
Nyssa B Samanas +2 more
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Mitofusins: Mighty Regulators of Metabolism [PDF]
Cell, 2013 Mitochondria are central regulators of cellular metabolism but how their function in a subset of cells affects whole-body energy balance is less understood. Two studies in this issue of Cell identify how diet-dependent modulation of mitochondrial fusion in specific neuronal circuits impact the metabolic status of an animal.
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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy [PDF]
Human Molecular Genetics, 2010 Mitochondrial dysfunction and perturbed degradation of proteins have been implicated in Parkinson's disease (PD) pathogenesis. Mutations in the Parkin and PINK1 genes are a cause of familial PD. PINK1 is a putative kinase associated with mitochondria, and loss of PINK1 expression leads to mitochondrial dysfunction, which increases with time.
Matthew E, Gegg +5 more
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Control of mitochondrial morphology by a human mitofusin [PDF]
Journal of Cell Science, 2001 ABSTRACT Although changes in mitochondrial size and arrangement accompany both cellular differentiation and human disease, the mechanisms that mediate mitochondrial fusion, fission and morphogenesis in mammalian cells are not understood. We have identified two human genes encoding potential mediators of mitochondrial fusion.
A, Santel, M T, Fuller
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The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes
Communications Biology, 2022 The MFN1 and MFN2 mitofusin proteins localize to the outer mitochondrial membrane, where they may help functionally tether mitochondria to peroxisomes.
Yinbo Huo +4 more
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Mitofusins: ubiquitylation promotes fusion [PDF]
Cell Research, 2014 Mitochondrial genes including Mfn2 are at the center of many diseases, underscoring their potential as a therapeutical target. The Chen group now identified 15-oxospiramilactone as a chemical inhibitor of the mammalian deubiquitylase USP30, acting on Mfn1 and Mfn2.
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Mitochondrial fusion is required for spermatogonial differentiation and meiosis
eLife, 2019 Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Grigor Varuzhanyan +6 more
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Monitoring Mitochondrial Function in Aedes albopictus C6/36 Cell Line during Dengue Virus Infection
Insects, 2021 Aedes aegypti and Aedes albopictus mosquitoes are responsible for dengue virus (DENV) transmission in tropical and subtropical areas worldwide, where an estimated 3 billion people live at risk of DENV exposure.
María E. Santana-Román +7 more
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Pro-diversity mitofusins [PDF]
The Journal of Cell Biology, 2007 Affirmative action groups would be proud of Mfn proteins. These fusion proteins work better with diverse partners, say Detmer and Chan (page [405][1]). The results might help explain why only certain neurons are susceptible in Charcot-Marie-Tooth disease 2A (CMT2A).
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Protein & Cell, 2017 Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson’s disease, dystonia, and epilepsy.
Crystal A. Lee, Lih-Shen Chin, Lian Li
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