Results 31 to 40 of about 3,343 (171)
, 2021 Depolarized/damaged mitochondria aggregate at the perinuclear region prior to mitophagy in cells treated with mitochondrial stressors. However, the cellular mechanism(s) by which damaged mitochondria are transported and remain aggregated at the ...
Guidry, Jessie +8 more
core +1 more source
Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A
eLife, 2020 Charcot–Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2.
Antonietta Franco +10 more
doaj +1 more source
Direct Small Molecule Activation of Mitofusins
, 2018 SummaryMitochondrial fusion is a physiological process that is regulated by mitofusins on the outer mitochondrial membrane. Conformational plasticity between anti- and pro-tethering conformations of mitofusins permits mitochondrial tethering and ...
Gaetano Santulli +9 more
core +1 more source
, 2021 Mitophagy is defective in several neurodegenerative diseases, including Ataxia Telangiectasia (A-T). However, the molecular mechanism underlying defective mitophagy in A-T is unknown.
Reed, Ryan +5 more
core +1 more source
Monitoring Mitochondrial Function in Aedes albopictus C6/36 Cell Line during Dengue Virus Infection
Insects, 2021 Aedes aegypti and Aedes albopictus mosquitoes are responsible for dengue virus (DENV) transmission in tropical and subtropical areas worldwide, where an estimated 3 billion people live at risk of DENV exposure.
María E. Santana-Román +7 more
doaj +1 more source
The INs and OUTs of mitofusins
, 2018 Mitofusins are outer membrane proteins essential for mitochondrial fusion. Their accepted topology posits that both N and C termini face the cytoplasm. In this issue, Mattie et al. (2018. J. Cell Biol.
Giacomello, Marta +3 more
core +1 more source
Structural basis for membrane tethering by a bacterial dynamin-like pair
Nature Communications, 2018 Dynamin-like proteins (DLPs) such as the mitofusins form homotypic and heterotypic oligomers that bridge and fuse opposing membranes. Here, Liu, Noel and Low present the crystal structure of a bacterial DLP heterotypic pair, providing insights into the ...
Jiwei Liu, Jeffrey K. Noel, Harry H. Low
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
The Role of Mitofusins in the Osteoclast Lineage [PDF]
, 2019 Mitochondria exist in a highly dynamic network in many cell types, and mutations in mitochondrial transmembrane GTPase mitofusin2 (MFN2), a key factor that mediates mitochondrial tethering, cause defects in the nervous system.
Ballard, Anna
core +1 more source
Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition
Life Science Alliance, 2019 Mitochondrial fusion requires an alternating salt bridge between CMT2A-associated disease residues that enable GTP hydrolysis; Fzo1 ubiquitylation then licenses post-fusion recycling by Cdc48.
Vincent Anton +9 more
doaj +1 more source