Results 71 to 80 of about 17,663,383 (215)

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Mitofusin-2 acts as biomarker for predicting poor prognosis in hepatitis B virus related hepatocellular carcinoma

Infectious Agents and Cancer, 2018
Objective To investigate the expression of Mitofusin-2 (MFN2) in HCC tissues and its role in the development of HCC. Methods A total of 107 HCC specimens were collected for tissue microarray analysis and immunohistochemistry (IHC) analysis.
Xiumei Wang, Youde Liu, Jing Sun, Wenjing Gong, Ping Sun, Xiangshuo Kong, Miaomiao Yang, Weiwei Zhang   +7 more
doaj   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Mitofusin 2-deficiency suppresses cell proliferation through disturbance of autophagy. [PDF]

PLoS ONE, 2015
Mitofusin2 (Mfn2), a mitochondrial outer membrane protein serving primarily as a mitochondrial fusion protein, has multiple functions in regulating cell biological processes. Defects of Mfn2 were found in diabetes, obesity, and neurodegenerative diseases.
Yanhong Ding, Han Gao, Lifang Zhao, Xian Wang, Ming Zheng   +4 more
doaj   +1 more source

Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons

FASEB BioAdvances, 2020
Dynamic fission and fusion events regulate mitochondrial shape, distribution, and rejuvenation, and proper control of these processes is essential for neuronal homeostasis. Here, we report that Gas7, a known cytoskeleton regulator, controls mitochondrial
Jagannatham Naidu Bhupana, Bo‐Tsang Huang, Gunn‐Guang Liou, Marcus J. Calkins, Sue Lin‐Chao   +4 more
doaj   +1 more source

Role of mitofusin 2 (Mfn2) in controlling cellular proliferation

The FASEB Journal, 2013
It has been reported that Mitofusin2 (Mfn2) inhibits cell proliferation when overexpressed. We wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural features of Mfn2 that influence its mitochondrial localization and control of cell proliferation. Mfn2‐knockdown clones of a B‐cell lymphoma cell
Kuang-Hueih, Chen, Asish, Dasgupta, Jinhui, Ding, Fred E, Indig, Paritosh, Ghosh, Dan L, Longo   +5 more
openaire   +3 more sources

Role of Mitofusins and Mitophagy in Life or Death Decisions

Frontiers in Cell and Developmental Biology, 2020
Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy ...
Mariana Joaquim, Mafalda Escobar-Henriques   +1 more
doaj   +1 more source

Mitophagy: Mitofusin Recruits a Mitochondrial Killer

, 2013
SummaryParkin is a cytosolic ubiquitin ligase that translocates to damaged mitochondria and promotes their degradation. Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin ...
Pallanck, Leo
core   +1 more source

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes [PDF]

Journal of Biological Chemistry, 2012
In the heart, autophagy has been implicated in cardioprotection and ischemia-reperfusion tolerance, and the dysregulation of autophagy is associated with the development of heart failure. Mitochondrial dynamic proteins are profoundly involved in autophagic processes, especially the initiation and formation of autophagosomes, but it is not clear whether
Ting, Zhao, Xiaohu, Huang, Liang, Han, Xianhua, Wang, Hongqiang, Cheng, Yungang, Zhao, Quan, Chen, Ju, Chen, Heping, Cheng, Ruiping, Xiao, Ming, Zheng   +10 more
openaire   +2 more sources

Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy

Clinical Genetics, EarlyView.
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk, Aleš Maver, Martina Jarc Vidmar, Nuša Trošt, Tanja Višnjar, Ana Fakin, Lea Kovač, Maja Šuštar Habjan, Lucija Malinar, Sanja Petrović Pajić, Urška Dragin Jerman, Rok Romih, Marko Hawlina, Borut Peterlin   +13 more
wiley   +1 more source