Results 91 to 100 of about 15,895 (241)

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Role of mitofusin 2 (Mfn2) in controlling cellular proliferation

The FASEB Journal, 2013
It has been reported that Mitofusin2 (Mfn2) inhibits cell proliferation when overexpressed. We wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural features of Mfn2 that influence its mitochondrial localization and control of cell proliferation. Mfn2‐knockdown clones of a B‐cell lymphoma cell
Kuang-Hueih, Chen, Asish, Dasgupta, Jinhui, Ding, Fred E, Indig, Paritosh, Ghosh, Dan L, Longo   +5 more
openaire   +3 more sources

Nicotine Affects Multiple Biological Processes in EpiDerm^TM Organotypic Tissues and Keratinocyte Monolayers

Atmosphere, 2022
Dermal exposure to nicotine is common due to the widespread use of tobacco products. Here, we assessed the effects of nicotine at concentrations found in thirdhand smoke (THS) contaminated environments and electronic cigarette (EC) spills or leaks on a ...
Giovanna L. Pozuelos, Matine Rubin, Samantha Vargas, Erik Ramirez, Dhiresh Bandaru, Jihui Sha, James Wohlschlegel, Prue Talbot   +7 more
doaj   +1 more source

The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells [PDF]

, 2014
AIMS: Mitofusin-2 (Mfn2) expression is dysregulated in vascular proliferative disorders and its overexpression attenuates the proliferation of vascular smooth muscle cells (VSMCs) and neointimal lesion development after balloon angioplasty.
Andrés García, Vicente, Fernández Pascual, Sergio, González Navarro, Herminia, Naón Elbirt, Déborah P., Palacín Prieto, Manuel, Portugal, José, 1954-, Sancho Medina, Ana, Sorianello, Eleonora, Vila Caballer, Marian, Zaragoza, Francesc X. (Francesc Xavier), Zorzano Olarte, Antonio   +10 more
core   +2 more sources

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes [PDF]

Journal of Biological Chemistry, 2012
In the heart, autophagy has been implicated in cardioprotection and ischemia-reperfusion tolerance, and the dysregulation of autophagy is associated with the development of heart failure. Mitochondrial dynamic proteins are profoundly involved in autophagic processes, especially the initiation and formation of autophagosomes, but it is not clear whether
Ting, Zhao, Xiaohu, Huang, Liang, Han, Xianhua, Wang, Hongqiang, Cheng, Yungang, Zhao, Quan, Chen, Ju, Chen, Heping, Cheng, Ruiping, Xiao, Ming, Zheng   +10 more
openaire   +2 more sources

Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice [PDF]

, 2015
Copyright © 2015 Lina M. Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited ...
Barreto, Marlen, Elorza, Alvaro A, Jensen, Erik, Quintanilla, Rodrigo A, Ruiz Hincapie, Paula, Ruiz, Lina M, Salazar, Celia, Tiznado, William   +7 more
core   +9 more sources

Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling

Nature Communications, 2021
Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis and ...
Young-Mee Kim, Sarah Krantz, Ankit Jambusaria, Peter T. Toth, Hyung-Geun Moon, Isuru Gunarathna, Gye Young Park, Jalees Rehman   +7 more
doaj   +1 more source

Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. [PDF]

, 2014
Mitochondrial fusion and fission is a dynamic process critical for the maintenance of mitochondrial function and cell viability. During excitotoxicity neuronal mitochondria are fragmented, but the mechanism underlying this process is poorly understood ...
Abramoff MD, Alejandro Martorell‐Riera, Antonio Zorzano, Francesc X Soriano, Jeús Pérez‐Clausell, Jordi Olloquequi, Juan P Muñoz, Julien Puyal, Li M, Manuel Palacín, Manuel Reina, Marc Segarra‐Mondejar, Soriano FX, Stout AK, Vanessa Ginet   +14 more
core   +2 more sources

Proteomics of Cytochrome c Oxidase-Negative versus -Positive Muscle Fiber Sections in Mitochondrial Myopathy [PDF]

, 2019
The mosaic distribution of cytochrome c oxidase(+) (COX+) and COX - muscle fibers in mitochondrial disorders allows the sampling of fibers with compensated and decompensated mitochondrial function from the same individual.
Doll, S., Geyer, P., Klopstock, T., Mann, M., Murgia, M., Tan, J.   +5 more
core   +3 more sources