Role of mitofusin 2 and mitochondrial dynamics in osteoclast differentiation and function
Os osteoclastos são macrófagos tecido-específicos com a função de reabsorção óssea. Por serem células gigantes e multinucleadas, os osteoclastos necessitam, desde a sua formação, passando pela adesão e movimentação na superfície óssea e finalmente pela ...
Venturini, Lucas Gabriel Rodrigues
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Overexpression of mitofusin 2 in the diabetic heart; pathological or cardioprotective remodelling?
, 2015 Background: Mitochondrial dysfunction is an established hallmark of diabetic cardiomyopathy (DCM). Mitofusin 2 (Mfn2) is widely believed to function as a molecular tether, binding mitochondria to the sarcoplasmic reticulum (SR) to form specialised Ca2 ...
Kitmitto, Ashraf +6 more
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Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis
, 2007 An inexorable loss of terminally differentiated heart muscle cells is a crucial causal factor for heart failure. Here, we have provided several lines of evidence to demonstrate that mitofusin-2 (Mfn-2; also called hyperplasia suppressor gene), a member ...
Shen, Tao +17 more
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Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A [PDF]
, 2017 Charcot-Marie-Tooth disease type 2A is an autosomal dominant axonal form of peripheral neuropathy caused by mutations in the mitofusin 2 gene. Mitofusin 2 encodes a mitochondrial outer membrane protein that participates in mitochondrial fusion in ...
Courvoisier, Delphine S. +6 more
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, 2012 The induction of “in vitro” capacitation (IVC) and subsequent, progesterone-induced “in vitro” acrosome reaction (IVAR) was concomitant with an increase in actin polymerization, also showing an increase in actin presence at the apical area of the ...
J. M. Fernández Novell +5 more
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Mitofusin-2 Expression Is Implicated in Cervical Cancer Pathogenesis
, 2018 BACKGROUND/AIM: It remains unclear whether mitofusin-2 (MFN2) functions as a tumour suppressor or oncogene in cancer progression. In this study we, therefore, aimed to investigate the effect of MFN2 on the pathogenesis of cervical cancer.
현영민, 장향란, 안성용
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The Role of Mammalian Mitofusin-2 (Mfn-2) in Lipid Metabolism [PDF]
, 2017 The architecture of mitochondria is closely associated with numerous functions for cell signaling, growth and senescence. The overall phenomenon of mitochondrial dynamics, which include fusion and fission events, characterizes the fundamental mechanism ...
Ambilwade, Prashant of 1984-
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Prognostic impact of mitofusin 2 expression in colon cancer. [PDF]
Transl Cancer Res, 2022 Cheng X, Li Y, Liu F.
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Zebrafish mitofusin-2 knockdown: a new model for CMT2A neuropathy?
, 2009 Mitofusin 2 (MFN2) is a large dynamin-like GTPase protein, located in the outer membrane of mitochondria and at the surface of the endoplasmic reticulum.
VETTORI, ANDREA +7 more
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Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells. [PDF]
Int J Mol Sci, 2023 Yegambaram M +10 more
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