Results 101 to 110 of about 15,895 (241)

Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2

Cell Reports, 2016
Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and mitochondria is crucial for regulation of various physiological and pathophysiological processes. Here,
Riccardo Filadi, Elisa Greotti, Gabriele Turacchio, Alberto Luini, Tullio Pozzan, Paola Pizzo   +5 more
doaj   +1 more source

Staging chronic pancreatitis with exocrine function tests: Are we better? [PDF]

, 2017
Chronic pancreatitis (CP) is an inflammatory disease of the pancreas evolving in progressive fibrotic disruption of the gland with exocrine and endocrine pancreatic insufficiency.
MOLETTA, LUCIA, SPERTI, COSIMO
core   +1 more source

Mutational analysis of action of mitochondrial fusion factor mitofusin-2 [PDF]

Journal of Cell Science, 2005
Mitofusin-2 (Mfn2) is an essential component of mitochondrial fusion machinery, but its molecular mechanism of action is not clear. We found that a Mfn2 deletion mutant lacking two transmembrane spans (MfnΔTM) acts as a dominant-negative mutant and blocks mitochondrial fusion.
Honda, S., Aihara, T., Hontani, M., Okubo, K., Hirose, S.   +4 more
openaire   +2 more sources

Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A

eLife, 2020
Charcot–Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2.
Antonietta Franco, Xiawei Dang, Emily K Walton, Joshua N Ho, Barbara Zablocka, Cindy Ly, Timothy M Miller, Robert H Baloh, Michael E Shy, Andrew S Yoo, Gerald W Dorn II   +10 more
doaj   +1 more source

Acute Endurance Exercise Induces Nuclear p53 Abundance in Human Skeletal Muscle [PDF]

, 2016
Purpose: The tumor suppressor protein p53 may have regulatory roles in exercise response-adaptation processes such as mitochondrial biogenesis and autophagy, although its cellular location largely governs its biological role.
Bartlett, Bartlett, Bartlett, Burd, Camera, Camera, Drake, Egan, Feng, Fry, Gurtler, Hawley, Hawley, Hawley, Jamart, Jamart, Jamart, Kim, Kruiswijk, Lira, Little, Little, Louis, Maiuri, Matoba, Mizushima, Mizushima, Narendra, Nedergaard, Park, Perez-Schindler, Plomp, Qiao, Ruas, Safdar, Saleem, Saleem, Schwalm, Sin, Singh, Smiles, Tanida, Twig, Vives-Bauza, Yan   +44 more
core   +3 more sources

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Mitofusin 2 keeps the respiratory chain on Q [PDF]

Journal of Cell Biology, 2015
![Figure][1] Many mitochondria (green) show reduced membrane potential (indicated by the potentiometric reporter TMRM, red) in fibroblasts lacking MFN2. [Mourier et al.][2] reveal that the mitochondrial fusion protein Mitofusin 2 (MFN2) is required to maintain production of the ...
openaire   +1 more source

Reduced alfa-MSH underlies hypothalamic ER-stress-induced hepatic gluconeogenesis [PDF]

, 2016
Alterations in ER homeostasis have been implicated in the pathophysiology of obesity and type-2 diabetes (T2D). Acute ER stress induction in the hypothalamus produces glucose metabolism perturbations.
Altirriba Gutiérrez, Jordi, Bortolozzi Biasoni, Analía, Claret i Carles, Marc, Drougard, Anne, Esteban, Yaiza, Ferrés Coy, Albert, Garcia, Ainhoa, García-Roves, Pablo M. (Pablo Miguel), Gomis, Ramon, 1946-, Gómez Valadés, Alicia G., Jones, John G., Manadas, Bruno, Ramírez, Sara, Schneeberger, Marc, Sebastián Muñoz, David, Zorzano Olarte, Antonio   +15 more
core   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

Redox Biology, 2017
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is
Susana Rovira-Llopis, Celia Bañuls, Noelia Diaz-Morales, Antonio Hernandez-Mijares, Milagros Rocha, Victor M. Victor   +5 more
doaj   +1 more source