Results 11 to 20 of about 15,895 (241)
Role of mitofusin 2 in the renal stress response. [PDF]
PLoS ONE, 2012 The role of mitofusin 2 (MFN2), a key regulator of mitochondrial morphology and function in the renal stress response is unknown. To assess its role, the MFN2 floxed gene was conditionally deleted in the kidney of mice (MFN2 cKO) by Pax2 promoter driven ...
Jonathan M Gall +8 more
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Mitofusin 2 Dysfunction and Disease in Mice and Men [PDF]
Frontiers in Physiology, 2020 A causal relationship between Mitofusin (MFN) 2 gene mutations and the hereditary axonal neuropathy Charcot-Marie-Tooth disease type 2A (CMT2A) was described over 15 years ago. During the intervening period much has been learned about MFN2 functioning in
Gerald W. Dorn
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Mitofusin-2: A New Mediator of Pathological Cell Proliferation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cell proliferation is an important cellular process for physiological tissue homeostasis and remodeling. The mechanisms of cell proliferation in response to pathological stresses are not fully understood.
Yanguo Xin +4 more
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Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight [PDF]
Cell Reports, 2019 Summary: We found that exposure of adult animals to calorie-dense foods rapidly abolished expression of mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and mitochondrion-endoplasmic reticulum interactions, in white and brown fat.
Giacomo Mancini +5 more
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Prognostic impact of mitofusin 2 expression in colon cancer. [PDF]
Transl Cancer Res, 2022 Mitofusin 2 (MFN2) is involved in several biological processes, including cancer. MFN2 is downregulated in some types of cancer and inhibits cancer cell proliferation, migration, and invasion. However, the relationship between MFN2 and colon cancer remains unknown.In this study, MFN2 expression was investigated using The Cancer Genome Atlas (TCGA) and ...
Cheng X, Li Y, Liu F.
europepmc +3 more sources
Back to The Fusion: Mitofusin-2 in Alzheimer’s Disease [PDF]
Journal of Clinical Medicine, 2020 Mitochondria are dynamic organelles that undergo constant fission and fusion. Mitochondria dysfunction underlies several human disorders, including Alzheimer’s disease (AD). Preservation of mitochondrial dynamics is fundamental for regulating the organelle’s functions.
Sita, Giulia +3 more
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Unveiling a Rare Phenotypic Presentation of Mitofusin 2 Mutation as Cerebellar Ataxia [PDF]
Annals of Indian Academy of NeurologyPriya Robert +3 more
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Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study. [PDF]
PLoS ONE, 2012 Besides its role in controlling the morphology of mitochondria, mitofusin-2 has been proposed to tether mitochondria to the endoplasmic reticulum (ER), based largely on light microscopic analysis. In this study we have examined by electron microscopy the
Pierre Cosson +3 more
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Mitofusin 2: from functions to disease [PDF]
Cell Death & Disease, 2018 AbstractMitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously remodeled through the balance between fusion and fission events. Moreover, it dynamically contacts other organelles, particularly the endoplasmic reticulum, with which it enterprises an ...
Filadi, Riccardo +2 more
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Frontiers in Physiology, 2021 Cardiac fibrosis is evident even in the situation without a significant cardiomyocyte loss in diabetic cardiomyopathy and a high glucose (HG) level independently activates the cardiac fibroblasts (CFs) and promotes cell proliferation.
Ling-Yu Zhang +13 more
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