Results 11 to 20 of about 3,353 (142)

Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer

Pharmacogenomics and Personalized Medicine, 2021
Xiaohua Liang,1 Shengqiang Dang2 1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China; 2Department of Oncology, Chang’an Hospital of Xi’an, Xi&
Liang X, Dang S
doaj   +1 more source

MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A [PDF]

iScience
Summary: Mitofusin-2 (MFN2), a large GTPase residing in the mitochondrial outer membrane and mutated in Charcot-Marie-Tooth type 2 disease (CMT2A), is a regulator of mitochondrial fusion and tethering with the ER.
Atul Kumar, Delfina Larrea, Maria Elena Pero, Paola Infante, Marilisa Conenna, Grace J. Shin, Vincent Van Elias, Wesley B. Grueber, Lucia Di Marcotullio, Estela Area-Gomez, Francesca Bartolini   +10 more
doaj   +2 more sources

Role of Mfn2 in Macrophage Inflammatory Responses [PDF]

, 2017
[eng] Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several signaling pathways ...
Tur Torres, Juan
core   +8 more sources

Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin‐induced myocardial injury [PDF]

, 2023
Background Doxorubicin is a widely used cytotoxic chemotherapy agent for treating different malignancies. However, its use is associated with dose-dependent cardiotoxicity, causing irreversible myocardial damage and significantly reducing the patient's ...
Wang, Yueying, Zhou, Zandong, Tse, Gary, Xie, Bingxin, Zhang, Yue, King, Emma, Zhang, Q., Liu, Daiqi, Liu, T., Zhang, Y.   +9 more
core   +1 more source

Cognitive decline in Mfn2 KO mice: role of Mfn2 in neuronal plasticity [PDF]

[eng] Mitofusin 2 (Mfn2) is a protein initially characterized as a mitochondrial fusion protein with a bioenergetic function, like Mitofusin 1. Beyond its role in bioenergetics, Mfn2 also acts as an ER-mitochondria tether, which plays a critical role in ...
Riqué Pujol, Guillem
core   +7 more sources

Characterization of a novel variant in the HR1 domain of MFN2 in a patient with ataxia, optic atrophy and sensorineural hearing loss [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research, 2022
Background: Pathogenic variants in MFN2 cause Charcot-Marie-Tooth disease (CMT) type 2A (CMT2A) and are the leading cause of the axonal subtypes of CMT.
Davide Martino, Kristina Martens, Matthew Joel, Rasha Sabouny, Mashiat Zaman, Timothy E. Shutt, Gerald Pfeffer, A.P. Jason de Koning, Govinda Sharma   +8 more
doaj   +1 more source

Isorhapontigenin attenuates cardiac microvascular injury in diabetes mellitus via the inhibition of mitochondrial-derived ferroptosis through PRDX2-MFN2-ACSL4 pathways.

, 2022
Ferroptosis is a newly identified form of regulated cell death that is driven by iron overload and uncontrolled lipid peroxidation, but the role of ferroptosis in cardiac microvascular dysfunction remains unclear.
Jun Zhang (48506), Su Li (294188), Yuqiong Chen (7380617), Ming Yin (116282), Yafei Li (184478), Kangyun Sun (7293230), Zhangwei Chen (4768857), Juying Qian (520444), Chao Chen (195669), Xiangqing Kong (471440)   +9 more
core   +1 more source

Two rare human mitofusin 2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology in Drosophila. [PDF]

PLoS ONE, 2012
Mitochondrial fusion is essential to organelle homeostasis and organ health. Inexplicably, loss of function mutations of mitofusin 2 (Mfn2) specifically affect neurological tissue, causing Charcot Marie Tooth syndrome (CMT) and atypical optic atrophy. As
William H Eschenbacher, Moshi Song, Yun Chen, Poonam Bhandari, Peter Zhao, Casey C Jowdy, John T Engelhard, Gerald W Dorn   +7 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

The Charcot–Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress

Cells, 2019
Charcot−Marie tooth disease is a hereditary polyneuropathy caused by mutations in Mitofusin-2 (MFN2), a GTPase in the outer mitochondrial membrane involved in the regulation of mitochondrial fusion and bioenergetics.
Christina Wolf, Rahel Zimmermann, Osamah Thaher, Diones Bueno, Verena Wüllner, Michael K.E. Schäfer, Philipp Albrecht, Axel Methner   +7 more
doaj   +1 more source