Results 11 to 20 of about 14,571 (197)
Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis. [PDF]
PLoS ONE, 2015 Growth factors, energy sources, and mitochondrial function strongly affect embryo growth and development in vitro. The biological role and prospective significance of the mitofusin gene Mfn2 in the development of preimplantation embryos remain poorly ...
Na Zhao +3 more
doaj +4 more sources
Mfn2 Overexpression Attenuates MPTP Neurotoxicity In Vivo [PDF]
International Journal of Molecular Sciences, 2021 Mitochondrial dysfunction represents a critical event in the pathogenesis of Parkinson’s disease (PD). Increasing evidence demonstrates that disturbed mitochondrial dynamics and quality control play an important role in mitochondrial dysfunction in PD. Our previous study demonstrated that MPP+ induces mitochondrial fragmentation in vitro. In this study,
Fanpeng Zhao +3 more
openaire +2 more sources
MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice [PDF]
International Journal of Molecular Sciences, 2021 MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined.
Junru Miao +6 more
openaire +2 more sources
Cavitating leukodystrophy as a manifestation of cerebral involvement in MFN2 neuropathy [PDF]
Neurology, 2020 A 16-year-old girl presented with progressive bilateral lower limb weakness for 3 years. Examination revealed tongue fasciculations, muscle wasting, and extensor plantar responses. Nerve conduction studies revealed motor-sensory axonal polyneuropathy. MRI brain showed multifocal cavitating white matter disease with diffusion restriction (figures 1 and ...
Ranjith Kumar, Manokaran +2 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Mitofusin-2 modulates the epithelial to mesenchymal transition in thyroid cancer progression
Scientific Reports, 2021 Here, we investigated the potential roles of Mitofusin-2 (MFN2) in thyroid cancer progression. MFN2 regulates mitochondrial fusion/division in cells and plays an important role in various aspects of cell metabolism.
Mi-Hyeon You +9 more
doaj +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
F1000Research, 2022 Background: Pathogenic variants in MFN2 cause Charcot-Marie-Tooth disease (CMT) type 2A (CMT2A) and are the leading cause of the axonal subtypes of CMT.
Davide Martino +8 more
doaj +1 more source