Results 31 to 40 of about 3,353 (142)

Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages

Cells, 2019
Apoptosis is an important host defense mechanism against mycobacterial infection. However, the molecular mechanisms regulating apoptosis during mycobacterial infection are not well known.
Junghwan Lee, Ji-Ae Choi, Soo-Na Cho, Sang-Hun Son, Chang-Hwa Song   +4 more
doaj   +1 more source

Impaired mitochondrial dynamics and removal of the damaged mitochondria in diabetic retinopathy

Frontiers in Endocrinology, 2023
IntroductionMitochondrial dynamic plays a major role in their quality control, and the damaged mitochondrial components are removed by autophagy. In diabetic retinopathy, mitochondrial fusion enzyme, mitofusin 2 (Mfn2), is downregulated and mitochondrial
Kumari Alka, Jay Kumar, Renu A. Kowluru
doaj   +1 more source

Mitofusin-2 acts as biomarker for predicting poor prognosis in hepatitis B virus related hepatocellular carcinoma

Infectious Agents and Cancer, 2018
Objective To investigate the expression of Mitofusin-2 (MFN2) in HCC tissues and its role in the development of HCC. Methods A total of 107 HCC specimens were collected for tissue microarray analysis and immunohistochemistry (IHC) analysis.
Xiumei Wang, Youde Liu, Jing Sun, Wenjing Gong, Ping Sun, Xiangshuo Kong, Miaomiao Yang, Weiwei Zhang   +7 more
doaj   +1 more source

Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events

Frontiers in Cell and Developmental Biology, 2022
Mitochondrial repair is essential to metabolic homeostasis. Outer mitochondrial membrane mitofusin (MFN) proteins orchestrate mitochondrial fusion that opposes mitochondrial degeneration caused by senescence.
Jiajia Li, Xiawei Dang, Antonietta Franco, Gerald W Dorn   +3 more
doaj   +1 more source

Circ-MFN2 Positively Regulates the Proliferation, Metastasis, and Radioresistance of Colorectal Cancer by Regulating the miR-574-3p/IGF1R Signaling Axis

Frontiers in Genetics, 2021
Numerous studies have shown that the expression of circular RNA (circRNA) is closely related to the malignant progression of cancer. However, the role of circ-MFN2 in colorectal cancer (CRC) is unclear. Our study aims to explore the role and mechanism of
Defeng Liu, Shihao Peng, Yangyang Li, Tao Guo   +3 more
doaj   +1 more source

Overall MFN2 model structure.

, 2017
Colors demonstrate domain division: GTPase (blue), HR-1 (green), HR-2 (yellow), and paddle region (orange). A. MFN2 monomer structure with visible GTP showed as Van der Waals spheres. B.
Łukasz Charzewski (3632887), Andrzej Kochański (3632890), Anna Boratyńska-Jasińska (778494), Barbara Zabłocka (778497), Małgorzata Beręsewicz (778495), Maria Kawalec (778493), Krystiana A. Krzyśko (3632884), Dagmara Kabzińska (3632893)   +7 more
core   +1 more source

Mitofusin 2-deficiency suppresses cell proliferation through disturbance of autophagy. [PDF]

PLoS ONE, 2015
Mitofusin2 (Mfn2), a mitochondrial outer membrane protein serving primarily as a mitochondrial fusion protein, has multiple functions in regulating cell biological processes. Defects of Mfn2 were found in diabetes, obesity, and neurodegenerative diseases.
Yanhong Ding, Han Gao, Lifang Zhao, Xian Wang, Ming Zheng   +4 more
doaj   +1 more source

Mfn2 knockdown inhibits cell proliferation.

, 2015
(A) Western blotting showing Mfn2 and Mfn1 protein levels in HeLa cells infected with adenovirus containing scrambled RNA or two sets of Mfn2 shRNAs. β-actin was used as protein loading control.
Lifang Zhao (615582), Ming Zheng (295946), Yanhong Ding (704111), Han Gao (486886), Xian Wang (15374)   +4 more
core   +1 more source

The Effect of 4 Weeks of Aerobic Training on Spatial Learning, Memory Performance and Mitochondrial Dynamics in the Hippocampal Tissue of Old Rats

Journal of Ardabil University of Medical Sciences, 2020
Background & objectives: Mitochondrial dysfunction is one of the main risk factors for neurological diseases which are associated with aging. On the other hand, aerobic exercise has beneficial effects on the brain health and cognitive function, and also ...
Ahmad Fazeli Sani, Hasan Matin homaee, Abdolali Banaeifar   +2 more
doaj  

Mitofusin2, as a Protective Target in the Liver, Controls the Balance of Apoptosis and Autophagy in Acute-on-Chronic Liver Failure

Frontiers in Pharmacology, 2019
Aim: Acute-on-chronic liver failure (ACLF) is closely related to mitochondrial dysfunction. Previous studies showed the vital role of mitofusin2 (Mfn2) in the regulation of mitochondrial function. However, the effect of Mfn2 on ACLF remains unknown.
Ran Xue, Jing Yang, Lin Jia, Xuemin Zhu, Jing Wu, Yueke Zhu, Qinghua Meng   +6 more
doaj   +1 more source