Results 31 to 40 of about 21,491 (246)

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources

Role of mitofusin 2 in the renal stress response. [PDF]

PLoS ONE, 2012
The role of mitofusin 2 (MFN2), a key regulator of mitochondrial morphology and function in the renal stress response is unknown. To assess its role, the MFN2 floxed gene was conditionally deleted in the kidney of mice (MFN2 cKO) by Pax2 promoter driven ...
Jonathan M Gall, Zhiyong Wang, Marc Liesa, Anthony Molina, Andrea Havasi, John H Schwartz, Orian Shirihai, Steven C Borkan, Ramon G B Bonegio   +8 more
doaj   +1 more source

Emerging functions of mammalian mitochondrial fusion and fission [PDF]

, 2005
Mitochondria provide a myriad of services to the cell, including energy production, calcium buffering and regulation of apoptosis. How these diverse functions are coordinated among the hundreds of mitochondria in a given cell is largely unknown, but is ...
Chan, David C., Chen, Hsiuchen
core   +1 more source

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]

, 2015
Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Anderson, G, Cale, CM, Chalasani, A, Chan, E, Duchen, MR, Gilmour, KC, Hambleton, S, Jacques, S, Osellame, LD, Plagnol, V, Qasim, W, Rahman, S, Shahni, R, Taanman, JW, Wadatilake, Y   +14 more
core   +1 more source

Reply: MFN2 mutations cause compensatory mitochondrial DNA proliferation [PDF]

Brain, 2012
ARTICLE Sir, We recently reported in Brain a large Tunisian family with optic atrophy ‘plus’ phenotype including axonal neuropathy, deafness, cerebellar ataxia and mitochondrial myopathy with ragged-red and cytochrome c oxidase (COX)-negative fibres (Rouzier et al ., 2012). This neurological disorder is linked to a novel heterozygous missense mutation
C. Rouzier, S. Bannwarth, A. Chaussenot, A. Chevrollier, A. Verschueren, N. Bonello-Palot, K. Fragaki, A. Cano, J. Pouget, J.-F. Pellissier, V. Procaccio, B. Chabrol, V. Paquis-Flucklinger   +12 more
openaire   +1 more source

The essential role of mitochondrial dynamics in antiviral immunity. [PDF]

, 2018
Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun, Kim, Seong-Jun, Siddiqui, Aleem, Syed, Gulam H   +3 more
core   +2 more sources

MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons* [PDF]

Journal of Biological Chemistry, 2015
Mitochondrial dysfunction plays a central role in glutamate-evoked neuronal excitotoxicity, and mitochondrial fission/fusion dynamics are essential for mitochondrial morphology and function. Here, we establish a novel mechanistic linker among glutamate excitotoxicity, mitochondrial dynamics, and mitochondrial dysfunction in spinal cord motor neurons ...
Wenzhang, Wang, Fan, Zhang, Li, Li, Fangqiang, Tang, Sandra L, Siedlak, Hisashi, Fujioka, Yingchao, Liu, Bo, Su, Yan, Pi, Xinglong, Wang   +9 more
openaire   +2 more sources

Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

Frontiers in Physiology, 2019
BackgroundMitochondrial dynamics play a critical role in mitochondrial function. The mitofusin 2 (MFN2) gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion to maintain and operate the mitochondrial network.
Wenjun Xiong, Wenjun Xiong, Zhuang Ma, Zhuang Ma, Dongqi An, Dongqi An, Zuheng Liu, Zuheng Liu, Wanqiang Cai, Wanqiang Cai, Yujia Bai, Yujia Bai, Qiong Zhan, Qiong Zhan, Wenyan Lai, Wenyan Lai, Qingchun Zeng, Qingchun Zeng, Hao Ren, Hao Ren, Dingli Xu, Dingli Xu   +21 more
doaj   +1 more source

Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation [PDF]

, 2016
Mitochondria-associated membranes (MAMs) are subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. This membrane scrambling between ER and mitochondria appears to play a critical role in the earliest steps of autophagy.
Faggioni, Alberto, Gambardella, Lucrezia, Garofalo, Tina, Malorni, Walter, Manganelli, Valeria, Marconi, Matteo, Matarrese, Paola, Misasi, Roberta, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +2 more sources

Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation

Cells, 2022
Inter-organellar communication is emerging as one of the most crucial regulators of cellular physiology. One of the key regulators of inter-organellar communication is Mitofusin-2 (MFN2).
Jyoti Tanwar, Suman Saurav, Reelina Basu, Jaya Bharti Singh, Anshu Priya, Maitreyee Dutta, Uma Santhanam, Manoj Joshi, Stephen Madison, Archana Singh, Nirmala Nair, Rajesh S. Gokhale, Rajender K. Motiani   +12 more
doaj   +1 more source