Results 41 to 50 of about 3,353 (142)

Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway

Frontiers in Cell and Developmental Biology, 2021
The endoplasmic reticulum (ER) stress and mitochondrial dysfunction in high glucose (HG)-induced podocyte injury have been demonstrated to the progression of diabetic kidney disease (DKD). However, the pathological mechanisms remain equivocal. Mitofusin2
Yun Cao, Yun Cao, Zhaowei Chen, Zhaowei Chen, Jijia Hu, Jijia Hu, Jun Feng, Jun Feng, Zijing Zhu, Zijing Zhu, Yanqin Fan, Yanqin Fan, Qiaoxuan Lin, Qiaoxuan Lin, Guohua Ding, Guohua Ding   +15 more
doaj   +1 more source

A zebrafish MFN2 mutant.

, 2013
(A) CLUSTAL alignment of zebrafish (Danio rerio: DR) and human (Homo sapiens: HS) Mfn2 protein sequences (Ensembl). The solid and dashed lines indicate the GTPase and transmembrane domains respectively.
Kurt J. De Vos (427049), Ellen J. Bennett (345864), Andrew J. Grierson (148102), Tennore M. Ramesh (427048), Anna L. Chapman (427047)   +4 more
core   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Human Mfn2 M393I and R400Q mutations are dysfunctional for inducing mitochondrial fusion in Mfn2-deficient MEFs.

, 2016
(A) Confocal analyses (600×) of MitoTracker green stained wild-type (left panels, Control) and Mfn2-null (right panels) MEFs. Nuclei are stained blue with DAPI. Right panels of each pair are enlarged sections of the left panel.
Casey C. Jowdy (137512), William H. Eschenbacher (137498), Peter Zhao (137509), John T. Engelhard (137515), Yun Chen (377354), Gerald W. Dorn II (137519), Poonam Bhandari (137506), Moshi Song (137502)   +7 more
core   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Generation and phenotype of MFN2 cKO mice.

, 2013
(A) Two LoxP sites flank exon 6 in the region coding for the canonical G-1 GTPase motif are shown. Cre recombinase excises exon 6 that causes a frame shift which precludes functional protein production.
John H. Schwartz (334076), Steven C. Borkan (334077), Orian Shirihai (112669), Andrea Havasi (334074), Jonathan M. Gall (334070), Zhiyong Wang (313131), Ramon G. B. Bonegio (334078), Anthony Molina (334072), Marc Liesa (35879)   +8 more
core   +1 more source

Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cervical carcinoma continues to be one of the most dangerous cancer types, and more effective therapies are urgently needed for cervical carcinoma treatment.
Weiqiong Wang, Xiaowen Liu, Xiaomei Guo, Huanhuan Quan   +3 more
doaj   +1 more source

RETRACTED: Mfn2 Overexpression Attenuates Cardio-Cerebrovascular Ischemia–Reperfusion Injury Through Mitochondrial Fusion and Activation of the AMPK/Sirt3 Signaling

Frontiers in Cell and Developmental Biology, 2020
Mitochondria are potential targets for the treatment of cardio-cerebrovascular ischemia–reperfusion (I/R) injury. However, the role of the mitofusin 2 (Mfn2) protein in regulating mitochondrial fusion and cell survival has not been investigated.
Min Liu, Xiaoyang Li, Dezhi Huang
doaj   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Mfn2 knockdown impairs autophagic degradation.

, 2015
(A) Increased LC3-II level in Mfn2 knockdown HeLa cells by Western blot. n = 4 independent experiments for each group. (B) LC3-II:GAPDH ratios in HeLa cells infected with scrambled RNA, Mfn2 shRNA, or Mfn2 shRNA with Mfn2 cDNA.
Lifang Zhao (615582), Ming Zheng (295946), Yanhong Ding (704111), Han Gao (486886), Xian Wang (15374)   +4 more
core   +1 more source