Results 51 to 60 of about 14,571 (197)

Mfn2 is critical for brown adipose tissue thermogenic function

The EMBO Journal, 2017
Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics. Defective mitofusin 2 (Mfn2) expression and enhanced mitochondrial fission in skeletal muscle are hallmarks of insulin-resistant states.
Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valera‐Alberni, Roy Combe, Antonio Zorzano, Carles Cantó   +7 more
openaire   +3 more sources

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cervical carcinoma continues to be one of the most dangerous cancer types, and more effective therapies are urgently needed for cervical carcinoma treatment.
Weiqiong Wang, Xiaowen Liu, Xiaomei Guo, Huanhuan Quan   +3 more
doaj   +1 more source

MFN2 retrotranslocation boosts mitophagy by uncoupling mitochondria from the ER [PDF]

Autophagy, 2018
Mitochondrial damage triggers mitochondrial quality control pathways, which act to ensure the health of the mitochondrial network. The turnover of damaged mitochondria by mitophagy is initiated by the Parkinson disease-linked genes PRKN and PINK1, and we recently investigated the role that interorganellar contact sites between the endoplasmic reticulum
Gian-Luca McLelland, Edward A. Fon
openaire   +2 more sources

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Diosgenin induces apoptosis in hepatocellular carcinoma cells via the MFN2-mediated mitochondrial autophagy pathway

徐州医科大学学报
Objective To investigate whether diosgenin (Dio) induces apoptosis in hepatocellular carcinoma (HCC) cells by regulating the mitochondrial fusion protein 2 (MFN2)-mediated mitochondrial autophagy pathway.
HAN Shuai, HU Haoyang, ZHENG Jiapeng, CHEN Jianli   +3 more
doaj   +1 more source

MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4

FEBS Open Bio, 2023
Mitofusin‐2 (MFN2) is a transmembrane GTPase that regulates mitochondrial fusion and thereby modulates mitochondrial function. However, the role of MFN2 in lung adenocarcinoma remains controversial.
Jingjing Zhang, Lifang Pan, Qiang Zhang, Yanyan Zhao, Wenwen Wang, Nengming Lin, Shirong Zhang, Qiong Wu   +7 more
doaj   +1 more source

Role of mitofusin 2 (Mfn2) in controlling cellular proliferation

The FASEB Journal, 2013
It has been reported that Mitofusin2 (Mfn2) inhibits cell proliferation when overexpressed. We wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural features of Mfn2 that influence its mitochondrial localization and control of cell proliferation. Mfn2‐knockdown clones of a B‐cell lymphoma cell
Kuang-Hueih, Chen, Asish, Dasgupta, Jinhui, Ding, Fred E, Indig, Paritosh, Ghosh, Dan L, Longo   +5 more
openaire   +3 more sources

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes

Communications Biology, 2022
AbstractMitochondria and peroxisomes are two types of functionally close-related organelles, and both play essential roles in lipid and ROS metabolism. However, how they physically interact with each other is not well understood. In this study, we apply the proximity labeling method with peroxisomal proteins and report that mitochondrial protein ...
Yinbo Huo, Weiping Sun, Tiezhu Shi, Song Gao, Min Zhuang   +4 more
openaire   +3 more sources