Results 61 to 70 of about 14,571 (197)

Mitofusin-2 Down-Regulation Predicts Progression of Non-Muscle Invasive Bladder Cancer

Diagnostics, 2021
Identification of markers predicting disease outcome is a major clinical issue for non-muscle invasive bladder cancer (NMIBC). The present study aimed to determine the role of the mitochondrial proteins Mitofusin-2 (Mfn2) and caseinolytic protease P ...
Antonella Cormio, Gian Maria Busetto, Clara Musicco, Francesca Sanguedolce, Beppe Calò, Marco Chirico, Ugo Giovanni Falagario, Giuseppe Carrieri, Claudia Piccoli, Luigi Cormio   +9 more
doaj   +1 more source

Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages

Frontiers in Immunology, 2021
Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria.
Vera Khodzhaeva, Yannick Schreiber, Gerd Geisslinger, Gerd Geisslinger, Ralf P. Brandes, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Dmitry Namgaladze   +9 more
doaj   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

Cell Reports, 2020
Summary: Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play a major role in inflammation, we studied the contribution of Mfn2 to the ...
Juan Tur, Selma Pereira-Lopes, Tania Vico, Eros A. Marín, Juan P. Muñoz, Maribel Hernández-Alvarez, Pere-Joan Cardona, Antonio Zorzano, Jorge Lloberas, Antonio Celada   +9 more
doaj   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue

Journal of Clinical Lipidology, 2018
Multiple symmetric lipomatosis (MSL) is characterized by upper-body lipomatous masses frequently associated with metabolic and neurological signs. MFN2 pathogenic variants were recently implicated in a very rare autosomal recessive form of MSL.
Capel, Emilie, Vatier, Camille, Cervera, Pascale, Stojkovic, Tanya, Disse, Emmanuel, Cottereau, Anne-Ségolène, Auclair, Martine, Verpont, Marie-Christine, Mosbah, Héléna, Gourdy, Pierre, Barraud, Sara, Miquel, Anne, Züchner, Stephan, Bonnefond, Amélie, Froguel, Philippe, Christin-Maitre, Sophie, Delemer, Brigitte, Fève, Bruno, Laville, Martine, Robert, Juliette, Tenenbaum, Florence, Lascols, Olivier, Vigouroux, Corinne, Jéru, Isabelle   +23 more
openaire   +3 more sources

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Mfn2 inhibits proliferation and cell-cycle in Hela cells via Ras-NF-κB signal pathway

Cancer Cell International, 2019
Background Mitofusin 2 (Mfn2) is outer membrane protein, as the inhibitor of Ras protein. This study aimed to investigate the effect of Mfn2 on cell proliferation, and cell-cycle in Hela cervical carcinoma cell lines.
Xiaowen Liu, Jun Sun, Ping Yuan, Kangquan Shou, Yuanhong Zhou, Wenqi Gao, Jin She, Jun Hu, Jun Yang, Jian Yang   +9 more
doaj   +1 more source