Results 71 to 80 of about 3,353 (142)

Acupuncture Alleviates Allergic Rhinitis by Activating the AMPK/PGC‐1α Pathway to Attenuate Mitochondrial Oxidative Stress and Restore Epithelial Barrier Function

Flavour and Fragrance Journal, EarlyView.
Acupuncture at Feishu (BL13), Shenshu (BL23), Yingxiang (LI20), and Dazhui (GV14) alleviates allergic rhinitis by activating the AMPK/PGC‐1α/NRF1/TFAM signalling axis. This activation improves mitochondrial biogenesis and function, reduces mtROS‐mediated oxidative stress, restores ATP production and respiratory complex I/IV activity, suppresses IgE and
Fengying Zhang, Wei Meng, Renzhong Wang, Huijun Du   +3 more
wiley   +1 more source

MFN2 mutations cause compensatory mitochondrial DNA proliferation [PDF]

, 2012
MFN2 and OPA1 genes encode two dynamin-like GTPase proteins involved in the fusion of the mitochondrial membrane. They have been associated with Charcot–Marie–Tooth disease type 2A and autosomal dominant optic atrophy, respectively.
Horvath, R, Pyle, Angela, Reilly, Mary M, Horvath, Rita, Seeman, P, Kamil S. Sitarz, Seeman, Pavel, Pavel Seeman, Chinnery, PF, Joanna D. Stewart, Patrick Yu-Wai-Man, Rita Horvath, Reilly, MM, Mary M. Reilly, Pyle, A, Rautenstrauss, B, Stewart, JD, Yu-Wai-Man, Patrick, Angela Pyle, Rautenstrauss, Bernd, Yu-Wai-Man, P, Bernd Rautenstrauss, Sitarz, Kamil S, Stewart, Joanna D, Chinnery, Patrick F, Sitarz, KS, Patrick F. Chinnery   +26 more
core   +2 more sources

Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis. [PDF]

, 2015
Growth factors, energy sources, and mitochondrial function strongly affect embryo growth and development in vitro. The biological role and prospective significance of the mitofusin gene Mfn2 in the development of preimplantation embryos remain poorly ...
Na Zhao, Na Zhao (112953), Qun Liu (67203), Wenpei Xiang (740209), Yong Zhang (5893), Yong Zhang, Qun Liu, Wenpei Xiang   +7 more
core   +1 more source

Preclinical evaluation of candidate “kill or cure” strategies to treat MFN2-related lipodystrophy

Molecular Medicine
Background The mitofusin 2 (MFN2) R707W mutation causes debilitating human lipodystrophy featuring lower body adipose loss, upper body adipose hyperplasia, and dyslipidaemic insulin resistance.
Ineke Luijten, Xiong Weng, Ula Kibildyte, Jana Buchan, Ami Onishi, Jake Mann, Eleanor McKay, David Savage, Robert K. Semple   +8 more
doaj   +1 more source

Phenotypic spectrum of MFN2 mutations in the Spanish population [PDF]

, 2010
INTRODUCTION: The most common form of axonal Charcot-Marie-Tooth (CMT) disease is type 2A, caused by mutations in the mitochondrial GTPase mitofusin 2 (MFN2).
Cassereau, Julien, C. Casasnovas, Casasnovas, C., J.A. Martinez-Matos, D. Bonneau, A. Chevrollier, Banchs, I., Bonneau, Dominique, I. Banchs, Martinez-Matos, J., V. Volpini, J. Cassereau, Gueguen, Naïg, N. Gueguen, Volpini, V., Chevrollier, Arnaud   +15 more
core   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Hormonal stimulation induces Mfn2 expression.

, 2013
MA-10 cells were treated with or without hCG (20 ng/ml) or 8Br-cAMP (1 mM) for the indicated times. A. Total RNA was isolated; reverse-transcribed, and subjected to semi-quantitative PCR using specific primers for Mfn2 and L19 cDNA as loading controls ...
Vanesa Gottifredi (103569), Cecilia Poderoso (38153), Alejandra Duarte (38156), Gastón Soria (306266), Ernesto J. Podestá (38163), Mariana Cooke (306263), Fabiana Cornejo Maciel (38159)   +6 more
core   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

MicroRNA-214 Affects Fibroblast Differentiation of Adipose-Derived Mesenchymal Stem Cells by Targeting Mitofusin-2 during Pelvic Floor Dysfunction in SD Rats with Birth Trauma

Cellular Physiology and Biochemistry, 2017
Background/Aims: This study investigated whether microRNA-214 (miR-214) targets mitofusin-2 (Mfn2) in the process of fibroblast differentiation of adipose-derived mesenchymal stem cells (ADMSCs) during pelvic floor dysfunction (PFD) in Sprague Dawley (SD)
Jing Wu, Jiang Li, Wei-Kang Chen, Shang Liu, Jian-He Liu, Jing-Song Zhang, Ke-Wei Fang   +6 more
doaj   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source