Results 41 to 50 of about 256,048 (301)

Mitochondrial fusion induced by transforming growth factor-β1 serves as a switch that governs the metabolic reprogramming during differentiation of regulatory T cells

Redox Biology, 2023
Although metabolic reprogramming during the differentiation of regulatory T cells (Treg cells) has been extensively studied, the molecular switch to alter energy metabolism remains undefined.
Yulai Fang, Qin Zhang, Changjun Lv, Yilei Guo, Yue He, Pengxiang Guo, Zhifeng Wei, Yufeng Xia, Yue Dai   +8 more
doaj   +1 more source

The PINK1/Parkin pathway: a mitochondrial quality control system? [PDF]

, 2009
Significant insight into the mechanisms that contribute to dopaminergic neurodegeneration in Parkinson disease has been gained from the analysis of genes linked to rare heritable forms of parkinsonism such as PINK1 and parkin, loss-of-function mutations ...
Pallanck, L.J., Whitworth, A.J.
core   +1 more source

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion [PDF]

, 2009
Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the fusion of mammalian mitochondria.
David C. Chan, J. Michael Mccaffery, Janet M. Shaw, Mariam Ghochani, Terrence G. Frey, Zhiyin Song   +5 more
core   +2 more sources

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. [PDF]

, 2018
Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial toxins, many of
Anand, Ruchika, Barbian, Andreas, Berleth, Niklas, Borchardt, Andrea, Böhler, Philip, Böhler, Philip, Deitersen, Jana, Frank, Marian, García-Sáez, Ana J, Itskanov, Samuel, Kondadi, Arun Kumar, Luyten, Tomas, Niemann, Hendrik, Parys, Jan B, Peña-Blanco, Aida, Proksch, Peter, Reichert, Andreas S, Schlütermann, David, Stork, Björn, Stuhldreier, Fabian, van der Bliek, Alexander M, Wallot-Hieke, Nora, Weidtkamp-Peters, Stefanie, Wesbuer, Elisabeth, Wesselborg, Sebastian, Wu, Wenxian   +25 more
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Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.

PLoS ONE, 2008
BackgroundThere is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression.Methodology/principal findingsHere, we demonstrate ...
Marc Liesa, Bárbara Borda-d'Agua, Gema Medina-Gómez, Christopher J Lelliott, José Carlos Paz, Manuel Rojo, Manuel Palacín, Antonio Vidal-Puig, Antonio Zorzano   +8 more
doaj   +1 more source

Integrating multiple aspects of mitochondrial dynamics in neurons: Age-related differences and dynamic changes in a chronic rotenone model

Neurobiology of Disease, 2011
Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold, Steven J. Cassady, Victor S. VanLaar, Sarah B. Berman   +3 more
doaj   +1 more source

Plant mitochondrial fission and fusion

Plant Biotechnology, 2005
Single plant cells have hundreds of mitochondria that move around and change their shape through the processes of fission and fusion. The Arabidopsis genome has genes for two dynamin-related proteins, DRP3A and DRP3B, that are similar to genes involved in mitochondrial fission in yeasts. DRP3A and DRP3B were localized to mitochondrial constricted sites
Shin-Ichi, Arimura, Nobuhiro, Tsutsumi
openaire   +3 more sources

Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy [PDF]

, 2015
Defects in mitochondrial fusion or fission are associated with many pathologies, raising the hope that pharmacological manipulation of mitochondrial dynamics may have therapeutic benefit.
Agah, Alexander, Brand, Cassidy-Stone, Chen, Chen, Chen, Chen, Chen, Clary Clish, David C. Chan, Delettre, Dorn, Friedman, Gandre-Babbe, Harvey, Hayashi, Hsiuchen Chen, Ikeda, Ishihara, J. Michael McCaffery, Kageyama, Kasahara, Lopaschuk, Losón, Mishra, Mohit Jain, Otera, Papanicolaou, Postic, Qi, Sadate-Ngatchou, Shamseldin, Shuxun Ren, Song, Vamsi Mootha, Wakabayashi, Waterham, Züchner   +38 more
core   +4 more sources

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research [PDF]

, 2015
Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood.
Ainscow, Amchenkova, Bakeeva, Bazil, Beard, Bernardi, Brand, Braschi, Busch, Cagalinec, Castanier, Chan, Chen, Chen, Chen, Chouhan, Cipolat, Cortassa, das Neves, De Marchi, Dedkova, Denton, Denton, Ehses, Estaquier, Figge, Fischer, Frezza, Friedman, Gilkerson, Gilkerson, Gomes, Gottlieb, Grandemange, Groen, Harrison, Head, Hemion, Imai, Jahani-Asl, Jahani-Asl, Jimenez, Johnston, Johnston, Junesch, Kim, Kowald, Krapivsky, Laar, Lee, Legros, Lemasters, Liesa, Liu, Liu, Logan, Magnus, Mai, Malli, Maltecca, McBride, McCormack, Meeusen, Mishra, Mitra, Mitra, Mouli, Murphy, Nakada, Narendra, Neuspiel, Olichon, Ong, Ono, Parone, Partikian, Patel, Patergnani, Patten, Picard, Picard, Qian, Rafelski, Rafelski, Rambold, Rizzuto, Rizzuto, Rodell, Rolland, Saa, Sahimi, Skulachev, Skulachev, Soboll, Soga, Song, Soubannier, Stauffer, Sukhorukov, Szabadkai, Tondera, Twig, Twig, van der Bliek, Verkman, Vinnakota, Viola, Wan, Westrate, Wikstrom, Wikstrom, Wilkens, Wu, Wu, Youle, Zemirli, Zhang, Zhu   +117 more
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Bioenergetic roles of mitochondrial fusion

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016
Mitochondria are bioenergetic hotspots, producing the bulk of ATP by the oxidative phosphorylation process. Mitochondria are also structurally dynamic and undergo coordinated fusion and fission to maintain their function. Recent studies of the mitochondrial fusion machinery have provided new evidence in detailing their role in mitochondrial metabolism.
Ramos, E., Larsson, N., Mourier, A.
openaire   +3 more sources