Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders
Membranes, 2022 Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission
Mode Al Ojaimi +2 more
doaj +4 more sources
Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review [PDF]
World Journal of Surgical Oncology, 2022 Background Mitochondria play critical roles in cellular physiological activity as cellular organelles. Under extracellular stimulation, mitochondria undergo constant fusion and fission to meet different cellular demands. Mitochondrial dynamics, which are
Jixiang Xing +5 more
doaj +2 more sources
Mitochondrial morphological features are associated with fission and fusion events. [PDF]
PLoS ONE, 2014 Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial fission and fusion.
Laura M Westrate +4 more
doaj +2 more sources
Inhibition of mitochondrial dynamics in Dictyostelium discoideum through the overexpression of FszA and FszB proteins [PDF]
Frontiers in Cell and Developmental BiologyMitochondria play a central role in cells through energy production, calcium regulation, and cell death regulation. Dysfunction of mitochondria can impair energy production causing cellular damage which could be detrimental to an organism.
Ashley Ryan, Kari Naylor
doaj +2 more sources
Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity
Neurobiology of Disease, 2016 Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate adaptation to energetic needs, keeps mitochondria in good health ...
A.M. Bertholet +11 more
doaj +3 more sources
Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation [PDF]
Cell Death and DiseaseMitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood.
Daniel Lagos +8 more
doaj +2 more sources
Mitochondrial fusion–fission dynamics and its involvement in colorectal cancer
Molecular OncologyThe incidence and mortality rates of colorectal cancer have elevated its status as a significant public health concern. Recent research has elucidated the crucial role of mitochondrial fusion–fission dynamics in the initiation and progression of ...
Zihong Wu +5 more
doaj +2 more sources
Mitochondrial Dynamics in Cancer Progression and Therapy Resistance: Emerging Roles in Metabolic Reprogramming, Biomarker Discovery, and Precision Medicine [PDF]
CellsMitochondria play essential roles in cellular metabolism and signaling, regulating biosynthetic pathways, calcium homeostasis, redox balance, and cell fate beyond ATP production. Their continual remodeling through fusion, fission, and mitophagy maintains
Vasudevarao Penugurti +2 more
doaj +2 more sources
BMC Biology, 2021 Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins.
Rong Yu +6 more
doaj +1 more source
The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury
Biomolecules, 2021 Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study the temporal dynamics of mitochondrial fusion and fission, we observed the alteration of mitochondrial ...
Yunsi Zheng, Anqi Luo, Xiaoquan Liu
doaj +1 more source