Results 1 to 10 of about 34,113 (275)
Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders
Membranes, 2022 Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission
Mode Al Ojaimi +2 more
doaj +4 more sources
Mitochondrial Fusion and Fission in Mammals [PDF]
Annual Review of Cell and Developmental Biology, 2006 Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial fragmentation, and unbalanced fusion leads to mitochondrial elongation.
David C Chan
exaly +5 more sources
Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review [PDF]
World Journal of Surgical Oncology, 2022 Background Mitochondria play critical roles in cellular physiological activity as cellular organelles. Under extracellular stimulation, mitochondria undergo constant fusion and fission to meet different cellular demands. Mitochondrial dynamics, which are
Jixiang Xing +5 more
doaj +2 more sources
Targeting mitochondrial fusion and fission proteins for cardioprotection. [PDF]
J Cell Mol Med, 2020 AbstractNew treatments are needed to protect the myocardium against the detrimental effects of acute ischaemia/reperfusion (IR) injury following an acute myocardial infarction (AMI), in order to limit myocardial infarct (MI) size, preserve cardiac function and prevent the onset of heart failure (HF).
Hernandez-Resendiz S +5 more
europepmc +6 more sources
Mitochondrial fusion, fission, and mitochondrial toxicity [PDF]
Toxicology, 2017 Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and function, and are increasingly ...
Joel N Meyer, Anthony L Luz
exaly +3 more sources
Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery. [PDF]
Cells, 2020 Mitochondrial fusion and fission tailors the mitochondrial shape to changes in cellular homeostasis. Players of this process are the mitofusins, which regulate fusion of the outer mitochondrial membrane, and the fission protein DRP1. Upon specific stimuli, DRP1 translocates to the mitochondria, where it interacts with its receptors FIS1, MFF, and MID49/
Wolf C +7 more
europepmc +6 more sources
Mitochondrial fission/fusion dynamics and apoptosis [PDF]
Mitochondrion, 2010 Mitochondria play an important role in the progression of apoptosis through the release of pro-apoptotic factors, such as cytochrome c, from the mitochondrial intermembrane space. During this process, mitochondrial networks are dramatically reorganised from long filamentous interconnected tubules into small punctate spheres.
Clare Sheridan, Seamus J Martin
exaly +4 more sources
Mitochondrial Fission and Fusion in Tumor Progression to Metastasis
Frontiers in Cell and Developmental Biology, 2022 Mitochondria are highly dynamic organelles which can change their shape, via processes termed fission and fusion, in order to adapt to different environmental and developmental contexts. Due to the importance of these processes in maintaining a physiologically healthy pool of mitochondria, aberrant cycles of fission/fusion are often seen in ...
Dillon P Boulton +2 more
exaly +4 more sources
Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity
Neurobiology of Disease, 2016 Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate adaptation to energetic needs, keeps mitochondria in good health ...
A.M. Bertholet +11 more
doaj +3 more sources
Mitochondrial fission and fusion dynamics: the long and short of it [PDF]
Cell Death and Differentiation, 2008 Maintenance of functional mitochondria requires fusion and fission of these dynamic organelles. The proteins that regulate mitochondrial dynamics are now associated with a broad range of cellular functions. Mitochondrial fission and fusion are often viewed as a finely tuned balance within cells, yet an integrated and quantitative understanding of how ...
Sarah B Berman, J Marie Hardwick
exaly +3 more sources