Mitochondrial morphological features are associated with fission and fusion events. [PDF]
PLoS ONE, 2014 Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial fission and fusion.
Laura M Westrate +4 more
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Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. [PDF]
PLoS Computational Biology, 2012 Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Marc Thilo Figge +3 more
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Mitochondrial fission and fusion [PDF]
Essays in Biochemistry, 2010 Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the ...
Iain, Scott, Richard J, Youle
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Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. [PDF]
PLoS ONE, 2011 Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change.
Pinwei Huang +2 more
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The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury
Biomolecules, 2021 Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study the temporal dynamics of mitochondrial fusion and fission, we observed the alteration of mitochondrial ...
Yunsi Zheng, Anqi Luo, Xiaoquan Liu
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Emergence of the Mitochondrial Reticulum from Fission and Fusion Dynamics
PLoS Computational Biology, 2012 Mitochondria form a dynamic tubular reticulum within eukaryotic cells. Currently, quantitative understanding of its morphological characteristics is largely absent, despite major progress in deciphering the molecular fission and fusion machineries shaping its structure. Here we address the principles of formation and the large-scale organization of the
Valerii M. Sukhorukov +3 more
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Multi-patterned dynamics of mitochondrial fission and fusion in a living cell. [PDF]
PLoS ONE, 2012 Mitochondria are highly-dynamic organelles, but it is challenging to monitor quantitatively their dynamics in a living cell. Here we developed a novel approach to determine the global occurrence of mitochondrial fission and fusion events in living human ...
Shiqi Wang +10 more
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TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. [PDF]
PLoS ONE, 2012 Mitochondria are dynamic organelles that change in response to extracellular stimuli. These changes are essential for normal mitochondrial/cellular function and are controlled by a tight balance between two antagonistic pathways that promote fusion and ...
Hironori Takamura +8 more
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Bioenergetic role of mitochondrial fusion and fission
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012 Mitochondria are highly dynamic organelles. Frequent cycles of fusion and fission adapt the morphology of the mitochondrial compartment to the metabolic needs of the cell. Mitochondrial fusion is particularly important in respiratory active cells. It allows the spreading of metabolites, enzymes, and mitochondrial gene products throughout the entire ...
Westermann, Benedikt
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The Role of Abnormal Mitochondrial Fusion and Fission in the Inflammatory Senescence of Dental Pulp Stem Cells [PDF]
International Dental JournalAim: The regeneration ability of dental pulp stem cells (DPSCs) is essential for vital pulp preservation therapy, but may be disrupted by inflammatory senescence.
Wenyue Tang +9 more
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