Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. [PDF]
PLoS Computational Biology, 2012 Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Marc Thilo Figge +3 more
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Mitochondrial fission and fusion [PDF]
Essays in Biochemistry, 2010 Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of ...
Richard J. Youle, Iain Scott
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Emergence of the mitochondrial reticulum from fission and fusion dynamics [PDF]
PLoS Computational Biology, 2012 Mitochondria form a dynamic tubular reticulum within eukaryotic cells. Currently, quantitative understanding of its morphological characteristics is largely absent, despite major progress in deciphering the molecular fission and fusion machineries ...
Michael Meyer-Hermann +13 more
core +6 more sources
Bioenergetic role of mitochondrial fusion and fission [PDF]
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012 Mitochondria are highly dynamic organelles. Frequent cycles of fusion and fission adapt the morphology of the mitochondrial compartment to the metabolic needs of the cell. Mitochondrial fusion is particularly important in respiratory active cells.
Westermann, Benedikt
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Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. [PDF]
PLoS ONE, 2011 Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change.
Pinwei Huang +2 more
doaj +2 more sources
Multi-patterned dynamics of mitochondrial fission and fusion in a living cell. [PDF]
PLoS ONE, 2012 Mitochondria are highly-dynamic organelles, but it is challenging to monitor quantitatively their dynamics in a living cell. Here we developed a novel approach to determine the global occurrence of mitochondrial fission and fusion events in living human ...
Shiqi Wang +10 more
doaj +2 more sources
Mechanisms of Mitochondrial Fusion and Fission [PDF]
, 2006 We have studied the mechanisms of mitochondrial fusion and fission in S. cerevisiae. Using a proteomics-based approach, we have identified the WD domain protein Caf4p as a Fis1p binding partner that, along with its paralog Mdv1p, functions as a ...
Griffin, Erik Edmund
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Microtubules are Essential for Mitochondrial Dynamics-Fission, Fusion, and Motility- in Dictyostelium discoideum. [PDF]
Frontiers in Cell and Developmental Biology, 2016 Mitochondrial function is dependent upon mitochondrial structure which is in turn dependent upon mitochondrial dynamics, including fission, fusion, and motility.
Laken C. Woods +2 more
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Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
Annual Review of Genetics, 2012 Mitochondria are dynamic organelles that continually undergo fusion and fission. These opposing processes work in concert to maintain the shape, size, and number of mitochondria and their physiological function.
David C. Chan
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Targeting mitochondrial fusion and fission proteins for cardioprotection. [PDF]
J Cell Mol Med, 2020 AbstractNew treatments are needed to protect the myocardium against the detrimental effects of acute ischaemia/reperfusion (IR) injury following an acute myocardial infarction (AMI), in order to limit myocardial infarct (MI) size, preserve cardiac function and prevent the onset of heart failure (HF).
Hernandez-Resendiz S +5 more
europepmc +6 more sources