Results 31 to 40 of about 34,113 (275)
Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer
Breast Cancer Research, 2020 Background Mitochondrial dynamics underlies malignant transformation, cancer progression, and response to treatment. Current research presents conflicting evidence for functions of mitochondrial fission and fusion in tumor progression.
Brock A. Humphries +21 more
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An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
eLife, 2022 Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCSs). These MCSs or nodes co-localize fission and fusion machinery. We set out
Tricia T Nguyen, Gia K Voeltz
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Metabolic consequences of neuronal mitochondrial fission ablation [PDF]
, 2016 Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
core +1 more source
Neurobiology of Disease, 2011 Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold +3 more
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New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics
Frontiers in Endocrinology, 2023 As important organelles of energetic and metabolism, changes in the dynamic state of mitochondria affect the homeostasis of cellular metabolism. Mitochondrial dynamics include mitochondrial fusion and mitochondrial fission.
Shengnan Wang +7 more
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Neurodegenerative stress related mitochondrial proteostasis [PDF]
, 2015 1.1 Background: Mitochondria are the main site of energy production in most cells. Furthermore, they are involved in a multitude of other essential cellular processes, such as regulating the cellular calcium pool, lipid metabolism and programmed cell ...
Fang, Lei
core +1 more source
Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]
, 2014 Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Role of GTPase-Dependent Mitochondrial Dynamins in Heart Diseases
Frontiers in Cardiovascular Medicine, 2021 Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria. In addition to providing energy to cardiomyocytes, mitochondria also play an important role in maintaining cell function and homeostasis.
Jiangen Liu +3 more
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Plant mitochondrial fission and fusion
Plant Biotechnology, 2005 Single plant cells have hundreds of mitochondria that move around and change their shape through the processes of fission and fusion. The Arabidopsis genome has genes for two dynamin-related proteins, DRP3A and DRP3B, that are similar to genes involved in mitochondrial fission in yeasts. DRP3A and DRP3B were localized to mitochondrial constricted sites
Arimura, Shin-ichi, Tsutsumi, Nobuhiro
openaire +3 more sources