Results 31 to 40 of about 36,753 (273)

Respiratory chain complexes in dynamic mitochondria display a patchy distribution in life cells [PDF]

, 2010
Background: Mitochondria, the main suppliers of cellular energy, are dynamic organelles that fuse and divide frequently. Constraining these processes impairs mitochondrial is closely linked to certain neurodegenerative diseases.
Strecker, V., Busch, K., Winfried Haase, Wittig, I., Bereiter-Hahn, Jürgen, Haase, W., Karin Busch, Joos, Friederike, Ilka Wittig, Britta Muster, Jürgen Bereiter-Hahn, Wittig, Ilka, Wladislaw Kohl, Valentina Strecker, Busch, Karin, Haase, Winfried, Joos, F., Muster, Britta, Kohl, W., Strecker, Valentina, Friederike Joos, Muster, B., Bereiter-Hahn, J., Kohl, Wladislaw   +23 more
core   +2 more sources

Integrating multiple aspects of mitochondrial dynamics in neurons: Age-related differences and dynamic changes in a chronic rotenone model

Neurobiology of Disease, 2011
Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold, Steven J. Cassady, Victor S. VanLaar, Sarah B. Berman   +3 more
doaj   +1 more source

Neurodegenerative stress related mitochondrial proteostasis [PDF]

, 2015
1.1 Background: Mitochondria are the main site of energy production in most cells. Furthermore, they are involved in a multitude of other essential cellular processes, such as regulating the cellular calcium pool, lipid metabolism and programmed cell ...
Fang, Lei
core   +1 more source

An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion

eLife, 2022
Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCSs). These MCSs or nodes co-localize fission and fusion machinery. We set out
Tricia T Nguyen, Gia K Voeltz
doaj   +1 more source

Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]

, 2014
Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core   +1 more source

Role of GTPase-Dependent Mitochondrial Dynamins in Heart Diseases

Frontiers in Cardiovascular Medicine, 2021
Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria. In addition to providing energy to cardiomyocytes, mitochondria also play an important role in maintaining cell function and homeostasis.
Jiangen Liu, Xianjing Song, Youyou Yan, Bin Liu   +3 more
doaj   +1 more source

Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor. [PDF]

, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Maddock Helen, Hussain, Afthab, Gharanei Mayel, Maddock, H, Janneh, Omar, Omar Janneh, Maddock, Helen L., Helen Maddock, Hussain, A, Gharanei, M., Hussain Afthab, Afthab Hussain, Janneh, O, Mayel Gharanei, Janneh Omar, Gharanei, M   +15 more
core   +2 more sources

Mitochondrial fission/fusion and cardiomyopathy [PDF]

Current Opinion in Genetics & Development, 2016
Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist.
openaire   +2 more sources

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration [PDF]

, 2009
Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive ...
Rüb Udo, Jendrach, M., Wenzel, Dirk, Auburger Georg, Miguel Barrera, Nussbaum, Robert L, Leuner, K., Hoepken, Hans Hermann, Amy Chen, Kudin, Alexei P, Auburger, Georg, Mekhman Azizov, Zimmermann, Annabelle, Zimmerman, Annabelle, Fernández-Ruiz, Javier, Dorothea Becker, Nussbaum, R., Becker, D., Auburger, G., Gispert, Suzana, Zimmermann Annabelle, Hoepken, Hans-Hermann, Nussbaum, Robert L., Robert L Nussbaum, Hoepken, H., Müller Walter E., Leslie Huber, Müller, Walter E., Gispert Suzana, García-Arencíbia, Moisés, Roeper Jochen, Ricciardi Filomena, Jendrach Marina, Dirk Wenzel, Kurz, A., Kurz Alexander, Voos, W., Azizov Mekhman, Kunz Wolfram S., Kurz, Alexander, Jendrach, Marina, Jochen Roeper, Müller, W., Wenzel, D., Rohrer, Hermann, Gispert, S., Hoepken Hans-Hermann, Azizov, M., Andreas S Reichert, Udo Rüb, Voos, Wolfgang, Reichert, Andreas S., Kristina Leuner, Rohrer, H., Kunz, Wolfram S, Javier Fernández-Ruiz, Barrera Miguel, Rüb, Udo, Wenzel Dirk, Chen Amy, Becker Dorothea, Rüb, U., Marina Jendrach, Müller, Walter E, Chen, A., Barrera, Miguel, Moisés García-Arencíbia, Fernández-Ruiz Javier, Wolfram S Kunz, Kudin, Alexei P., Reichert, A., Annabelle Zimmermann, Fernández-Ruiz, J., Kunz, W., Leuner Kristina, Rohrer Hermann, Alexander Kurz, Reichert Andreas S., Alexei P Kudin, Hermann Rohrer, Azizov, Mekhman, Reichert, Andreas, Zimmermann, A., Walter E Müller, Barrera, M., García-Arencíbia Moisés, Nussbaum Robert L., Roeper, Jochen, Chen, Amy, Filomena Ricciardi, Hans-Hermann Hoepken, Kudin Alexei P., Huber, L., Suzana Gispert, García-Arencíbia, M., Becker, Dorothea, Reichert, Andreas S, Georg Auburger, Huber Leslie, Ricciardi, Filomena, Ricciardi, F., Kunz, Wolfram S., Kudin, A., Leuner, Kristina, Roeper, J., Wolfgang Voos, Voos Wolfgang, Huber, Leslie   +107 more
core   +1 more source

New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics

Frontiers in Endocrinology, 2023
As important organelles of energetic and metabolism, changes in the dynamic state of mitochondria affect the homeostasis of cellular metabolism. Mitochondrial dynamics include mitochondrial fusion and mitochondrial fission.
Shengnan Wang, Haiyang Zhao, Suxian Lin, Yang Lv, Yue Lin, Yinai Liu, Renyi Peng, Huanzhi Jin   +7 more
doaj   +1 more source