Results 51 to 60 of about 53,504 (295)

Role of mitochondrial fission and fusion in cardiomyocyte contractility [PDF]

International Journal of Cardiology, 2015
Mitochondria constitute 30% of cell volume and are engaged in two dynamic processes called fission and fusion, regulated by Drp-1 (dynamin related protein) and mitofusin 2 (Mfn2). Previously, we showed that Drp-1 inhibition attenuates cardiovascular dysfunction following pressure overload in aortic banding model and myocardial infarction.
S, Givvimani, S B, Pushpakumar, N, Metreveli, S, Veeranki, S, Kundu, S C, Tyagi   +5 more
openaire   +2 more sources

Microtubules are Essential for Mitochondrial Dynamics-Fission, Fusion, and Motility- in Dictyostelium discoideum.

Frontiers in Cell and Developmental Biology, 2016
Mitochondrial function is dependent upon mitochondrial structure which is in turn dependent upon mitochondrial dynamics, including fission, fusion, and motility.
Laken C. Woods, Gregory W. Berbusse, Kari eNaylor   +2 more
doaj   +1 more source

Super-Resolution Quantification of T2DM-Induced Mitochondrial Morphology Changes and Their Implications in Pharmacodynamics of Metformin and Sorafenib

Frontiers in Pharmacology, 2022
Mitochondria, as the powerhouse of cells, are involved in various processes of cellular homeostasis, especially energy metabolism. The morphology of mitochondria is a critical indicator for their functions, referring to mitochondrial fusion and fission ...
Yang Du, Ya-Juan Zhu, Bo Zeng, Xiao-Li Mu, Ji-Yan Liu   +4 more
doaj   +1 more source

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research [PDF]

, 2015
Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood.
Ainscow, Amchenkova, Bakeeva, Bazil, Beard, Bernardi, Brand, Braschi, Busch, Cagalinec, Castanier, Chan, Chen, Chen, Chen, Chouhan, Cipolat, Cortassa, das Neves, De Marchi, Dedkova, Denton, Denton, Ehses, Estaquier, Figge, Fischer, Frezza, Friedman, Gilkerson, Gilkerson, Gomes, Gottlieb, Grandemange, Groen, Harrison, Head, Hemion, Imai, Jahani-Asl, Jahani-Asl, Jimenez, Johnston, Johnston, Junesch, Kim, Kowald, Krapivsky, Laar, Lee, Legros, Lemasters, Liesa, Liu, Liu, Logan, Magnus, Mai, Malli, Maltecca, McBride, McCormack, Meeusen, Mishra, Mitra, Mitra, Mouli, Murphy, Nakada, Narendra, Neuspiel, Olichon, Ong, Ono, Parone, Partikian, Patel, Patergnani, Patten, Picard, Picard, Qian, Rafelski, Rafelski, Rambold, Rizzuto, Rizzuto, Rodell, Rolland, Saa, Sahimi, Skulachev, Skulachev, Soboll, Soga, Song, Soubannier, Stauffer, Sukhorukov, Szabadkai, Tondera, Twig, Twig, van der Bliek, Verkman, Vinnakota, Viola, Wan, Westrate, Wikstrom, Wikstrom, Wilkens, Wu, Wu, Youle, Zemirli, Zhang, Zhu   +117 more
core   +2 more sources

Mitochondrial fission and fusion in Dictyostelium discoideum: a search for proteins involved in membrane dynamics

BMC Research Notes, 2012
Background Mitochondrial morphology is maintained by two distinct membrane events -fission and fusion. Altering these conserved processes can disrupt mitochondrial morphology and distribution, thereby disrupting the organelle’s functionality and impeding
Schimmel Brixey G, Berbusse Gregory W, Naylor Kari   +2 more
doaj   +1 more source

ER-mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release. [PDF]

, 2017
The formin-like protein INF2 is an important player in the polymerization of actin filaments. In this issue, Chakrabarti et al. (2018. J. Cell Biol.
Koehler, Carla M, Steffen, Janos
core   +1 more source

Characterisation of cold-induced mitochondrial fission in porcine aortic endothelial cells

Molecular Medicine, 2022
Background Previously, we observed that hypothermia, widely used for organ preservation, elicits mitochondrial fission in different cell types. However, temperature dependence, mechanisms and consequences of this cold-induced mitochondrial fission are ...
Leonard Quiring, Björn Walter, Niklas Lohaus, Dhanusha Schwan, Anja Rech, Andrea Dlugos, Ursula Rauen   +6 more
doaj   +1 more source

All-Trans Retinoic Acid Increases DRP1 Levels and Promotes Mitochondrial Fission

Cells, 2021
In the heart, mitochondrial homeostasis is critical for sustaining normal function and optimal responses to metabolic and environmental stressors.
Bojjibabu Chidipi, Syed Islamuddin Shah, Michelle Reiser, Manasa Kanithi, Amanda Garces, Byeong J. Cha, Ghanim Ullah, Sami F. Noujaim   +7 more
doaj   +1 more source

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]

, 2017
The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías, Cromberg, Lucas Eneas, Dimopoulos, Nicolás, Falzone, Tomas Luis, Marin Burgin, Antonia, Otero, Maria Gabriela, Pardi, María Belén, Pozo Devoto, Victorio Martin, Saez, Trinidad María de Los Milagros, Scassa, Maria Elida, Schinder, Alejandro Fabián, Sevlever, Gustavo, Stokin, Gorazd B.   +12 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source