Results 41 to 50 of about 34,113 (275)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor. [PDF]

, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Maddock Helen, Hussain, Afthab, Gharanei Mayel, Maddock, H, Janneh, Omar, Omar Janneh, Maddock, Helen L., Helen Maddock, Hussain, A, Gharanei, M., Hussain Afthab, Afthab Hussain, Janneh, O, Mayel Gharanei, Janneh Omar, Gharanei, M   +15 more
core   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration [PDF]

, 2009
Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive ...
Rüb Udo, Jendrach, M., Wenzel, Dirk, Auburger Georg, Miguel Barrera, Nussbaum, Robert L, Leuner, K., Hoepken, Hans Hermann, Amy Chen, Kudin, Alexei P, Auburger, Georg, Mekhman Azizov, Zimmermann, Annabelle, Zimmerman, Annabelle, Fernández-Ruiz, Javier, Dorothea Becker, Nussbaum, R., Becker, D., Auburger, G., Gispert, Suzana, Zimmermann Annabelle, Hoepken, Hans-Hermann, Nussbaum, Robert L., Robert L Nussbaum, Hoepken, H., Müller Walter E., Leslie Huber, Müller, Walter E., Gispert Suzana, García-Arencíbia, Moisés, Roeper Jochen, Ricciardi Filomena, Jendrach Marina, Dirk Wenzel, Kurz, A., Kurz Alexander, Voos, W., Azizov Mekhman, Kunz Wolfram S., Kurz, Alexander, Jendrach, Marina, Jochen Roeper, Müller, W., Wenzel, D., Rohrer, Hermann, Gispert, S., Hoepken Hans-Hermann, Azizov, M., Andreas S Reichert, Udo Rüb, Voos, Wolfgang, Reichert, Andreas S., Kristina Leuner, Rohrer, H., Kunz, Wolfram S, Javier Fernández-Ruiz, Barrera Miguel, Rüb, Udo, Wenzel Dirk, Chen Amy, Becker Dorothea, Rüb, U., Marina Jendrach, Müller, Walter E, Chen, A., Barrera, Miguel, Moisés García-Arencíbia, Fernández-Ruiz Javier, Wolfram S Kunz, Kudin, Alexei P., Reichert, A., Annabelle Zimmermann, Fernández-Ruiz, J., Kunz, W., Leuner Kristina, Rohrer Hermann, Alexander Kurz, Reichert Andreas S., Alexei P Kudin, Hermann Rohrer, Azizov, Mekhman, Reichert, Andreas, Zimmermann, A., Walter E Müller, Barrera, M., García-Arencíbia Moisés, Nussbaum Robert L., Roeper, Jochen, Chen, Amy, Filomena Ricciardi, Hans-Hermann Hoepken, Kudin Alexei P., Huber, L., Suzana Gispert, García-Arencíbia, M., Becker, Dorothea, Reichert, Andreas S, Georg Auburger, Huber Leslie, Ricciardi, Filomena, Ricciardi, F., Kunz, Wolfram S., Kudin, A., Leuner, Kristina, Roeper, J., Wolfgang Voos, Voos Wolfgang, Huber, Leslie   +107 more
core   +1 more source

Mitochondrial fission/fusion and cardiomyopathy [PDF]

Current Opinion in Genetics & Development, 2016
Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist.
openaire   +2 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Drp1 ablation in the adult mouse forebrain [PDF]

, 2014
Due to their high energy demand, their highly polarized nature and the sheer length of their processes, neurons - more than any other cell type - depend on a well-balanced dynamic mitochondrial network.
Oettinghaus, Bjorn
core   +1 more source

Structure and function of bacterial dynamin-like proteins [PDF]

, 2012
Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core   +1 more source

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]

, 2015
Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Jan-Willem Taanman, Shamima Rahman, Laura D. Osellame, Gilmour, Kimberley, Glenn Anderson, Jacques, Thomas S, Sophie Hambleton, Cale, Catherine, Osellame, Laura, Plagnol, Vincent, Chalasani, A, Annapurna Chalasani, Gilmour, KC, Hambleton, Sophie, Wedatilake, Yehani, Gilmour, Kimberley C, Duchen, Michael R, Osellame, LD, Taanman, Jan-Willem, Jacques, S, Vincent Plagnol, Plagnol, V, Rahman, S, Yehani Wedatilake, Michael R. Duchen, Shahni, Rojeen, Qasim, Waseem, Thomas S. Jacques, Catherine M. Cale, Duchen, Michael, Cale, Catherine M, Waseem Qasim, Anderson, Glenn, Wadatilake, Y, Cale, CM, Rahman, Shamima, Osellame, Laura D, Taanman, JW, Chan, E, Jacques, Thomas, Anderson, G, Rojeen Shahni, Chalasani, Annapurna, Kimberly C. Gilmour, Qasim, W, Emma Chan, Hambleton, S, Duchen, MR, Shahni, R, Chan, Emma   +49 more
core   +1 more source

Role of mitochondrial fission and fusion in cardiomyocyte contractility [PDF]

International Journal of Cardiology, 2015
Mitochondria constitute 30% of cell volume and are engaged in two dynamic processes called fission and fusion, regulated by Drp-1 (dynamin related protein) and mitofusin 2 (Mfn2). Previously, we showed that Drp-1 inhibition attenuates cardiovascular dysfunction following pressure overload in aortic banding model and myocardial infarction.
S, Givvimani, S B, Pushpakumar, N, Metreveli, S, Veeranki, S, Kundu, S C, Tyagi   +5 more
openaire   +2 more sources