Results 21 to 30 of about 34,113 (275)

Microtubules are Essential for Mitochondrial Dynamics-Fission, Fusion, and Motility- in Dictyostelium discoideum.

Frontiers in Cell and Developmental Biology, 2016
Mitochondrial function is dependent upon mitochondrial structure which is in turn dependent upon mitochondrial dynamics, including fission, fusion, and motility.
Laken C. Woods, Gregory W. Berbusse, Kari eNaylor   +2 more
doaj   +2 more sources

Mitochondrial Dynamics in Cancer Progression and Therapy Resistance: Emerging Roles in Metabolic Reprogramming, Biomarker Discovery, and Precision Medicine [PDF]

Cells
Mitochondria play essential roles in cellular metabolism and signaling, regulating biosynthetic pathways, calcium homeostasis, redox balance, and cell fate beyond ATP production. Their continual remodeling through fusion, fission, and mitophagy maintains
Vasudevarao Penugurti, Rajni Kant, Che-Chia Hsu   +2 more
doaj   +2 more sources

Emerging functions of mammalian mitochondrial fusion and fission [PDF]

Human Molecular Genetics, 2005
Mitochondria provide a myriad of services to the cell, including energy production, calcium buffering and regulation of apoptosis. How these diverse functions are coordinated among the hundreds of mitochondria in a given cell is largely unknown, but is probably dependent on the dynamic nature of mitochondria.
Hsiuchen, Chen, David C, Chan
openaire   +4 more sources

Mitochondrial fusion–fission dynamics and its involvement in colorectal cancer

Molecular Oncology
The incidence and mortality rates of colorectal cancer have elevated its status as a significant public health concern. Recent research has elucidated the crucial role of mitochondrial fusion–fission dynamics in the initiation and progression of ...
Zihong Wu, Chong Xiao, Fang Li, Wenbo Huang, Fengming You, Xueke Li   +5 more
doaj   +2 more sources

MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries

BMC Biology, 2021
Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins.
Rong Yu, Tong Liu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Monica Nistér, Jian Zhao   +6 more
doaj   +1 more source

Mitochondrial Fission, Fusion, and Stress [PDF]

Science, 2012
Mitochondrial Dynamics Mitochondria—the powerhouses of the cell—are autonomous organelles with their own genomes. Within cells, mitochondria are remarkably dynamic, continually moving around the cytoplasm and undergoing fusion and fission reactions. Youle and van der Bliek (p. 1062 )
Richard J, Youle, Alexander M, van der Bliek   +1 more
openaire   +2 more sources

Mechanisms of Mitochondrial Fission and Fusion [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Mitochondria continually change shape through the combined actions of fission, fusion, and movement along cytoskeletal tracks. The lengths of mitochondria and the degree to which they form closed networks are determined by the balance between fission and fusion rates. These rates are influenced by metabolic and pathogenic conditions inside mitochondria
Alexander M, van der Bliek, Qinfang, Shen, Sumihiro, Kawajiri   +2 more
openaire   +2 more sources

The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases

Cells, 2023
Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular calcium
Pierce Colpman, Asish Dasgupta, Stephen L. Archer   +2 more
doaj   +1 more source

Dose-Dependent Response to the Environmental Pollutant Dichlorodipheniletylhene (DDE) in HepG2 Cells: Focus on Cell Viability and Mitochondrial Fusion/Fission Proteins

Toxics, 2021
Dichlorodiphenyldichloroethylene (DDE), the primary persistent metabolite of dichlorodiphenyltrichloroethane (DDT), has toxic effects on cells, but its dose-dependent impact on mitochondrial proteins involved in mitochondrial fusion and fission processes
Mario Alberto Burgos Aceves, Vincenzo Migliaccio, Marilena Lepretti, Gaetana Paolella, Ilaria Di Gregorio, Serena Penna, Caterina Faggio, Lillà Lionetti   +7 more
doaj   +1 more source

Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance. [PDF]

PLoS ONE, 2013
Accumulation of mitochondrial DNA (mtDNA) mutations has been implicated in a wide range of human pathologies, including neurodegenerative diseases, sarcopenia, and the aging process itself.
Zhi Yang Tam, Jan Gruber, Barry Halliwell, Rudiyanto Gunawan   +3 more
doaj   +1 more source