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Unraveling the Mechanism of ER-Associated Mitochondrial Fission and Fusion [PDF]
, 2022 Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCSs). These MCSs or nodes co-localize fission and fusion machinery.
Nguyen, Tricia Thuy-Trang
core +7 more sources
Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery. [PDF]
Cells, 2020 Mitochondrial fusion and fission tailors the mitochondrial shape to changes in cellular homeostasis. Players of this process are the mitofusins, which regulate fusion of the outer mitochondrial membrane, and the fission protein DRP1. Upon specific stimuli, DRP1 translocates to the mitochondria, where it interacts with its receptors FIS1, MFF, and MID49/
Wolf C +7 more
europepmc +6 more sources
Mechanisms of Mitochondrial Fission and Fusion [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Mitochondria continually change shape through the combined actions of fission, fusion, and movement along cytoskeletal tracks. The lengths of mitochondria and the degree to which they form closed networks are determined by the balance between fission and fusion rates. These rates are influenced by metabolic and pathogenic conditions inside mitochondria
Alexander M, van der Bliek +2 more
openaire +2 more sources
Mitochondrial Fission, Fusion, and Stress [PDF]
Science, 2012 Mitochondrial Dynamics Mitochondria—the powerhouses of the cell—are autonomous organelles with their own genomes. Within cells, mitochondria are remarkably dynamic, continually moving around the cytoplasm and undergoing fusion and fission reactions. Youle and van der Bliek (p. 1062 )
Richard J, Youle +1 more
openaire +2 more sources
Cells, 2023 Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular calcium
Pierce Colpman +2 more
doaj +1 more source
Toxics, 2021 Dichlorodiphenyldichloroethylene (DDE), the primary persistent metabolite of dichlorodiphenyltrichloroethane (DDT), has toxic effects on cells, but its dose-dependent impact on mitochondrial proteins involved in mitochondrial fusion and fission processes
Mario Alberto Burgos Aceves +7 more
doaj +1 more source
Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance. [PDF]
PLoS ONE, 2013 Accumulation of mitochondrial DNA (mtDNA) mutations has been implicated in a wide range of human pathologies, including neurodegenerative diseases, sarcopenia, and the aging process itself.
Zhi Yang Tam +3 more
doaj +1 more source
Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer
Breast Cancer Research, 2020 Background Mitochondrial dynamics underlies malignant transformation, cancer progression, and response to treatment. Current research presents conflicting evidence for functions of mitochondrial fission and fusion in tumor progression.
Brock A. Humphries +21 more
doaj +1 more source
TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. [PDF]
PLoS ONE, 2012 Mitochondria are dynamic organelles that change in response to extracellular stimuli. These changes are essential for normal mitochondrial/cellular function and are controlled by a tight balance between two antagonistic pathways that promote fusion and ...
Hironori Takamura +8 more
doaj +1 more source
Metabolic consequences of neuronal mitochondrial fission ablation [PDF]
, 2016 Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
core +1 more source