Results 51 to 60 of about 156,551 (297)
Mitochondrial division, fusion and degradation
The Journal of Biochemistry, 2019 Abstract The mitochondrion is an essential organelle for a wide range of cellular processes, including energy production, metabolism, signal transduction and cell death. To execute these functions, mitochondria regulate their size, number, morphology and distribution in cells via mitochondrial division and fusion.
Daisuke, Murata +3 more
openaire +3 more sources
Early steps in mitochondrial protein import [PDF]
, 1990 The process of insertion of precursor proteins into mitochondrial membranes was investigated using a hybrid protein (pSc1-c) that contains dual targeting information and, at the same time, membrane insertion activity.
Stuart, Rosemary A. +2 more
core +1 more source
Targeting mitochondria by mitochondrial fusion, mitochondria-specific peptides and nanotechnology
, 2013 This thesis was focused on mitochondria as an intracellular target for drug delivery by the reason that mitochondria are becoming of increasing interest in pharmaceutical and medical research due to their contribution to several diseases (Chapter 1).
Heller, Anne Sabine
core +1 more source
Fusion of secretory vesicles isolated from rat liver [PDF]
, 1978 Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
Dahl, Gerhard +2 more
core +1 more source
Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration
Frontiers in Molecular Neuroscience, 2019 Mitochondrial dysfunction is a recognized hallmark of neurodegenerative diseases and abnormal mitochondrial fusion-fission dynamics have been implicated in the pathogenesis of neurodegenerative disorders. This study characterizes the effects of metabolic
Darren O’Hara +4 more
doaj +1 more source
Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review
World Journal of Surgical Oncology, 2022 Background Mitochondria play critical roles in cellular physiological activity as cellular organelles. Under extracellular stimulation, mitochondria undergo constant fusion and fission to meet different cellular demands. Mitochondrial dynamics, which are
Jixiang Xing +5 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Drp1 ablation in the adult mouse forebrain [PDF]
, 2014 Due to their high energy demand, their highly polarized nature and the sheer length of their processes, neurons - more than any other cell type - depend on a well-balanced dynamic mitochondrial network.
Oettinghaus, Bjorn
core +1 more source
Mitochondrial Fusion Machinery Specifically Involved in Energy Deprivation-Induced Autophagy
Frontiers in Cell and Developmental Biology, 2020 Mitochondria are highly dynamic organelles, which can form a network in cells through fusion, fission, and tubulation. Its morphology is closely related to the function of mitochondria. The damaged mitochondria can be removed by mitophagy.
Choufei Wu +15 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source