Results 51 to 60 of about 256,048 (301)
Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus
Neurology Research International, 2015 Brain is predominantly susceptible to oxidative stress and mitochondrial dysfunction during hypobaric hypoxia, and therefore undergoes neurodegeneration due to energy crisis.
Khushbu Jain +3 more
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Regulation of Mitochondrial Dynamics and Neurodegenerative Diseases [PDF]
, 2011 Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent
Fujimura, Atsushi +6 more
core +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003 Mitochondrial fusion has been observed in a great variety of organisms from yeast to man. It serves to mix and unify the mitochondrial compartment and plays roles in cellular aging, cell development, energy dissipation and mitochondrial DNA inheritance. Large GTPases in the mitochondrial outer membrane, termed Fzo or mitofusins, have been identified as
openaire +2 more sources
Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]
, 2015 Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Anderson, G +14 more
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Bok regulates mitochondrial fusion and morphology [PDF]
Cell Death & Differentiation, 2019 Bok (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family that governs the intrinsic apoptosis pathway, but the cellular role that Bok plays is controversial. Remarkably, endogenous Bok is constitutively bound to inositol 1,4,5-trisphosphate receptors (IP3Rs) and is stabilized by this interaction. Here we report that despite the strong
Jacqualyn J. Schulman +7 more
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The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury
Biomolecules, 2021 Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study the temporal dynamics of mitochondrial fusion and fission, we observed the alteration of mitochondrial ...
Yunsi Zheng, Anqi Luo, Xiaoquan Liu
doaj +1 more source
Mitochondrial fission/fusion and cardiomyopathy [PDF]
Current Opinion in Genetics & Development, 2016 Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist.
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Role of mitochondrial fusion in doxorubicin-induced cardiotoxicity [PDF]
Jichu yixue yu linchuangAdriamycin is a widely used anti-tumor drug. Targeting mitochondrial fusion proteins/mitofusion 1/2(MFN1/2) and nuclear factor-erythroid 2-related factor 2(NRF2) can up-regulate the expression of mitochondrial fusion protein through PKCε/Stat3/MFN2 ...
WANG Yuqi, WANG Xinyu, LUO Haowen, LU Zhaoxin, ZHAO Yiwei, CHANG Pan
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Mitochondrial protein import [PDF]
, 1987 The precursor of F0-ATPase subunit 9 was bound to mitochondria in the absence of a mitochondrial membrane potential (delta psi). Binding was mediated by a protease-sensitive component on the mitochondrial surface.
Harmey, Matthew A. +3 more
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The essential role of mitochondrial dynamics in antiviral immunity. [PDF]
, 2018 Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun +3 more
core +2 more sources