Results 71 to 80 of about 1,253,804 (210)
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
BMC Biology, 2010 Background Mitochondria are highly dynamic organelles whose morphology and position within the cell is tightly coupled to metabolic function. There is a limited list of essential proteins that regulate mitochondrial morphology and the mechanisms that ...
Bilodeau Patricia +9 more
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Protein & Cell, 2017 Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson’s disease, dystonia, and epilepsy.
Crystal A. Lee, Lih-Shen Chin, Lian Li
doaj +1 more source
A study of mitochondrial biogenesis in the rodent nervous system [PDF]
, 2015 This thesis investigates the process of mitochondrial biogenesis in the rodent CNS in the context of neuroinflammatory and neurodegenerative disease. There is mounting evidence of mitochondrial damage in neuroinflammation but very little is known about ...
Desai, R
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The mitochondrial receptor complex [PDF]
, 1993 The receptor complex in the mitochondrial outer membrane, which consists of at least seven different proteins, is responsible for the recognition and translocation of cytosolically synthesized preproteins.
Klei, Ida J. van der; id_orcid +12 more
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Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Structure and function of bacterial dynamin-like proteins [PDF]
, 2012 Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Workshop at Data and Planning Center of NIFS in 2003 "Assesment of Fusion R&D" - The Critical Issues of Demonstration Fusion Reactor - [PDF]
, 2004 実証炉を構想しそれに至る課題を整理することは、核融合研究開発の現状を評価するうえで最も適切な作業のひとつと考えた。磁場閉じ込めと慣性閉じ込め核融合に共通な課題は経済性の改善である。また、磁場閉じ込めではトカマクもヘリカルも将来性のあるダイバータの開発は共通である。 経済性に関しては先進トカマクや高速点火方式のレーザ慣性核融合の提案が出てきている。さらにダイバータに関しては可動型や外置き型の研究が進められている。これらの要約は添付した。In order to asses the fusion ...
TAZIMA, Teruhiko +2 more
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