Mitochondrial fusion is required for regulation of mitochondrial DNA replication. [PDF]
PLoS Genetics, 2019 Mitochondrial dynamics is an essential physiological process controlling mitochondrial content mixing and mobility to ensure proper function and localization of mitochondria at intracellular sites of high-energy demand.
Eduardo Silva Ramos +12 more
doaj +2 more sources
Deceleration of fusion–fission cycles improves mitochondrial quality control during aging [PDF]
, 2012 Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Michael Meyer-Hermann +18 more
core +2 more sources
Emergence of the mitochondrial reticulum from fission and fusion dynamics [PDF]
, 2012 Mitochondria form a dynamic tubular reticulum within eukaryotic cells. Currently, quantitative understanding of its morphological characteristics is largely absent, despite major progress in deciphering the molecular fission and fusion machineries ...
Michael Meyer-Hermann +13 more
core +1 more source
Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion [PDF]
, 2009 Two dynamin-related protein (DRP) families are essential for fusion of the outer and inner mitochondrial membranes, Fzo1 (yeast)/Mfn1/Mfn2 (mammals) and Mgm1 (yeast)/Opa1 (mammals), respectively.
Stahlberg, Henning +11 more
core +2 more sources
Mitochondrial DNA mutations provoke dominant inhibition of mitochondrial inner membrane fusion. [PDF]
PLoS ONE, 2012 Mitochondria are highly dynamic organelles that continuously move, fuse and divide. Mitochondrial dynamics modulate overall mitochondrial morphology and are essential for the proper function, maintenance and transmission of mitochondria and mitochondrial
Cécile Sauvanet +6 more
doaj +1 more source
Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]
, 2014 Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core +1 more source
Comparative Untargeted Metabolomic Profiling of Induced Mitochondrial Fusion in Pancreatic Cancer
Metabolites, 2021 Mitochondria are dynamic organelles that constantly alter their shape through the recruitment of specialized proteins, like mitofusin-2 (Mfn2) and dynamin-related protein 1 (Drp1).
Nicholas D. Nguyen +8 more
doaj +1 more source
Targeting mitochondria by mitochondrial fusion, mitochondria-specific peptides and nanotechnology [PDF]
, 2013 This thesis was focused on mitochondria as an intracellular target for drug delivery by the reason that mitochondria are becoming of increasing interest in pharmaceutical and medical research due to their contribution to several diseases (Chapter 1).
Heller, Anne Sabine
core +1 more source
Neurodegenerative stress related mitochondrial proteostasis [PDF]
, 2015 1.1 Background: Mitochondria are the main site of energy production in most cells. Furthermore, they are involved in a multitude of other essential cellular processes, such as regulating the cellular calcium pool, lipid metabolism and programmed cell ...
Fang, Lei
core +1 more source
Respiratory chain complexes in dynamic mitochondria display a patchy distribution in life cells [PDF]
, 2010 Background: Mitochondria, the main suppliers of cellular energy, are dynamic organelles that fuse and divide frequently. Constraining these processes impairs mitochondrial is closely linked to certain neurodegenerative diseases.
Strecker, V. +23 more
core +2 more sources