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Mitochondrial Fission, Fusion, and Stress [PDF]
Science, 2012 Mitochondrial Dynamics Mitochondria—the powerhouses of the cell—are autonomous organelles with their own genomes. Within cells, mitochondria are remarkably dynamic, continually moving around the cytoplasm and undergoing fusion and fission reactions. Youle and van der Bliek (p. 1062 )
Richard J, Youle +1 more
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Mitochondrial fusion is required for regulation of mitochondrial DNA replication.
PLoS Genetics, 2019 Mitochondrial dynamics is an essential physiological process controlling mitochondrial content mixing and mobility to ensure proper function and localization of mitochondria at intracellular sites of high-energy demand.
Eduardo Silva Ramos +12 more
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Mitochondrial Fusion and Fission in Mammals [PDF]
Annual Review of Cell and Developmental Biology, 2006 Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial fragmentation, and unbalanced fusion leads to mitochondrial elongation.
Doris Chan
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Mitochondrial Fusion Proteins and Human Diseases [PDF]
Neurology Research International, 2013 Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell.
Michela Ranieri +7 more
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Mitochondrial fusion, fission, and mitochondrial toxicity [PDF]
Toxicology, 2017 Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and function, and are increasingly ...
Joel N, Meyer +2 more
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Mitochondrial fission and fusion [PDF]
Essays in Biochemistry, 2010 Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the ...
Iain, Scott, Richard J, Youle
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Fusion activators enhance mitochondrial function
Mitochondrial Communications, 2023 Mitochondria are dynamic organelles that regulate cycles of fusion and fusion to tune their energy output and to respond to cellular damage.1Under homeostatic conditions,mitochondrial fusionand fission are kept in balance to maintain proper mitochondrial morphology and function.
William M. Rosencrans, David C. Chan
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Mitochondrial dynamics: quantifying mitochondrial fusion in vitro [PDF]
BMC Biology, 2010 Mitochondrial fusion is an essential process for preserving the integrity and stability of mitochondrial DNA; however, regulation of this process remains largely mysterious. In this issue of BMC Biology, Schauss and colleagues describe a simple, reliable, and robust novel assay that allows fusion of mammalian mitochondria to be quantified in vitro.
Jourdain Alexis, Martinou Jean-Claude
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Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. [PDF]
PLoS ONE, 2011 Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change.
Pinwei Huang +2 more
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MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion
EMBO Reports, 2023 Fusion of the outer mitochondrial membrane (OMM) is regulated by mitofusin 1 (MFN1) and 2 (MFN2), yet the differential contribution of each of these proteins is less understood.
Andres Goldman +5 more
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