Results 111 to 120 of about 49,263 (303)

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus

Neurology Research International, 2015
Brain is predominantly susceptible to oxidative stress and mitochondrial dysfunction during hypobaric hypoxia, and therefore undergoes neurodegeneration due to energy crisis.
Khushbu Jain, Dipti Prasad, Shashi Bala Singh, Ekta Kohli   +3 more
doaj   +1 more source

Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia

Brain Sciences, 2020
Mitochondrial morphology, distribution and function are maintained by the opposing forces of mitochondrial fission and fusion, the perturbation of which gives rise to several neurodegenerative disorders.
Philippa C. Fowler, Dwayne J. Byrne, Craig Blackstone, Niamh C. O'Sullivan   +3 more
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

DRP3 and ELM1 are required for mitochondrial fission in the liverwort Marchantia polymorpha

Scientific Reports, 2017
Mitochondria increase in number by the fission of existing mitochondria. Mitochondrial fission is needed to provide mitochondria to daughter cells during cell division.
Nagisa Nagaoka, Akihiro Yamashita, Rina Kurisu, Yuta Watari, Fumiko Ishizuna, Nobuhissro Tsutsumi, Kimitsune Ishizaki, Takayuki Kohchi, Shin-ichi Arimura   +8 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

A role for septin 2 in Drp1-mediated mitochondrial fission

, 2016
Mitochondria are essential eukaryotic organelles often forming intricate networks. The overall network morphology is determined by mitochondrial fusion and fission.
Tham, To Nam, Stevens, Julia K., To Nam Tham,, Lagache, Thibault, Audrey Salles, Alessandro Pagliuso, Thibault Lagache, Stevens, Julia K, Persson, Roger, Roger Persson, Fabrizia Stavru, Stavru, Fabrizia, Pagliuso, Alessandro, Olivo-Marin, Jean-Christophe, Pascale Cossart, Salles, Audrey, Anne Spang, Spang, Anne, Stéphane Oddos, Cossart, Pascale, Julia K Stevens, Olivo‐marin, Jean‐christophe, Jean‐Christophe Olivo‐Marin, To Nam Tham, Oddos, Stéphane   +24 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

eLife, 2015
While the dynamin GTPase Drp1 plays a critical role during mitochondrial fission, mechanisms controlling its recruitment to fission sites are unclear. A current assumption is that cytosolic Drp1 is recruited directly to fission sites immediately prior to
Wei-ke Ji, Anna L Hatch, Ronald A Merrill, Stefan Strack, Henry N Higgs   +4 more
doaj   +1 more source