Results 101 to 110 of about 49,263 (303)

Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. [PDF]

PLoS ONE, 2012
Evasion of apoptosis is implicated in almost all aspects of cancer progression, as well as treatment resistance. In this study, resistance to apoptosis was identified in tumorigenic lung epithelial (A549) cells as a consequence of defects in ...
Kelly Jean Thomas, Marty R Jacobson
doaj   +1 more source

Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure

, 2022
International audienceMitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein that is dispensable for mitochondrial division ...
Kohlhaas, Michael, Wai, Timothy, Gianetto, Quentin Giai, Chaze, Thibault, Moya-Nilges, Maryse, Maack, Christoph, Kornobis, Etienne, Vimont, Elodie, Matondo, Mariette, Donnarumma, Erminia   +9 more
core   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Efeitos da hiperglicemia crônica e seus metabólitos, metilglioxal e produtos terminais de glicação, na fisiologia e dinâmica mitocondrial no sistema nervoso central [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.O diabetes mellitus (DM) é uma doença metabólica comum, caracterizada por um estado de hiperglicemia
Glaser, Viviane
core  

Multi-patterned dynamics of mitochondrial fission and fusion in a living cell.

, 2012
Mitochondria are highly-dynamic organelles, but it is challenging to monitor quantitatively their dynamics in a living cell. Here we developed a novel approach to determine the global occurrence of mitochondrial fission and fusion events in living human ...
Lu, Shouqin, Chen, Ming, Shan Sicong, Quan Chen (163802), Zhang, Yan, Chen, Quan, Chuanmao Zhang, Chunsun Jiang (163786), Xiao, Weiming, Chen Juan, Long, Mian, Shan, Sicong, Shiqi Wang, Chen M, Lü Shouqin, Zhang, Chuanmao, Juan Chen, Chen Ming, Chen Quan, Yan Zhang, Mian Long, Weiming Xiao (163778), Ming Chen, Sicong Shan, 王世骐, Jiang, Chunsun, 吕守芹, Wang, SQ, 龙勉, Zhang Yan, 陈娟, 单思聪, Wang, Shiqi, Ming Chen (115604), Zhang CM, Wang Shiqi, Xiao WM, Shouqin Lü, Mian Long (163806), Yan Zhang (8098), Jiang Chunsun, Chunsun Jiang, Quan Chen, Zhang Chuanmao, Weiming Xiao, Juan Chen (61123), Jiang CS, Sicong Shan (163783), Long Mian, Chuanmao Zhang (163797), Shiqi Wang (163773), Chinese Acad Sci, Natl Micrograv Lab, Key Lab Micrograv, Beijing, Peoples R China., Shouqin Lü (163792), Xiao Weiming, 章燕, Chen, Juan   +55 more
core   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Mitochondrial Fission: Rings around the Organelle [PDF]

Current Biology, 2013
Mitochondria form a dynamic network in which organelles fuse or divide in response to metabolic changes or cellular stress. New work shows that mitochondria do not divide in isolation from other cellular structures. Rather, they carry out this process in partnership with the endoplasmic reticulum and actin filaments.
openaire   +2 more sources

Alternative oxidase dependent respiration leads to an increased mitochondrial content in two long-lived mutants of the aging model Podospora anserina

, 2011
The retrograde response constitutes an important signalling pathway from mitochondria to the nucleus which induces several genes to allow compensation of mitochondrial impairments.
Koen Houthoofd, Jacques R. Vanfleteren, Werner, Alexandra, Christian Q. Scheckhuber, De Vreese, Annemie, Scheckhuber Christian Q., Andrea C. Weil, Heinz D. Osiewacz, Jacques R Vanfleteren, Osiewacz, Heinz D., Scheckhuber, Christian Quintus, Christian Q Scheckhuber, De Vreese Annemie, Houthoofd Koen, Vanfleteren Jacques R., Vanfleteren, Jacques R., Weil Andrea C., Andrea C Weil, Werner Alexandra, Heinz D Osiewacz, Houthoofd, Koen, Osiewacz Heinz D., Alexandra Werner, Annemie De Vreese, Weil, Andrea C.   +24 more
core   +1 more source

Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy [PDF]

, 2010
Background: Up to the 1950s, there was an ongoing debate about the diversity of hereditary optic neuropathies, in particular as to whether all inherited optic atrophies can be ascribed to Leber's hereditary optic neuropathy (LHON) or represent different ...
Alexander Christiane, Schimpf Simone, Bernd Wissinger, Zrenner, Eberhart, Alavi, M.V., Schimpf, Simone, Auburger Georg, Zrenner, E., Zrenner Eberhart, Schimpf, S., Alavi-Khorassani Moghadam, Marcel Victor, Auburger, Georg, Leo-Kottler, Beate, Marcel V Alavi, Wissinger, Bernd, Christiane Alexander, Nico Fuhrmann, Wissinger, B., Fuhrmann Nico, Beate Leo-Kottler, Alexander, Christiane, Kamenisch, York, Fuhrmann, Nico, Kamenisch, Y., Wissinger Bernd, Auburger, G., Simone Schimpf, Eberhart Zrenner, Georg Auburger, Kamenisch York, York Kamenisch, Alexander, C., Leo-Kottler, B., Leo-Kottler Beate, Alavi Marcel V, Fuhrmann, N.   +35 more
core   +1 more source