Results 41 to 50 of about 184,138 (308)

Dynamics of Mitochondrial Transport in Axons [PDF]

Frontiers in Cellular Neuroscience, 2016
The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only
Niescier, Robert F., Kwak, Sang Kyu, Joo, Se Hun, Chang, Karen T., Min, Kyung-Tai   +4 more
openaire   +4 more sources

SnapShot: Mitochondrial Dynamics

Cell, 2011
Mitochondria are tubular, highly dynamic organelles that continuously fuse and divide in a regulated manner. A balance of fusion and division controls mitochondrial morphol-ogy; imbalanced dynamics leads to altered morphology, which is associated with a variety of pathological conditions.
Tamura, Yasushi, Itoh, Kie, Sesaki, Hiromi   +2 more
openaire   +2 more sources

A morphological view on mitochondrial protein targeting [PDF]

, 1994
Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ida J. van der Klei, Walter Neupert, Neupert, Walter, Marten Veenhuis, Veenhuis, Marten, Klei, Ida J. van der   +5 more
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Mitochondrial Dynamics Decrease Prior to Axon Degeneration Induced by Vincristine and are Partially Rescued by Overexpressed cytNmnat1.

Frontiers in Cellular Neuroscience, 2016
Axon degeneration is a prominent feature of various neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, and is often characterized by aberrant mitochondrial dynamics.
Gregory Berbusse, Laken Woods, Bhupinder P.S. Vohra, Kari Naylor   +3 more
doaj   +1 more source

Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes.

Acta medica Okayama, 2016
The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS ...
Wada, Jun, Nakatsuka, Atsuko
openaire   +3 more sources

Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing

Biology Open, 2020
Mitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is ...
Susana Ponte, Lara Carvalho, Maria Gagliardi, Isabel Campos, Paulo J. Oliveira, António Jacinto   +5 more
doaj   +1 more source

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease. [PDF]

, 2013
Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of ...
Adame, Anthony, Mueller, Sarina, Bender Andreas, Sarina Mueller, Koob Andrew O., Elstner Matthias, Elstner, Matthias, Desplats, Paula, Mante, Michael, Eliezer Masliah, Desplats Paula, Mueller Sarina, Spencer, Brian, Matthias Elstner, Thomas Klopstock, Masliah, Eliezer, Koob, Andrew O., Andreas Bender, Bender, Andreas, Masliah Eliezer, Anthony Adame, Klopstock Thomas, Rockenstein, Edward, Laub Christoph, Rockenstein Edward, Pham Emily, Brian Spencer, Mante Michael, Michael Mante, Klopstock, Thomas, Christoph Laub, Spencer Brian, Adame Anthony, Andrew O Koob, Paula Desplats, Emily Pham, Laub, Christoph, Pham, Emily, Edward Rockenstein   +38 more
core   +1 more source

Emergence of the mitochondrial reticulum from fission and fusion dynamics

, 2012
Mitochondria form a dynamic tubular reticulum within eukaryotic cells. Currently, quantitative understanding of its morphological characteristics is largely absent, despite major progress in deciphering the molecular fission and fusion machineries ...
Michael Meyer-Hermann, Michael Meyer-Hermann (124166), Andreas S. Reichert (124162), Sukhorukov, Valerii M., Daniel Dikov (124160), Valerii M. Sukhorukov (124158), Reichert, Andreas, Valerii M. Sukhorukov, Dikov, Daniel, Andreas S. Reichert, Meyer-Hermann, Michael (Prof. Dr.), Valerii M Sukhorukov, Daniel Dikov, Andreas S Reichert   +13 more
core   +1 more source

Metabolic consequences of neuronal mitochondrial fission ablation [PDF]

, 2016
Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
core   +1 more source

Molecular markers from the mitochondrial genome of arbuscular mycorrhizal fungi (Glomeromycota) : evolutionary dynamics and application [PDF]

, 2010
The arbuscular mycorrhizal fungi (AMF) are obligate biotrophic symbionts with a key role in ecosystem functioning by their main contribution to plant mineral nutrient uptake. A fragment of the mitochondrial large subunit gene of ribosomal RNA (mtLSU) has
Thiéry, Odile
core   +1 more source