Results 31 to 40 of about 184,138 (308)

Neurodegenerative stress related mitochondrial proteostasis [PDF]

, 2015
1.1 Background: Mitochondria are the main site of energy production in most cells. Furthermore, they are involved in a multitude of other essential cellular processes, such as regulating the cellular calcium pool, lipid metabolism and programmed cell ...
Fang, Lei
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Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells

Frontiers in Cell and Developmental Biology, 2020
Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration due to their potential for self-renewal, multilineage differentiation, and immune modulation.
Lin Ren, Lin Ren, Lin Ren, Xiaodan Chen, Xiaodan Chen, Xiaodan Chen, Xiaobing Chen, Xiaobing Chen, Xiaobing Chen, Jiayan Li, Jiayan Li, Jiayan Li, Bin Cheng, Bin Cheng, Bin Cheng, Juan Xia, Juan Xia, Juan Xia   +17 more
doaj   +1 more source

Current Understanding of the Pivotal Role of Mitochondrial Dynamics in Cardiovascular Diseases and Senescence

Frontiers in Cardiovascular Medicine, 2022
The heart is dependent on ATP production in mitochondria, which is closely associated with cardiovascular disease because of the oxidative stress produced by mitochondria. Mitochondria are highly dynamic organelles that constantly change their morphology
Yoshihiro Uchikado, Yoshiyuki Ikeda, Mitsuru Ohishi   +2 more
doaj   +1 more source

Mitochondrial Dynamics in Tachycardiomyopathy [PDF]

Cellular Physiology and Biochemistry, 2019
Tachycardiomyopathy (TCM) is a largely reversible form of non-ischemic heart failure. The underlying mechanism are, however, still today poorly understood. Recent data indicate distinct changes in mitochondrial distribution in these patients, compared to other non-ischemic cardiomyopathies.This study investigated underlying mechanisms in mitochondrial ...
David Heinzmann, Karin Klingel, Karin Müller, Jörg Kumbrink, Thomas Kirchner, Jürgen Schreieck, Meinrad Gawaz, Peter Seizer   +7 more
openaire   +3 more sources

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]

, 2015
Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Jan-Willem Taanman, Shamima Rahman, Laura D. Osellame, Gilmour, Kimberley, Glenn Anderson, Jacques, Thomas S, Sophie Hambleton, Cale, Catherine, Osellame, Laura, Plagnol, Vincent, Chalasani, A, Annapurna Chalasani, Gilmour, KC, Hambleton, Sophie, Wedatilake, Yehani, Gilmour, Kimberley C, Duchen, Michael R, Osellame, LD, Taanman, Jan-Willem, Jacques, S, Vincent Plagnol, Plagnol, V, Rahman, S, Yehani Wedatilake, Michael R. Duchen, Shahni, Rojeen, Qasim, Waseem, Thomas S. Jacques, Catherine M. Cale, Duchen, Michael, Cale, Catherine M, Waseem Qasim, Anderson, Glenn, Wadatilake, Y, Cale, CM, Rahman, Shamima, Osellame, Laura D, Taanman, JW, Chan, E, Jacques, Thomas, Anderson, G, Rojeen Shahni, Chalasani, Annapurna, Kimberly C. Gilmour, Qasim, W, Emma Chan, Hambleton, S, Duchen, MR, Shahni, R, Chan, Emma   +49 more
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Mitochondrial dynamics: quantifying mitochondrial fusion in vitro [PDF]

BMC Biology, 2010
Mitochondrial fusion is an essential process for preserving the integrity and stability of mitochondrial DNA; however, regulation of this process remains largely mysterious. In this issue of BMC Biology, Schauss and colleagues describe a simple, reliable, and robust novel assay that allows fusion of mammalian mitochondria to be quantified in vitro.
Jourdain Alexis, Martinou Jean-Claude
openaire   +6 more sources

Rutin inhibits DRP1-mediated mitochondrial fission and prevents ethanol-induced hepatotoxicity in HepG2 cells and zebrafish

Animal Cells and Systems, 2021
Excessive alcohol consumption causes the cellular and tissue damage. The toxic metabolites of ethanol are harmful to multiple organ systems, such as the central nervous system, skeletal muscles, and liver, and cause alcohol-induced diseases like cancer ...
Youngsook Choi, Heymin Seo, Mina Cho, Joohee Kim, Hak Suk Chung, Icksoo Lee, Min Jung Kim   +6 more
doaj   +1 more source

Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia

Frontiers in Cell and Developmental Biology, 2021
BackgroundCancer-associated cachexia (CAC) is a syndrome characterized by skeletal muscle atrophy, and the underlying mechanisms are still unclear. Recent research studies have shed light on a noteworthy link between mitochondrial dynamics and muscle ...
Xiangyu Mao, Yihua Gu, Xiangyu Sui, Lei Shen, Jun Han, Haiyu Wang, Qiulei Xi, Qiulin Zhuang, Qingyang Meng, Guohao Wu   +9 more
doaj   +1 more source

Mitochondrial dynamics and metastasis [PDF]

Cellular and Molecular Life Sciences, 2018
Changes in cellular metabolism are now a recognized hallmark of cancer. Although this process is ripe with therapeutic potential in the clinic, its complexity and extraordinary plasticity have systematically defied dogmas and oversimplifications. Perhaps, best exemplifying this intricacy is the role of mitochondria in cancer, which in just a few years ...
openaire   +2 more sources

Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]

, 2014
Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core   +1 more source