Results 11 to 20 of about 170,782 (263)
Mitochondrial dynamics and mitochondrial quality control
Redox Biology, 2015 Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis
Hong-Min Ni +2 more
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Mitochondrial dynamics and apoptosis [PDF]
Genes & Development, 2008 In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control.
Der-Fen, Suen +2 more
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Mitochondrial dynamics in neurodegeneration [PDF]
Trends in Cell Biology, 2013 It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it became clear that these dynamic ...
Itoh, Kie +3 more
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Sphingolipids and Mitochondrial Dynamic [PDF]
Cells, 2020 For decades, sphingolipids have been related to several biological functions such as immune system regulation, cell survival, and proliferation. Recently, it has been reported that sphingolipids could be biomarkers in cancer and in other human disorders such as metabolic diseases.
Lais Brigliadori Fugio +2 more
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Disturbance of Mitochondrial Dynamics and Mitochondrial Therapies in Atherosclerosis [PDF]
Life, 2021 Mitochondrial dysfunction is associated with a wide range of chronic human disorders, including atherosclerosis and diabetes mellitus. Mitochondria are dynamic organelles that undergo constant turnover in living cells. Through the processes of mitochondrial fission and fusion, a functional population of mitochondria is maintained, that responds to the ...
Alexander M. Markin +7 more
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Mitochondrial dynamics and cancer [PDF]
Tumor Biology, 2017 Cancer is among the leading causes of death worldwide, and the number of new cases continues to rise. Despite recent advances in diagnosis and therapeutic strategies, millions of cancer-related deaths occur, indicating the need for better therapies and diagnostic strategies.
Paola Maycotte +5 more
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Mitochondrial Dynamics in Diabetes [PDF]
Antioxidants & Redox Signaling, 2011 Mitochondria are at the center of cellular energy metabolism and regulate cell life and death. The cell biological aspect of mitochondria, especially mitochondrial dynamics, has drawn much attention through implications in human pathology, including neurological disorders and metabolic diseases. Mitochondrial fission and fusion are
Yisang, Yoon +3 more
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Mitochondrial dynamics in astrocytes [PDF]
Biochemical Society Transactions, 2014 Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca2+) levels in response to synaptic activity. Astrocyte Ca2+ elevations can trigger the release of neuroactive substances that can modulate synaptic transmission and plasticity, hence promoting bidirectional communication with neurons.
Stephen, TL +2 more
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Mitochondrial Dynamics in Tachycardiomyopathy [PDF]
Cellular Physiology and Biochemistry, 2019 Tachycardiomyopathy (TCM) is a largely reversible form of non-ischemic heart failure. The underlying mechanism are, however, still today poorly understood. Recent data indicate distinct changes in mitochondrial distribution in these patients, compared to other non-ischemic cardiomyopathies.This study investigated underlying mechanisms in mitochondrial ...
David Heinzmann +7 more
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Frontiers in Cardiovascular Medicine, 2022 The heart is dependent on ATP production in mitochondria, which is closely associated with cardiovascular disease because of the oxidative stress produced by mitochondria. Mitochondria are highly dynamic organelles that constantly change their morphology
Yoshihiro Uchikado +2 more
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