Results 21 to 30 of about 170,782 (263)
Frontiers in Cell and Developmental Biology, 2021 BackgroundCancer-associated cachexia (CAC) is a syndrome characterized by skeletal muscle atrophy, and the underlying mechanisms are still unclear. Recent research studies have shed light on a noteworthy link between mitochondrial dynamics and muscle ...
Xiangyu Mao +9 more
doaj +1 more source
Mitochondrial dynamics: quantifying mitochondrial fusion in vitro [PDF]
BMC Biology, 2010 Mitochondrial fusion is an essential process for preserving the integrity and stability of mitochondrial DNA; however, regulation of this process remains largely mysterious. In this issue of BMC Biology, Schauss and colleagues describe a simple, reliable, and robust novel assay that allows fusion of mammalian mitochondria to be quantified in vitro.
Jourdain Alexis, Martinou Jean-Claude
openaire +6 more sources
Mitochondrial dynamics and metastasis [PDF]
Cellular and Molecular Life Sciences, 2018 Changes in cellular metabolism are now a recognized hallmark of cancer. Although this process is ripe with therapeutic potential in the clinic, its complexity and extraordinary plasticity have systematically defied dogmas and oversimplifications. Perhaps, best exemplifying this intricacy is the role of mitochondria in cancer, which in just a few years ...
openaire +2 more sources
Animal Cells and Systems, 2021 Excessive alcohol consumption causes the cellular and tissue damage. The toxic metabolites of ethanol are harmful to multiple organ systems, such as the central nervous system, skeletal muscles, and liver, and cause alcohol-induced diseases like cancer ...
Youngsook Choi +6 more
doaj +1 more source
Dynamics of Mitochondrial Transport in Axons [PDF]
Frontiers in Cellular Neuroscience, 2016 The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only
Niescier, Robert F. +4 more
openaire +4 more sources
Frontiers in Cellular Neuroscience, 2016 Axon degeneration is a prominent feature of various neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, and is often characterized by aberrant mitochondrial dynamics.
Gregory Berbusse +3 more
doaj +1 more source
SnapShot: Mitochondrial Dynamics
Cell, 2011 Mitochondria are tubular, highly dynamic organelles that continuously fuse and divide in a regulated manner. A balance of fusion and division controls mitochondrial morphol-ogy; imbalanced dynamics leads to altered morphology, which is associated with a variety of pathological conditions.
Tamura, Yasushi +2 more
openaire +2 more sources
Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes.
Acta medica Okayama, 2016 The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS ...
Wada, Jun, Nakatsuka, Atsuko
openaire +3 more sources
Mitochondrial dynamics and cancer
Seminars in Cancer Biology, 2009 Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If the last years have witnessed major discoveries in the characterization of the fission and fusion machineries, little is known about the physiological role of mitochondrial dynamics.
Grandemange, Stéphanie +2 more
openaire +6 more sources
Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
Biology Open, 2020 Mitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is ...
Susana Ponte +5 more
doaj +1 more source