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Sphingolipids and Mitochondrial Dynamic [PDF]
Cells, 2020 For decades, sphingolipids have been related to several biological functions such as immune system regulation, cell survival, and proliferation. Recently, it has been reported that sphingolipids could be biomarkers in cancer and in other human disorders such as metabolic diseases.
Lais Brigliadori Fugio +2 more
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Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders
Membranes, 2022 Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission
Mode Al Ojaimi +2 more
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Disturbance of Mitochondrial Dynamics and Mitochondrial Therapies in Atherosclerosis [PDF]
Life, 2021 Mitochondrial dysfunction is associated with a wide range of chronic human disorders, including atherosclerosis and diabetes mellitus. Mitochondria are dynamic organelles that undergo constant turnover in living cells. Through the processes of mitochondrial fission and fusion, a functional population of mitochondria is maintained, that responds to the ...
Alexander M. Markin +7 more
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Mitochondrial dynamics and cancer [PDF]
Tumor Biology, 2017 Cancer is among the leading causes of death worldwide, and the number of new cases continues to rise. Despite recent advances in diagnosis and therapeutic strategies, millions of cancer-related deaths occur, indicating the need for better therapies and diagnostic strategies.
Paola Maycotte +5 more
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Frontiers in Neuroscience, 2021 In neurodegenerative diseases, neurodegeneration has been related to several mitochondrial dynamics imbalances such as excessive fragmentation of mitochondria, impaired mitophagy, and blocked mitochondria mitochondrial transport in axons.
Danying Yang +16 more
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Frontiers in Cell and Developmental Biology, 2020 Cardiac ischemia-reperfusion (I/R) injury is associated with mitochondrial dysfunction. Recent studies have reported that mitochondrial function is determined by mitochondrial dynamics.
Yuanyan Deng +5 more
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Frontiers in Applied Mathematics and Statistics, 2023 There is growing evidence that mitochondrial dynamics play a role in mitochondrial function quality control. Recent studies have discovered that physical activity can aid in maintaining a healthy mitochondrial population and may even counteract the ...
Ángel J. Zamora-Ramírez +1 more
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Mitochondrial Dynamics in Diabetes [PDF]
Antioxidants & Redox Signaling, 2011 Mitochondria are at the center of cellular energy metabolism and regulate cell life and death. The cell biological aspect of mitochondria, especially mitochondrial dynamics, has drawn much attention through implications in human pathology, including neurological disorders and metabolic diseases. Mitochondrial fission and fusion are
Yisang, Yoon +3 more
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Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets
Frontiers in Neuroscience, 2022 Mitochondria are the powerhouse of the cells. Under physiological conditions, mitochondrial fission and fusion maintain a dynamic equilibrium in the cytoplasm, which is referred to as mitochondrial dynamics.
Tianyuan Zou +29 more
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Mitochondrial dynamics in astrocytes [PDF]
Biochemical Society Transactions, 2014 Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca2+) levels in response to synaptic activity. Astrocyte Ca2+ elevations can trigger the release of neuroactive substances that can modulate synaptic transmission and plasticity, hence promoting bidirectional communication with neurons.
Stephen, TL +2 more
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