Results 61 to 70 of about 1,226,681 (303)

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis [PDF]

, 2010
Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS.
Turnbull, Doug M, Kim J. Krishnan, Iryna Ziabreva, Owain Howell, Graham R. Campbell, Don J. Mahad, Reynolds, Richard, Owen Howell, Mahad, Don J, Reeve, Amy K, Amy K. Reeve, Richard Reynolds, Ziabreva, Iryna, Campbell, Graham R, Lassmann, Hans, Doug M. Turnbull, Howell, Owen, Krishnan, Kim J, Hans Lassmann   +18 more
core   +1 more source

Mitochondrial dysfunction and its association with age-related disorders

Frontiers in Physiology
Aging is a complex process that features a functional decline in many organelles. Various factors influence the aging process, such as chromosomal abnormalities, epigenetic changes, telomere shortening, oxidative stress, and mitochondrial dysfunction ...
Indumathi Somasundaram, Samatha M. Jain, Marcel Blot-Chabaud, Surajit Pathak, Antara Banerjee, Sonali Rawat, Neeta Raj Sharma, Asim K. Duttaroy   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice [PDF]

, 2016
The kidney has a high energy demand and is dependent on oxidative metabolism for ATP production. Accordingly, the kidney is rich in mitochondria, and mitochondrial dysfunction is a common denominator for several renal diseases.
Handschin, Christoph, Kristoffer Svensson, Schnyder, Svenia, Christoph Handschin, Kristoffer Svensson (593634), Svenia Schnyder (3146877), Svensson, Kristoffer, Bettina Cardel (3146880), Svenia Schnyder, Christoph Handschin (184204), Cardel, Bettina, Bettina Cardel   +11 more
core   +1 more source

Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review

, 2022
Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease (DKD). Compared to the vast body of evidence from preclinical in vitro and in vivo studies, evidence from human studies is limited.
Pernoud, Laura, Gallo, Linda, Forbes, Josephine, Nicole Flemming, Laura Pernoud, Flemming, Nicole, Linda Gallo, Josephine Forbes   +7 more
core   +1 more source

Mitochondrial DNA Mutations and Mitochondrial Dysfunction in Epilepsy [PDF]

Epilepsia, 1999
Since the characterisation of mitochondrial DNA (mtDNA) in 1981 (l), interest in the potential role of mitochondria in human disease states has exponentially intensified. Our understanding of mitochondrial function has improved dramatically over the last decade (2), and with the identification of the first human pathogenetic mtDNA mutations in 1988 (3 ...
H, Cock, A H, Schapira
openaire   +2 more sources

Mitochondrial dysfunction in acute kidney injury

Renal Failure
Acute kidney injury (AKI) is a systemic clinical syndrome increasing morbidity and mortality worldwide in recent years. Renal tubular epithelial cells (TECs) death caused by mitochondrial dysfunction is one of the pathogeneses.
Congcong Yao, Ziwei Li, Keke Sun, Yan Zhang, Songtao Shou, Heng Jin   +5 more
doaj   +1 more source

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease

Parkinson's Disease, 2011
Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases as strict regulation of integrated mitochondrial functions is essential for neuronal signaling, plasticity, and transmitter release.
Kemal Ugur Tufekci, Ezgi Civi Bayin, Sermin Genc, Kursad Genc   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mitochondrial β-amyloid in Alzheimer's disease [PDF]

, 2011
This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA, James A. Ainge, Muirhead, Kirsty Elizabeth Adair, Gunn-Moore, FJ, Muirhead, KE, Laura Aitken, Aitken, Laura, Zoe E. Allen, Allen, Zoe Eleanor, Gunn-Moore, Frank J, Conway, Stuart, Frank J. Gunn-Moore, Allen, ZE, Borger, E, Aitken, L, Borger, Eva, Conway, SJ, Ainge, James Alexander, Kirsty E.A. Muirhead, Eva Borger, Stuart J. Conway   +20 more
core   +1 more source