Results 21 to 30 of about 17,435 (167)

Recent advances and new perspectives in mitochondrial dysfunction

Scientific Reports, 2023
In the last decade, there has been an increased appreciation for mitochondria as central hubs in diverse processes, such as cellular energy, immunity, and signal transduction.
Cecilia Giulivi, Kezhong Zhang, Hirofumi Arakawa   +2 more
doaj   +1 more source

Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo.

PLoS ONE, 2021
Mitochondrial dysfunction is significantly associated with neurological deficits and age-related neurological diseases. While mitochondria are dynamically regulated and properly maintained during neurogenesis, the manner in which mitochondrial activities
Rintaro Kuroda, Kaoru Tominaga, Katsumi Kasashima, Kenji Kuroiwa, Eiji Sakashita, Hiroko Hayakawa, Tom Kouki, Nobuhiko Ohno, Kensuke Kawai, Hitoshi Endo   +9 more
doaj   +1 more source

Advances in exercise to alleviate sarcopenia in older adults by improving mitochondrial dysfunction

Frontiers in Physiology, 2023
Sarcopenia is a chronic degenerative disease affecting primarily older adults. A growing aging population is gradually increasing the number of patients suffering from sarcopenia, placing increasing financial pressure on patients’ families and society in
Yang Zhu, Xuchang Zhou, Aiyuan Zhu, Shijing Xiong, Jun Xie, Zhenmin Bai   +5 more
doaj   +1 more source

Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway. [PDF]

PLoS ONE, 2016
Mitochondrial dysfunction plays a key role in the progression of Alzheimer's disease (AD). The accumulation of amyloid-beta peptide (Aβ) in the brains of AD patients is thought to be closely related to neuronal mitochondrial dysfunction and oxidative ...
Chunhui Zhao, Cui Lv, Hang Li, Shijing Du, Xiaoli Liu, Zhi Li, Wenfeng Xin, Wensheng Zhang   +7 more
doaj   +1 more source

Mitochondrial Regulation of Diabetic Kidney Disease

Frontiers in Medicine, 2021
The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood.
Daniel L. Galvan, Koki Mise, Koki Mise, Farhad R. Danesh, Farhad R. Danesh   +4 more
doaj   +1 more source

Mitochondrial dysfunction in heart failure and its therapeutic implications

Frontiers in Cardiovascular Medicine, 2022
The ATP consumption in heart is very intensive to support muscle contraction and relaxation. Mitochondrion is the power plant of the cell. Mitochondrial dysfunction has long been believed as the primary mechanism responsible for the inability of energy ...
Miaosen Liu, Jialan Lv, Zhicheng Pan, Dongfei Wang, Liding Zhao, Xiaogang Guo   +5 more
doaj   +1 more source

Secretory Phospholipase A2 in Patients With Sickle Cell Disease Hospitalized for Vaso‐Occlusive Pain Episodes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Secretory phospholipase A2 (sPLA2) is an inflammatory mediator linked to acute chest syndrome (ACS) in sickle cell disease (SCD), a serious complication that can develop during an acute vaso‐occlusive pain episode (VOE). Plasma sPLA2 levels have been proposed as a potential biomarker for predicting ACS onset.
Rawan Korman, Maria Yasmine, Dunia Hatabah, Noor Alzraikat, Frank Harris, Lou Ann Brown, Satheesh Chonat, Nitya Bakshi, Chris A. Rees, Carlton Dampier, Claudia R. Morris   +10 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mitigating mitochondrial dysfunction: a novel strategy for Chinese botanical drugs against osteoporosis

Frontiers in Pharmacology
Osteoporosis (OP) is a chronic metabolic disease characterized by reduced bone mass and impaired bone microstructure, posing a significant global health threat.
Shiyu Li, Hongyu Liu
doaj   +1 more source