Results 21 to 30 of about 388,773 (307)
Mitochondrial dysfunction in cell senescence and aging
The Journal of Clinical Investigation, 2022 Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane ...
Satomi Miwa +3 more
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International Journal of Oral Science, 2021 Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been shown to accelerate the progression of atherosclerosis (AS). However, the definite mechanisms remain elusive.
Tong Xu +6 more
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Advanced Science, 2023 Mitochondrial dysfunction has been recognized as the key pathogenesis of most neurodegenerative diseases including Alzheimer's disease (AD). The dysregulation of mitochondrial calcium ion (Ca2+) homeostasis and the mitochondrial permeability transition ...
Qian Zhang +10 more
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Mitochondrial Dysfunction in Cancer [PDF]
Frontiers in Oncology, 2013 A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research that is under-explored in terms of its significance for clinical management of cancer. Work discussed in this review focuses less on the Warburg effect and more on mitochondria and how dysfunctional
Boland, Michelle L. +2 more
openaire +3 more sources
Frontiers in Pharmacology, 2023 Metabolic syndrome (MS) is a complex group of metabolic disorders syndrome with hypertension, hyperuricemia and disorders of glucose or lipid metabolism. As an important organ involved in metabolism, the kidney is inevitably attacked by various metabolic
Peng Liu +5 more
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Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines
Scientific Reports, 2022 Mitochondrial dysfunction promotes cancer aggressiveness, metastasis, and resistance to therapy. Similar traits are associated with epithelial mesenchymal transition (EMT).
Maria do Carmo Greier +6 more
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Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]
, 2014 Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
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Mitochondrial Dysfunction in Attention Deficit Hyperactivity Disorder
, 2022 Attention deficit hyperactivity disorder is a neurodevelopmental disorder with primary symptoms of inat-tention, hyperactivity, and impulsivity, beginning in early childhood.
Öğütlü, Hakan +5 more
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The multifaceted roles of natural products in mitochondrial dysfunction
Frontiers in Pharmacology, 2023 Mitochondria are the primary source of energy production in cells, supporting the metabolic demand of tissue. The dysfunctional mitochondria are implicated in various diseases ranging from neurodegeneration to cancer.
Qianrun Chen +4 more
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Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor. [PDF]
, 2013 Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Maddock Helen +15 more
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