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Advanced Science, 2023 Mitochondrial dysfunction has been recognized as the key pathogenesis of most neurodegenerative diseases including Alzheimer's disease (AD). The dysregulation of mitochondrial calcium ion (Ca2+) homeostasis and the mitochondrial permeability transition ...
Qian Zhang +10 more
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Mitochondrial Dysfunction in Attention Deficit Hyperactivity Disorder [PDF]
, 2022 Attention deficit hyperactivity disorder is a neurodevelopmental disorder with primary symptoms of inat-tention, hyperactivity, and impulsivity, beginning in early childhood.
Öğütlü, Hakan +5 more
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Mitochondrial dysfunction and lipotoxicity [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010 Mitochondrial dysfunction in skeletal muscle has been suggested to underlie the development of insulin resistance and type 2 diabetes mellitus. Reduced mitochondrial capacity will contribute to the accumulation of lipid intermediates, desensitizing insulin signaling and leading to insulin resistance.
Schrauwen, P. +3 more
openaire +3 more sources
The crosstalk between HIFs and mitochondrial dysfunctions in cancer development
Cell Death and Disease, 2021 Mitochondria are essential cellular organelles that are involved in regulating cellular energy, metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic disease that is closely associated with mitochondrial dysfunction ...
Xingting Bao +7 more
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No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]
, 2013 Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV with intact ...
Turnbull, Doug M +5 more
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Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines
Scientific Reports, 2022 Mitochondrial dysfunction promotes cancer aggressiveness, metastasis, and resistance to therapy. Similar traits are associated with epithelial mesenchymal transition (EMT).
Maria do Carmo Greier +6 more
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Frontiers in Pharmacology, 2023 Metabolic syndrome (MS) is a complex group of metabolic disorders syndrome with hypertension, hyperuricemia and disorders of glucose or lipid metabolism. As an important organ involved in metabolism, the kidney is inevitably attacked by various metabolic
Peng Liu +5 more
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The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease
Frontiers in Neuroscience, 2018 Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD.
Ying Cheng, Feng Bai
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The multifaceted roles of natural products in mitochondrial dysfunction
Frontiers in Pharmacology, 2023 Mitochondria are the primary source of energy production in cells, supporting the metabolic demand of tissue. The dysfunctional mitochondria are implicated in various diseases ranging from neurodegeneration to cancer.
Qianrun Chen +4 more
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Recent advances and new perspectives in mitochondrial dysfunction
Scientific Reports, 2023 In the last decade, there has been an increased appreciation for mitochondria as central hubs in diverse processes, such as cellular energy, immunity, and signal transduction.
Cecilia Giulivi +2 more
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