Results 51 to 60 of about 5,116,336 (302)
Disruption of embryonic blood-CSF barrier in chick embryos reveals the actual importance of this barrier to control E-CSF composition and homeostasis in early brain development [PDF]
, 2013 In vertebrates, early brain development takes place at the expanded anterior end of the neural tube. After closure of the anterior neuropore, the brain wall forms a physiologically sealed cavity that encloses embryonic cerebrospinal fluid (E-CSF), a ...
Bueno i Torrens, David, 1965- +1 more
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METTL3 regulates WTAP protein homeostasis [PDF]
Cell Death & Disease, 2018 AbstractThe Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Sorci, Melissa +8 more
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Mutational analysis of the AtNUDT7 Nudix hydrolase from Arabidopsis thaliana reveals residues required for protein quaternary structure formation and activity. [PDF]
, 2009 Arabidopsis thaliana AtNUDT7, a homodimeric Nudix hydrolase active on ADP-ribose and NADH, exerts negative control on the major signaling complex involved in plant defense activation and programmed cell death.
Goch, Grażyna +6 more
core +1 more source
Bio-ProtocolAccurate measurement of protein translation rates is crucial for understanding cellular processes and disease mechanisms. However, existing methods for quantifying translation rates in yeast cells are limited.
Mainak Jha, Koyeli Mapa
doaj +1 more source
Integrating Protein Homeostasis Strategies in Prokaryotes [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Bacterial cells are frequently exposed to dramatic fluctuations in their environment, which cause perturbation in protein homeostasis and lead to protein misfolding. Bacteria have therefore evolved powerful quality control networks consisting of chaperones and proteases that cooperate to monitor the folding states of proteins and to remove misfolded ...
Axel, Mogk, Damon, Huber, Bernd, Bukau
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Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]
, 2018 Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias +5 more
core +2 more sources
Protein folding, protein homeostasis, and cancer [PDF]
Chinese Journal of Cancer, 2011 Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links
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Impact of ER Protein Homeostasis on Metabolism [PDF]
Diabetes, 2013 Proper regulation of protein homeostasis in a cell is critical for the health of the organism. Proteins, intracellular or secreted, need to be produced and maintained at the right quantity, folded into their three-dimensional conformation with necessary posttranslational modifications, targeted to their correct destinations to insure their optimal ...
Yalcin, Abdullah, Hotamisligil, Gokhan
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Journal of Cardiovascular Development and Disease, 2023 Dilated cardiomyopathy (DCM) is a common heart muscle disorder that frequently leads to heart failure, arrhythmias, and death. While DCM is often heritable, disease-causing mutations are identified in only ~30% of cases.
Inken G. Huttner +11 more
doaj +1 more source
Expressed protein ligation for a large dimeric protein [PDF]
, 2011 Expressed protein ligation (EPL) is a protein engineering tool for post-translational ligation of protein or peptide fragments. This technique allows modification of specific parts of proteins, opening possibilities for incorporating probes for ...
NMR Spectroscopy +11 more
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