Results 1 to 10 of about 2,162,392 (300)

Protein quality control of cell stemness [PDF]

Cell Regeneration, 2020
Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis.
Pengze Yan, Jie Ren, Weiqi Zhang, Jing Qu, Guang-Hui Liu   +4 more
doaj   +3 more sources

Modulating protein quality control

eLife, 2016
Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
Lars Plate, Ryan J Paxman, R Luke Wiseman, Jeffery W Kelly   +3 more
doaj   +3 more sources

Protein Quality Control in the Nucleus [PDF]

Biomolecules, 2014
In their natural environment, cells are regularly exposed to various stress conditions that may lead to protein misfolding, but also in the absence of stress, misfolded proteins occur as the result of mutations or failures during protein synthesis. Since
Sofie V. Nielsen, Esben G. Poulsen, Caio A. Rebula, Rasmus Hartmann-Petersen   +3 more
doaj   +5 more sources

USP5 enhances SGTA mediated protein quality control. [PDF]

PLoS ONE, 2022
Mislocalised membrane proteins (MLPs) present a risk to the cell due to exposed hydrophobic amino acids which cause MLPs to aggregate. Previous studies identified SGTA as a key component of the machinery that regulates the quality control of MLPs ...
Jake Hill, Yvonne Nyathi
doaj   +4 more sources

Paralogue-Specific Roles of SUMO1 and SUMO2/3 in Protein Quality Control and Associated Diseases [PDF]

Cells, 2023
Small ubiquitin-related modifiers (SUMOs) function as post-translational protein modifications and regulate nearly every aspect of cellular function. While a single ubiquitin protein is expressed across eukaryotic organisms, multiple SUMO paralogues with
Wei Wang, Michael J. Matunis
doaj   +2 more sources

Protein quality control gone awry in Alzheimer’s [PDF]

Aging Brain
Sadashiva K. Pai
doaj   +2 more sources

Mitochondrial Protein Quality Control Mechanisms [PDF]

Genes, 2020
Mitochondria serve as a hub for many cellular processes, including bioenergetics, metabolism, cellular signaling, redox balance, calcium homeostasis, and cell death. The mitochondrial proteome includes over a thousand proteins, encoded by both the mitochondrial and nuclear genomes.
Pooja Jadiya, Dhanendra Tomar
openaire   +2 more sources

Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells

Cell Communication and Signaling, 2022
Background Lung cancer remains a major cause of cancer-related mortality throughout the world at present. Repositioning of existing drugs for other diseases is a promising strategy for cancer therapies, which may rapidly advance potentially promising ...
Junwan Lu, Yujie Li, Shiwei Gong, Jiaxin Wang, Xiaoang Lu, Qiumei Jin, Bin Lu, Qin Chen   +7 more
doaj   +1 more source

Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells

Cell Death and Disease, 2022
Ciclopirox (CPX), an antifungal drug, has recently been identified as a promising agent for cancer treatment. However, the effects and underlying mechanism of CPX as an antitumor agent of gastric cancer (GC) remain largely unknown.
Lingyan Chen, Dejian Chen, Jiwei Li, Lipeng He, Ting Chen, Dandan Song, Shuang Shan, Jiaxin Wang, Xiaoang Lu, Bin Lu   +9 more
doaj   +1 more source

Gene Signature Associated With Bromodomain Genes Predicts the Prognosis of Kidney Renal Clear Cell Carcinoma

Frontiers in Genetics, 2021
Bromodomain (BRD) proteins exhibit a variety of activities, such as histone modification, transcription factor recruitment, chromatin remodeling, and mediator or enhancer complex assembly, that affect transcription initiation and elongation.
Junwan Lu, Changrui Qian, Yongan Ji, Qiyu Bao, Bin Lu   +4 more
doaj   +1 more source