Results 1 to 10 of about 22,982,554 (304)

Methionine Redox Homeostasis in Protein Quality Control

Frontiers in Molecular Biosciences, 2021
Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress.
Laurent Aussel, Benjamin Ezraty
doaj   +3 more sources

Mechanisms and Functions of Ribosome-Associated Protein Quality Control

Nature Reviews Molecular Cell Biology, 2019
The stalling of ribosomes during protein synthesis results in the production of truncated polypeptides that can have deleterious effects on cells and therefore must be eliminated.
Claudio A P Joazeiro
exaly   +2 more sources

Misfolding and aggregation in neurodegenerative diseases: protein quality control machinery as potential therapeutic clearance pathways. [PDF]

Cell Commun Signal
The primary challenge in today’s world of neuroscience is the search for new therapeutic possibilities for neurodegenerative disease. Central to these disorders lies among other factors, the aberrant folding, aggregation, and accumulation of proteins ...
Koszła O, Sołek P.
europepmc   +2 more sources

Protein quality control of cell stemness

Cell Regeneration, 2020
Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis.
Pengze Yan, Jie Ren, Weiqi Zhang, Jing Qu, Guang-Hui Liu   +4 more
doaj   +2 more sources

Paralogue-Specific Roles of SUMO1 and SUMO2/3 in Protein Quality Control and Associated Diseases [PDF]

Cells, 2023
Small ubiquitin-related modifiers (SUMOs) function as post-translational protein modifications and regulate nearly every aspect of cellular function. While a single ubiquitin protein is expressed across eukaryotic organisms, multiple SUMO paralogues with
Wei Wang, Michael J. Matunis
doaj   +2 more sources

Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control

Science Advances, 2023
Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with intracellular proteins through ufmylation, similar to ubiquitylation.
Ryosuke Ishimura, Sota Ito, Gaoxin Mao, Satoko Komatsu-Hirota, Toshifumi Inada, N. Noda, M. Komatsu   +6 more
semanticscholar   +1 more source

Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT

Nature Cell Biology, 2023
Effective protein quality control (PQC), essential for cellular health, relies on spatial sequestration of misfolded proteins into defined inclusions. Here we reveal the coordination of nuclear and cytoplasmic spatial PQC.
E. Sontag, Fábian Morales-Polanco, Jian-Hua Chen, G. McDermott, Patrick T. Dolan, D. Gestaut, M. Le Gros, C. Larabell, J. Frydman   +8 more
semanticscholar   +1 more source

The role of the proteasome in mitochondrial protein quality control

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2023
The abundance of each cellular protein is dynamically adjusted to the prevailing metabolic and stress conditions by modulation of their synthesis and degradation rates.
Saskia Rödl, Johannes M. Herrmann
semanticscholar   +1 more source

Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells

Cell Communication and Signaling, 2022
Background Lung cancer remains a major cause of cancer-related mortality throughout the world at present. Repositioning of existing drugs for other diseases is a promising strategy for cancer therapies, which may rapidly advance potentially promising ...
Junwan Lu, Yujie Li, Shiwei Gong, Jiaxin Wang, Xiaoang Lu, Qiumei Jin, Bin Lu, Qin Chen   +7 more
doaj   +1 more source

Protein quality control gone awry in Alzheimer’s [PDF]

Aging Brain
Sadashiva K. Pai
doaj   +2 more sources