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Protein Quality Control in the Nucleus [PDF]
Biomolecules, 2014 In their natural environment, cells are regularly exposed to various stress conditions that may lead to protein misfolding, but also in the absence of stress, misfolded proteins occur as the result of mutations or failures during protein synthesis. Since
Sofie V. Nielsen +3 more
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Protein quality control meets transcriptome remodeling under stress [PDF]
Cell Stress, 2017 To tolerate and recover from genotoxic stress cells must coordinate a range of stress response activities including cell cycle arrest, DNA repair, and remodeling of the transcriptome and proteome.
Veena Mathew, Peter C. Stirling
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Protein quality control of cell stemness [PDF]
Cell Regeneration, 2020 Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis.
Pengze Yan +4 more
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Modulating protein quality control
eLife, 2016 Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
Lars Plate +3 more
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Protein Quality Control at the Mitochondrial Surface [PDF]
Frontiers in Cell and Developmental Biology, 2021 Mitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of ...
Fabian den Brave +2 more
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USP5 enhances SGTA mediated protein quality control. [PDF]
PLoS ONE, 2022 Mislocalised membrane proteins (MLPs) present a risk to the cell due to exposed hydrophobic amino acids which cause MLPs to aggregate. Previous studies identified SGTA as a key component of the machinery that regulates the quality control of MLPs ...
Jake Hill, Yvonne Nyathi
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Protein quality control in the bacterial periplasm [PDF]
Microbial Cell Factories, 2004 The proper functioning of extracytoplasmic proteins requires their export to, and productive folding in, the correct cellular compartment. All proteins in Escherichia coli are initially synthesized in the cytoplasm, then follow a pathway that depends ...
Betton Jean-Michel, Miot Marika
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Mitochondrial Protein Quality Control Mechanisms [PDF]
Genes, 2020 Mitochondria serve as a hub for many cellular processes, including bioenergetics, metabolism, cellular signaling, redox balance, calcium homeostasis, and cell death.
Pooja Jadiya, Dhanendra Tomar
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Methionine Redox Homeostasis in Protein Quality Control
Frontiers in Molecular Biosciences, 2021 Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress.
Laurent Aussel, Benjamin Ezraty
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Paralogue-Specific Roles of SUMO1 and SUMO2/3 in Protein Quality Control and Associated Diseases [PDF]
Cells, 2023 Small ubiquitin-related modifiers (SUMOs) function as post-translational protein modifications and regulate nearly every aspect of cellular function. While a single ubiquitin protein is expressed across eukaryotic organisms, multiple SUMO paralogues with
Wei Wang, Michael J. Matunis
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