Results 1 to 10 of about 19,078,260 (300)

Paralogue-Specific Roles of SUMO1 and SUMO2/3 in Protein Quality Control and Associated Diseases [PDF]

Cells, 2023
Small ubiquitin-related modifiers (SUMOs) function as post-translational protein modifications and regulate nearly every aspect of cellular function. While a single ubiquitin protein is expressed across eukaryotic organisms, multiple SUMO paralogues with
Wei Wang, Michael J. Matunis
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Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells

Cell Communication and Signaling, 2022
Background Lung cancer remains a major cause of cancer-related mortality throughout the world at present. Repositioning of existing drugs for other diseases is a promising strategy for cancer therapies, which may rapidly advance potentially promising ...
Junwan Lu, Yujie Li, Shiwei Gong, Jiaxin Wang, Xiaoang Lu, Qiumei Jin, Bin Lu, Qin Chen   +7 more
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Protein quality control gone awry in Alzheimer’s [PDF]

Aging Brain
Sadashiva K. Pai
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Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells

Cell Death and Disease, 2022
Ciclopirox (CPX), an antifungal drug, has recently been identified as a promising agent for cancer treatment. However, the effects and underlying mechanism of CPX as an antitumor agent of gastric cancer (GC) remain largely unknown.
Lingyan Chen, Dejian Chen, Jiwei Li, Lipeng He, Ting Chen, Dandan Song, Shuang Shan, Jiaxin Wang, Xiaoang Lu, Bin Lu   +9 more
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Gene Signature Associated With Bromodomain Genes Predicts the Prognosis of Kidney Renal Clear Cell Carcinoma

Frontiers in Genetics, 2021
Bromodomain (BRD) proteins exhibit a variety of activities, such as histone modification, transcription factor recruitment, chromatin remodeling, and mediator or enhancer complex assembly, that affect transcription initiation and elongation.
Junwan Lu, Changrui Qian, Yongan Ji, Qiyu Bao, Bin Lu   +4 more
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Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways

Cell & Bioscience, 2021
Background Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases.
Xianglin Mei, Hanhan Zhao, Huihan Ai, Shuyue Wang, Zhenbo Song, Lihua Zheng, Guannan Wang, Ying Sun, Yongli Bao   +8 more
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SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN®, induces robust humoral and cellular immunity in mice and non-human primates

npj Vaccines, 2022
At the forefront of biopharmaceutical industry, the messenger RNA (mRNA) technology offers a flexible and scalable platform to address the urgent need for world-wide immunization in pandemic situations.
Reza Alimohammadi, Meysam Porgoo, Mohamad Eftekhary, Seyed Hossein Kiaie, Ehsan Ansari Dezfouli, Maryam Dehghani, Kaveh Nasrollahi, Talieh Malekshahabi, Maryam Heidari, Sedigheh Pouya, Masoumeh Alimohammadi, Dorsa Sattari Khavas, Mohammad Sadra Modaresi, Mohammad Hossein Ghasemi, Hamed Ramyar, Fatemeh Mohammadipour, Fateme Hamzelouei, Ahmadreza Mofayezi, Seyed Saeed Mottaghi, Amirhosein Rahmati, Mohsen Razzaznian, Vista Tirandazi, Mahdi Tat, Fatemeh Borzouee, Hossein Sadeghi, Melika Haji Mohammadi, Leila Rastegar, Seyed Milad Safar Sajadi, Hossein Ehsanbakhsh, Hamed Bazmbar, Zeinab Baghernejadan, Maedeh Shams Nouraei, Pouya Pazooki, Mina Pahlavanneshan, Khadijeh Alishah, Fateme Nasiri, Neda Mokhberian, Seyedeh Shima Mohammadi, Shima Akar, Hamidreza Niknam, Marzieh Azizi, Mohammad Ajoudanian, Mohammad Hossein Moteallehi-Ardakani, Seyed Ali Mousavi Shaegh, Reihaneh Ramezani, Vahid Salimi, Reza Moazzami, Seyed Mahmoud Hashemi, Somaye Dehghanizadeh, Vahid Khoddami   +49 more
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Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

Frontiers in Microbiology, 2021
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are the virulence determinants of cariogenic biofilms.
Yucui Liu, Yucui Liu, Yanxin Huang, Cong Fan, Cong Fan, Zhongmei Chi, Miao Bai, Luguo Sun, Li Yang, Chunlei Yu, Zhenbo Song, Xiaoguang Yang, Xiaoguang Yang, Jingwen Yi, Jingwen Yi, Shuyue Wang, Lei Liu, Guannan Wang, Lihua Zheng   +18 more
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Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

Cell Death and Disease, 2021
Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown.
Zhipeng Su, Shengnan Han, Qiumei Jin, Ningning Zhou, Junwan Lu, Fugen Shangguan, Shiyi Yu, Yongzhang Liu, Lu Wang, Jianglong Lu, Qun Li, Lin Cai, Chengde Wang, Xiaohe Tian, Lingyan Chen, Weiming Zheng, Bin Lu   +16 more
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N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth

Redox Biology, 2022
Despite the evidences of elevated expression of Mer tyrosine kinase (MerTK) in multiple human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular carcinoma (HCC) remains undefined. We explored the functional effects of MerTK and
Yongzhang Liu, Linhua Lan, Yujie Li, Jing Lu, Lipeng He, Yao Deng, Mingming Fei, Jun-Wan Lu, Fugen Shangguan, Ju-Ping Lu, Jiaxin Wang, Liang Wu, Kate Huang, Bin Lu   +13 more
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