Results 11 to 20 of about 2,162,392 (300)

Molecular Chaperones and Protein Quality Control

Cell, 2006
In living cells, both newly made and preexisting polypeptide chains are at constant risk for misfolding and aggregation. In accordance with the wide diversity of misfolded forms, elaborate quality-control strategies have evolved to counter these inevitable mishaps.
Bukau, Bernd, Weissman, Jonathan, Horwich, Arthur   +2 more
openaire   +4 more sources

Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways

Cell & Bioscience, 2021
Background Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases.
Xianglin Mei, Hanhan Zhao, Huihan Ai, Shuyue Wang, Zhenbo Song, Lihua Zheng, Guannan Wang, Ying Sun, Yongli Bao   +8 more
doaj   +1 more source

Ribosome-associated protein quality control [PDF]

Nature Structural & Molecular Biology, 2016
Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA, insufficient availability of charged tRNAs and genetic errors. All organisms have evolved mechanisms to recognize stalled ribosomes and initiate pathways for recycling, quality control and stress signaling. Here we review the discovery and molecular dissection of the
Onn, Brandman, Ramanujan S, Hegde
openaire   +2 more sources

SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN®, induces robust humoral and cellular immunity in mice and non-human primates

npj Vaccines, 2022
At the forefront of biopharmaceutical industry, the messenger RNA (mRNA) technology offers a flexible and scalable platform to address the urgent need for world-wide immunization in pandemic situations.
Reza Alimohammadi, Meysam Porgoo, Mohamad Eftekhary, Seyed Hossein Kiaie, Ehsan Ansari Dezfouli, Maryam Dehghani, Kaveh Nasrollahi, Talieh Malekshahabi, Maryam Heidari, Sedigheh Pouya, Masoumeh Alimohammadi, Dorsa Sattari Khavas, Mohammad Sadra Modaresi, Mohammad Hossein Ghasemi, Hamed Ramyar, Fatemeh Mohammadipour, Fateme Hamzelouei, Ahmadreza Mofayezi, Seyed Saeed Mottaghi, Amirhosein Rahmati, Mohsen Razzaznian, Vista Tirandazi, Mahdi Tat, Fatemeh Borzouee, Hossein Sadeghi, Melika Haji Mohammadi, Leila Rastegar, Seyed Milad Safar Sajadi, Hossein Ehsanbakhsh, Hamed Bazmbar, Zeinab Baghernejadan, Maedeh Shams Nouraei, Pouya Pazooki, Mina Pahlavanneshan, Khadijeh Alishah, Fateme Nasiri, Neda Mokhberian, Seyedeh Shima Mohammadi, Shima Akar, Hamidreza Niknam, Marzieh Azizi, Mohammad Ajoudanian, Mohammad Hossein Moteallehi-Ardakani, Seyed Ali Mousavi Shaegh, Reihaneh Ramezani, Vahid Salimi, Reza Moazzami, Seyed Mahmoud Hashemi, Somaye Dehghanizadeh, Vahid Khoddami   +49 more
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Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

Frontiers in Microbiology, 2021
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are the virulence determinants of cariogenic biofilms.
Yucui Liu, Yucui Liu, Yanxin Huang, Cong Fan, Cong Fan, Zhongmei Chi, Miao Bai, Luguo Sun, Li Yang, Chunlei Yu, Zhenbo Song, Xiaoguang Yang, Xiaoguang Yang, Jingwen Yi, Jingwen Yi, Shuyue Wang, Lei Liu, Guannan Wang, Lihua Zheng   +18 more
doaj   +1 more source

Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

Cell Death and Disease, 2021
Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown.
Zhipeng Su, Shengnan Han, Qiumei Jin, Ningning Zhou, Junwan Lu, Fugen Shangguan, Shiyi Yu, Yongzhang Liu, Lu Wang, Jianglong Lu, Qun Li, Lin Cai, Chengde Wang, Xiaohe Tian, Lingyan Chen, Weiming Zheng, Bin Lu   +16 more
doaj   +1 more source

Quality Control of Orphaned Proteins [PDF]

Molecular Cell, 2018
The billions of proteins inside a eukaryotic cell are organized among dozens of sub-cellular compartments, within which they are further organized into protein complexes. The maintenance of both levels of organization is crucial for normal cellular function. Newly made proteins that fail to be segregated to the correct compartment or assembled into the
Szymon, Juszkiewicz, Ramanujan S, Hegde
openaire   +2 more sources

N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth

Redox Biology, 2022
Despite the evidences of elevated expression of Mer tyrosine kinase (MerTK) in multiple human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular carcinoma (HCC) remains undefined. We explored the functional effects of MerTK and
Yongzhang Liu, Linhua Lan, Yujie Li, Jing Lu, Lipeng He, Yao Deng, Mingming Fei, Jun-Wan Lu, Fugen Shangguan, Ju-Ping Lu, Jiaxin Wang, Liang Wu, Kate Huang, Bin Lu   +13 more
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PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy

Cell & Bioscience, 2022
Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN.
Thomas Fischer, Oliver Hartmann, Michaela Reissland, Cristian Prieto-Garcia, Kevin Klann, Nikolett Pahor, Christina Schülein-Völk, Apoorva Baluapuri, Bülent Polat, Arya Abazari, Elena Gerhard-Hartmann, Hans-Georg Kopp, Frank Essmann, Mathias Rosenfeldt, Christian Münch, Michael Flentje, Markus E. Diefenbacher   +16 more
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USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

Molecular Oncology, 2022
Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Süleyman Bozkurt, Nikolett Pahor, Carmina Fuss, Andreas Schirbel, Christina Schülein‐Völk, Alexander Buchberger, Marco A. Calzado Canale, Mathias Rosenfeldt, Ivan Dikic, Christian Münch, Markus E. Diefenbacher   +14 more
doaj   +1 more source