Results 11 to 20 of about 1,305,355 (298)
Protein Quality Control in the Bacterial Periplasm
Annual Review of Microbiology, 2011 Protein quality control involves sensing and treatment of defective or incomplete protein structures. Misfolded or mislocalized proteins trigger dedicated signal transduction cascades that upregulate the production of protein quality-control factors ...
Merdanovic, Melisa +14 more
core +5 more sources
Nucleolus: A Protein Quality Control Compartment
Trends in Biochemical Sciences, 2019 Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat ...
Suresh, S N, Rekulapally, Pavani
core +4 more sources
Protein quality control at the mitochondrion
Essays in Biochemistry, 2016 Mitochondria are essential constituents of a eukaryotic cell by supplying ATP and contributing to many mayor metabolic processes. As endosymbiotic organelles, they represent a cellular subcompartment exhibiting many autonomous functions, most importantly
Michael Bruderek +3 more
core +3 more sources
Mitochondrial protein synthesis quality control
Human Molecular GeneticsHuman mitochondrial DNA is one of the most simplified cellular genomes and facilitates compartmentalized gene expression. Within the organelle, there is no physical barrier to separate transcription and translation, nor is there evidence that quality ...
Battersby, Brendan J. +1 more
core +4 more sources
Molecular Chaperones and Protein Quality Control
Cell, 2006 In living cells, both newly made and preexisting polypeptide chains are at constant risk for misfolding and aggregation. In accordance with the wide diversity of misfolded forms, elaborate quality-control strategies have evolved to counter these ...
Horwich, Arthur +2 more
core +3 more sources
How do protein aggregates escape quality control in neurodegeneration? [PDF]
, 2022 Protein aggregates are hallmarks of neurodegenerative diseases. The protein quality control (PQC) system normally prevents proteins from misfolding and accumulation; however, proteins somehow escape this control on disease. Here we review advances in the
Ferrari, Luca +2 more
core +2 more sources
Protein quality control gone awry in Alzheimer’s [PDF]
Aging BrainSadashiva K. Pai
doaj +2 more sources
Protein quality control at the Golgi
Current Opinion in Cell Biology, 2022 The majority of the proteome in eukaryotic cells is targeted to organelles. To maintain protein homeostasis (proteostasis), distinct protein quality control (PQC) machineries operate on organelles, where they detect misfolded proteins, orphaned and mis-localized proteins and selectively target these proteins into different ubiquitin-dependent or ...
Sinead Schwabl, David Teis
openaire +2 more sources
Cell Communication and Signaling, 2022 Background Lung cancer remains a major cause of cancer-related mortality throughout the world at present. Repositioning of existing drugs for other diseases is a promising strategy for cancer therapies, which may rapidly advance potentially promising ...
Junwan Lu +7 more
doaj +1 more source
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells
Cell Death and Disease, 2022 Ciclopirox (CPX), an antifungal drug, has recently been identified as a promising agent for cancer treatment. However, the effects and underlying mechanism of CPX as an antitumor agent of gastric cancer (GC) remain largely unknown.
Lingyan Chen +9 more
doaj +1 more source