Results 11 to 20 of about 19,078,260 (300)
Modulating protein quality control
eLife, 2016 Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
Lars Plate +3 more
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Protein Quality Control in the Nucleus [PDF]
Biomolecules, 2014 In their natural environment, cells are regularly exposed to various stress conditions that may lead to protein misfolding, but also in the absence of stress, misfolded proteins occur as the result of mutations or failures during protein synthesis. Since
Sofie V. Nielsen +3 more
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Protein quality control meets transcriptome remodeling under stress [PDF]
Cell Stress, 2017 To tolerate and recover from genotoxic stress cells must coordinate a range of stress response activities including cell cycle arrest, DNA repair, and remodeling of the transcriptome and proteome.
Veena Mathew, Peter C. Stirling
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Protein quality control of cell stemness [PDF]
Cell Regeneration, 2020 Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis.
Pengze Yan +4 more
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Protein quality control in the bacterial periplasm [PDF]
Microbial Cell Factories, 2004 The proper functioning of extracytoplasmic proteins requires their export to, and productive folding in, the correct cellular compartment. All proteins in Escherichia coli are initially synthesized in the cytoplasm, then follow a pathway that depends ...
Betton Jean-Michel, Miot Marika
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Protein Quality Control at the Mitochondrial Surface [PDF]
Frontiers in Cell and Developmental Biology, 2021 Mitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of ...
Fabian den Brave +2 more
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How do protein aggregates escape quality control in neurodegeneration? [PDF]
, 2022 Protein aggregates are hallmarks of neurodegenerative diseases. The protein quality control (PQC) system normally prevents proteins from misfolding and accumulation; however, proteins somehow escape this control on disease. Here we review advances in the
Ferrari, Luca +2 more
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Protein quality control at the Golgi
Current Opinion in Cell Biology, 2022 The majority of the proteome in eukaryotic cells is targeted to organelles. To maintain protein homeostasis (proteostasis), distinct protein quality control (PQC) machineries operate on organelles, where they detect misfolded proteins, orphaned and mis-localized proteins and selectively target these proteins into different ubiquitin-dependent or ...
Sinead Schwabl, David Teis
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Protein quality control in the nucleus [PDF]
Current Opinion in Cell Biology, 2016 The nucleus is the repository for the eukaryotic cell's genetic blueprint, which must be protected from harm to ensure survival. Multiple quality control (QC) pathways operate in the nucleus to maintain the integrity of the DNA, the fidelity of the DNA code during replication, its transcription into mRNA, and the functional structure of the proteins ...
Ramon D, Jones, Richard G, Gardner
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Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint [PDF]
, 2021 Removal of the membrane-tethering signal peptides that target secretory proteins to the endoplasmic reticulum is a prerequisite for proper folding.
Sub Cellular Protein Chemistry +10 more
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