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Heart Failure and Protein Quality Control [PDF]
Circulation Research, 2006 The heart is constantly under mechanical, metabolic, and thermal stress, even at baseline physiological conditions, and cardiac stress may increase as a result of environmental or intrinsic pathological insults. Cardiomyocytes are continuously challenged to efficiently and properly fold nascent polypeptides, traffic them to their appropriate cellular ...
Xuejun, Wang, Jeffrey, Robbins
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Quality control in protein synthesis [PDF]
Biochimie, 2015 Editorial: In all living cells, protein synthesis (also named translation) is a complex and dynamic process mediated by the ribosome. It allows for an accurate correspondence between the genetic information and newly synthesized proteins. While the basics of translation have been known for several decades, the details of how ribosomes perform their ...
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Protein quality control and degradation in cardiomyocytes [PDF]
Journal of Molecular and Cellular Cardiology, 2008 The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system ...
Xuejun, Wang, Huabo, Su, Mark J, Ranek
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Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
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The Ribosome as a Hub for Protein Quality Control [PDF]
Molecular Cell, 2013 Cells face a constant challenge as they produce new proteins. The newly synthesized polypeptides must be folded properly to avoid aggregation. If proteins do misfold, they must be cleared to maintain a functional and healthy proteome. Recent work is revealing the complex mechanisms that work cotranslationally to ensure protein quality control during ...
Pechmann, Sebastian +2 more
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A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]
, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela +23 more
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Protein Folding and Quality Control in the ER [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER quality control (ERQC) system. The ERQC facilitates folding and modification of secretory and membrane proteins and eliminates terminally misfolded polypeptides through ER-associated degradation (ERAD) or autophagic degradation.
Kazutaka, Araki, Kazuhiro, Nagata
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Protein quality in wheat [PDF]
, 2004 The overall objective of the present studies was to increase the understanding about protein quality in wheat, i.e. to make it possible to improve the production of wheat with desired quality for different end-uses.
Kuktaite, Ramune
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Methionine Redox Homeostasis in Protein Quality Control
Frontiers in Molecular Biosciences, 2021 Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress.
Laurent Aussel, Benjamin Ezraty
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Protein Quality Control in Health and Disease [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Maintaining functional protein homeostasis (proteostasis) is a constant challenge in the face of limited protein-folding capacity, environmental threats, and aging. Cells have developed several quality-control mechanisms that assist nascent polypeptides to fold properly, clear misfolded molecules, respond to the accumulation of protein aggregates, and ...
Tatyana, Dubnikov +2 more
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