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Protein Quality Control at the Mitochondrial Surface
Frontiers in Cell and Developmental Biology, 2021 Mitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of ...
Fabian den Brave +2 more
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Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses [PDF]
, 2016 ACKNOWLEDGMENTS We thank Dennis Winge (University of Utah) and the members of the Khalimonchuk laboratory for critical comments. We also thank Christoph Schuller (University of Natural Resources, Austria) and Paul Herman (Ohio State University) for ...
Barrientos, Antoni +10 more
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Methionine Redox Homeostasis in Protein Quality Control
Frontiers in Molecular Biosciences, 2021 Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress.
Laurent Aussel, Benjamin Ezraty
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The protein quality control system in motoneuron diseases [PDF]
, 2015 Spinal and bulbar muscular atrophy (SBMA) is a motoneuronal diseases caused by an elogated polyglutamine (polyQ) tract in the androgen receptor (AR).
Angelo Poletti +8 more
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Protein quality control meets transcriptome remodeling under stress
Cell Stress, 2017 To tolerate and recover from genotoxic stress cells must coordinate a range of stress response activities including cell cycle arrest, DNA repair, and remodeling of the transcriptome and proteome.
Veena Mathew, Peter C. Stirling
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Quality control of integral membrane proteins
Trends in Biochemical Sciences, 2004 Integral membrane proteins (IMPs) are essential components of the plasma and organellar membranes of the eukaryotic cell. Non-native IMPs, which can arise as a result of mutations, errors during biosynthesis or cellular stress, can disrupt these membranes and potentially lead to cell death.
Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32610, USA ( host institution ) +4 more
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Cellular Strategies of Protein Quality Control [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Eukaryotic cells must contend with a continuous stream of misfolded proteins that compromise the cellular protein homeostasis balance and jeopardize cell viability. An elaborate network of molecular chaperones and protein degradation factors continually monitor and maintain the integrity of the proteome. Cellular protein quality control relies on three
Bryan, Chen +3 more
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Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry [PDF]
, 2020 It is important to assess the identity and purity of proteins and protein complexes during and after protein purification to ensure that samples are of sufficient quality for further biochemical and structural characterization, as well as for use in ...
Baker, David +8 more
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TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]
, 2014 The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R +22 more
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Differential Scales of Protein Quality Control [PDF]
Cell, 2014 Proteins are notorious for their unpleasant behavior-continually at risk of misfolding, collecting damage, aggregating, and causing toxicity and disease. To counter these challenges, cells have evolved elaborate chaperone and quality control networks that can resolve damage at the level of the protein, organelle, cell, or tissue. On the smallest scale,
Wolff, Suzanne +2 more
openaire +2 more sources