Results 41 to 50 of about 1,305,355 (298)
Fishes, 2022 Acute hepatopancreatic necrosis disease (AHPND) caused by Vibrio parahaemolyticus (VpAHPND) has been reported in commodity shrimp, but the potential risk of its global spread via frozen shrimp in the shrimp trade is yet to be fully explored.
Chorong Lee +7 more
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The protein quality control and neurodegeneration
Folia Pharmacologica Japonica, 2003 There are growing lines of evidence addressing a potential link between failure of protein quality control and neurodegeneration. Hence, it is important to know the quality control mechanism of the cell for understanding the molecular basis underlying neurodegenerative diseases.
TANAKA, Keiji, MURATA, Shigeo
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Membrane protein folding and quality control
Current Opinion in Structural Biology, 2021 Membrane proteins account for a quarter of cellular proteins, and most are synthesised at the endoplasmic reticulum (ER). Insertion and folding of polypeptides in the membrane environment is prone to error, necessitating diverse quality control systems.
Ben P. Phillips, Elizabeth A. Miller
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Protein quality control of N-methyl-D-aspartate receptors
Frontiers in Cellular Neuroscience, 2022 N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated cation channels that mediate excitatory neurotransmission and are critical for synaptic development and plasticity in the mammalian central nervous system (CNS). Functional NMDARs typically form
Taylor M. Benske +2 more
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SGTA regulates the cytosolic quality control of hydrophobic substrates [PDF]
, 2014 Hydrophobic amino acids are normally shielded from the cytosol and their exposure is often used as an indicator of protein misfolding to enable the chaperone-mediated recognition and quality control of aberrant polypeptides.
Payapilly, Aishwarya +4 more
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Molecular mechanism of Asi- mediated protein quality control
, 2020 Misfolded proteins in the membrane and lumen of the endoplasmic reticulum (ER) are eliminated by a quality control system called ER-associated protein degradation (ERAD).
Natarajan, Nivedita
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Heart Failure and Protein Quality Control [PDF]
Circulation Research, 2006 The heart is constantly under mechanical, metabolic, and thermal stress, even at baseline physiological conditions, and cardiac stress may increase as a result of environmental or intrinsic pathological insults. Cardiomyocytes are continuously challenged to efficiently and properly fold nascent polypeptides, traffic them to their appropriate cellular ...
Xuejun, Wang, Jeffrey, Robbins
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Quality control in protein synthesis [PDF]
Biochimie, 2015 Editorial: In all living cells, protein synthesis (also named translation) is a complex and dynamic process mediated by the ribosome. It allows for an accurate correspondence between the genetic information and newly synthesized proteins. While the basics of translation have been known for several decades, the details of how ribosomes perform their ...
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Protein quality control and degradation in cardiomyocytes [PDF]
Journal of Molecular and Cellular Cardiology, 2008 The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system ...
Xuejun, Wang, Huabo, Su, Mark J, Ranek
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A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]
, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela +23 more
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