A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]
, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela +24 more
core +1 more source
Protein quality control of N-methyl-D-aspartate receptors
Frontiers in Cellular Neuroscience, 2022 N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated cation channels that mediate excitatory neurotransmission and are critical for synaptic development and plasticity in the mammalian central nervous system (CNS). Functional NMDARs typically form
Taylor M. Benske +2 more
doaj +1 more source
Mitochondrial Protein Quality Control Mechanisms
Genes, 2020 Mitochondria serve as a hub for many cellular processes, including bioenergetics, metabolism, cellular signaling, redox balance, calcium homeostasis, and cell death.
P. Jadiya, Dhanendra Tomar
semanticscholar +1 more source
The nucleolus functions as a phase-separated protein quality control compartment
Science, 2019 Phasing-in quality control in the nucleus The fundamental process of protein quality control in the nucleus is not well understood. The nucleus contains several non–membrane-bound subcompartments forming liquid-like condensates.
F. Frottin +9 more
semanticscholar +1 more source
ALS and FTD: where RNA metabolism meets protein quality control.
Seminars in Cell and Developmental Biology, 2020 Recent genetic and biochemical evidence has improved our understanding of the pathomechanisms that lead to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating neurodegenerative diseases with overlapping symptoms and ...
J. Mandrioli +3 more
semanticscholar +1 more source
An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes [PDF]
, 2009 Nuclear mRNA export is a crucial step in eukaryotic gene expression, which is in yeast coupled to cotranscriptional messenger ribonucleoprotein particle ( mRNP) assembly and surveillance.
Attila Rácz +17 more
core +1 more source
Combining high-protein ingredients from pseudocereals and legumes for the development of fresh high-protein hybrid pasta: Maintained technological quality and adequate sensory attributes [PDF]
, 2020 The fortification of cereal foods, like pasta, with pseudocereal and legume ingredients promises a substantial improvement of their nutritional quality.
Arendt, Elke K. +10 more
core +2 more sources
Protein Quality Control at the Mitochondrial Surface
Frontiers in Cell and Developmental Biology, 2021 Mitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of ...
Fabian den Brave +2 more
doaj +1 more source
Protein quality in wheat [PDF]
, 2004 The overall objective of the present studies was to increase the understanding about protein quality in wheat, i.e. to make it possible to improve the production of wheat with desired quality for different end-uses.
Kuktaite, Ramune
core +1 more source
Nature Cell Biology, 2020 Stem cells need to be protected from genotoxic and proteotoxic stress to maintain a healthy pool throughout life1–3. Little is known about the proteostasis mechanism that safeguards stem cells. Here we report endoplasmic reticulum-associated degradation (
Longyong Xu +26 more
semanticscholar +1 more source