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Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases [PDF]
Cells, 2020 Protein homeostasis (proteostasis) disturbances and inflammation are evident in normal aging and some age-related neurodegenerative diseases. While the proteostasis network maintains the integrity of intracellular and extracellular functional proteins ...
Tuuli-Maria Sonninen +4 more
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Regulation of the proteostasis network by the neuronal system [PDF]
Frontiers in Molecular Biosciences, 2023 The protein homeostasis (proteostasis) network is a nexus of molecular mechanisms that act in concert to maintain the integrity of the proteome and ensure proper cellular and organismal functionality.
Huadong Zhu, Ehud Cohen
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The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics. [PDF]
PLoS BiologyProteostasis is essential for cellular health, with its disruption contributing to aging, neurodegeneration, and metabolic disorders. While the upstream proteotoxic stress-sensing and protein-folding mechanisms in the ER and cytosol are well studied, the
Syeda Kubra +15 more
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Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
Cells, 2018 Due to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions.
Jin Li, Bianca J J M Brundel, Deli Zhang
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The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury
Cells, 2022 Proteostasis (protein homeostasis) is critical for cellular as well as organismal survival. It is strictly regulated by multiple conserved pathways including the ubiquitin-proteasome system, autophagy, the heat shock response, the integrated stress ...
Scott R. Whittemore +4 more
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dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
Disease Models & Mechanisms, 2021 Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng +8 more
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Protein homeostasis in aging and cancer
Frontiers in Cell and Developmental Biology, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and
Xiao-Qiong Chen +5 more
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A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease
Cell Reports, 2014 Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, and ...
Marc Brehme +11 more
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Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges
Cells, 2019 : Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows ...
Daria Sicari, Aeid Igbaria, Eric Chevet
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Frontiers in Cell and Developmental Biology, 2021 Several studies reported that mitochondrial stress induces cytosolic proteostasis. How mitochondrial stress activates proteostasis in the cytosol remains unclear.
Edmund Charles Jenkins +2 more
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