Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities? [PDF]
Frontiers in Molecular Neuroscience, 2017 Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells.
Pamela J. Shaw +3 more
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The proteostasis network and its decline in ageing
Nature Reviews Molecular Cell Biology, 2019 Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Mark S Hipp +2 more
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Sirt1 coordinates the mitochondrial UPR and myocellular proteostasis to preserve muscle integrity during muscle atrophy in zebrafish [PDF]
Frontiers in Cell and Developmental BiologyIntroductionThe decline of mitochondrial homeostasis and proteostasis, the two key cell quality control mechanisms, is the hallmark of aging and age-related diseases.
Qing Chen +6 more
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Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
Cells, 2018 Due to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions.
Jin Li +2 more
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Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity [PDF]
eLifePharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically diverse protein misfolding diseases.
Gabriel M Kline +10 more
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The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury
Cells, 2022 Proteostasis (protein homeostasis) is critical for cellular as well as organismal survival. It is strictly regulated by multiple conserved pathways including the ubiquitin-proteasome system, autophagy, the heat shock response, the integrated stress ...
Scott R. Whittemore +4 more
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dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
Disease Models & Mechanisms, 2021 Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng +8 more
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Protein homeostasis in aging and cancer
Frontiers in Cell and Developmental Biology, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and
Xiao-Qiong Chen +5 more
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Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
Cells, 2020 Protein homeostasis (proteostasis) disturbances and inflammation are evident in normal aging and some age-related neurodegenerative diseases. While the proteostasis network maintains the integrity of intracellular and extracellular functional proteins ...
Tuuli-Maria Sonninen +4 more
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Regulation of the proteostasis network by the neuronal system
Frontiers in Molecular Biosciences, 2023 The protein homeostasis (proteostasis) network is a nexus of molecular mechanisms that act in concert to maintain the integrity of the proteome and ensure proper cellular and organismal functionality.
Huadong Zhu, Ehud Cohen
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