Results 1 to 10 of about 48,911 (292)

Determining the effects of nanoparticulate air pollution on proteostasis in Caenorhabditis elegans.

PLoS ONE, 2020
The proteostasis network comprises the biochemical pathways that together maintain and regulate proper protein synthesis, transport, folding, and degradation.
Emily H Green, Elise A Kikis
doaj   +1 more source

Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging

Frontiers in Physiology, 2023
Aging results in a decline of cellular proteostasis capacity which culminates in the accumulation of phototoxic material, causing the onset of age-related maladies and ultimately cell death.
Patricija van Oosten-Hawle
doaj   +1 more source

Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases

Cells, 2018
Due to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions.
Jin Li, Deli Zhang, Marit Wiersma, Bianca J. J. M. Brundel   +3 more
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Dietary-Induced Signals That Activate the Gonadal Longevity Pathway during Development Regulate a Proteostasis Switch in Caenorhabditis elegans Adulthood

Frontiers in Molecular Neuroscience, 2017
Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis).
Netta Shemesh, Lana Meshnik, Nufar Shpigel, Anat Ben-Zvi   +3 more
doaj   +1 more source

Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging

Cell Reports: Methods
Summary: Loss of proteostasis is a hallmark of aging that underlies many age-related diseases. Different cell compartments experience distinctive challenges in maintaining protein quality control, but how aging regulates subcellular proteostasis remains ...
Michelle Curley, Mamta Rai, Chia-Lung Chuang, Vishwajeeth Pagala, Anna Stephan, Zane Coleman, Maricela Robles-Murguia, Yong-Dong Wang, Junmin Peng, Fabio Demontis   +9 more
doaj   +1 more source

Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity

Nature Communications
Polymers can facilitate detergent-free extraction of membrane proteins into nanodiscs (e.g., SMALPs, DIBMALPs), incorporating both integral membrane proteins as well as co-extracted native membrane lipids.
Henry Sawczyc, Takashi Tatsuta, Carl Öster, Spyridon Kosteletos, Sascha Lange, Claudia Bohg, Thomas Langer, Adam Lange   +7 more
doaj   +1 more source

Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.

PLoS ONE, 2013
Disturbed proteostasis as a particular phenotype of the aging organism has been advanced in C. elegans experiments and is also conceived to underlie neurodegenerative diseases in humans.
Philipp Ottis, Bianca Topic, Maarten Loos, Ka Wan Li, Angelica de Souza, Daniela Schulz, August B Smit, Joseph P Huston, Carsten Korth   +8 more
doaj   +1 more source

Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart

Frontiers in Cardiovascular Medicine, 2020
The integrity of the proteome in cardiac myocytes is critical for robust heart function. Proteome integrity in all cells is managed by protein homeostasis or proteostasis, which encompasses processes that maintain the balance of protein synthesis ...
Adrian Arrieta, Erik A. Blackwood, Winston T. Stauffer, Christopher C. Glembotski   +3 more
doaj   +1 more source

The Nuclear Lamina: Protein Accumulation and Disease

Biomedicines, 2020
Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Carla Almendáriz-Palacios, Zoe E. Gillespie, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, Troy A. A. Harkness, Darrell D. Mousseau, Christopher H. Eskiw   +7 more
doaj   +1 more source

Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C. elegans

Cells, 2018
Proteostasis is of vital importance for cellular function and it is challenged upon exposure to acute or chronic insults during neurodegeneration and aging.
Andreas Kern, Natalie Spang, Heike Huesmann, Christian Behl   +3 more
doaj   +1 more source