Role of Protein Misfolding and Proteostasis Deficiency in Protein Misfolding Diseases and Aging [PDF]
International Journal of Cell Biology, 2013 The misfolding, aggregation, and tissue accumulation of proteins are common events in diverse chronic diseases, known as protein misfolding disorders.
Karina Cuanalo-Contreras +2 more
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Intra-FCY1: a novel system to identify mutations that cause protein misfolding [PDF]
Frontiers in Genetics, 2023 Protein misfolding is a common intracellular occurrence. Most mutations to coding sequences increase the propensity of the encoded protein to misfold. These misfolded molecules can have devastating effects on cells.
N. Quan +4 more
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Protein Misfolding and Human Disease [PDF]
The Scientific World Journal, 2002 Protein folding is perhaps the most fundamental process associated with the generation of functional structures in biology. There has been considerable progress in the last few years in understanding the underlying principles that govern this highly complex process.
Christopher Dobson
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Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights [PDF]
BiomedicinesProtein functionality depends on its proper folding, making protein misfolding crucial for the function of proteins and, by extension, cells and the whole organism.
Ouliana Ivantsik +4 more
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Protein Misfolding and Neurodegenerative Diseases [PDF]
International Journal of Cell Biology, 2014 This special issue includes fifteen reviews and two original research articles by leading scientists in the fields of neuropathology, biochemistry, and cell biology, dealing with the role of protein aggregation and prion-like propagation of protein misfolding in neurodegenerative diseases.
Alessio Cardinale +2 more
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Protein Folding and Misfolding on Surfaces [PDF]
International Journal of Molecular Sciences, 2008 Protein folding, misfolding and aggregation, as well as the way misfolded and aggregated proteins affects cell viability are emerging as key themes in molecular and structural biology and in molecular medicine. Recent advances in the knowledge of the biophysical basis of protein folding have led to propose the energy landscape theory which provides a ...
Massimo Stefani
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Impact of translational error‐induced and error‐free misfolding on the rate of protein evolution
Molecular Systems Biology, 2010 What determines the rate of protein evolution is a fundamental question in biology. Recent genomic studies revealed a surprisingly strong anticorrelation between the expression level of a protein and its rate of sequence evolution.
Jian‐Rong Yang +2 more
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A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality [PDF]
Nature CommunicationsProtein misfolding involving changes in non-covalent lasso entanglement (NCLE) status has been proposed based on simulations and biochemical assays of a small number of proteins.
Ian Sitarik +5 more
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Protein misfolding and mitochondrial dysfunction in glaucoma [PDF]
Frontiers in Cell and Developmental BiologyGlaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular pressure caused by restricted outflow of the aqueous humor leads to the degeneration of retinal ganglion cells (RGCs) and their axons.
Arunkumar Venkatesan +2 more
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The Role of Protein S-Nitrosylation in Protein Misfolding-Associated Diseases
Life, 2021 Abnormal and excessive nitrosative stress contributes to neurodegenerative disease associated with the production of pathological levels of misfolded proteins.
Yun-Jin Ju +3 more
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