Results 1 to 10 of about 3,647,798 (263)

Intra-FCY1: a novel system to identify mutations that cause protein misfolding [PDF]

Frontiers in Genetics, 2023
Protein misfolding is a common intracellular occurrence. Most mutations to coding sequences increase the propensity of the encoded protein to misfold. These misfolded molecules can have devastating effects on cells.
N. Quan, N. Quan, Y. Eguchi, K. Geiler-Samerotte, K. Geiler-Samerotte   +4 more
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Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights [PDF]

Biomedicines
Protein functionality depends on its proper folding, making protein misfolding crucial for the function of proteins and, by extension, cells and the whole organism.
Ouliana Ivantsik, Themis P. Exarchos, Aristidis G. Vrahatis, Panagiotis Vlamos, Marios G. Krokidis   +4 more
doaj   +2 more sources

A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality [PDF]

Nature Communications
Protein misfolding involving changes in non-covalent lasso entanglement (NCLE) status has been proposed based on simulations and biochemical assays of a small number of proteins.
Ian Sitarik, Quyen V. Vu, Justin Petucci, Paulina Frutos, Hyebin Song, Edward P. O’Brien   +5 more
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Protein misfolding and mitochondrial dysfunction in glaucoma [PDF]

Frontiers in Cell and Developmental Biology
Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular pressure caused by restricted outflow of the aqueous humor leads to the degeneration of retinal ganglion cells (RGCs) and their axons.
Arunkumar Venkatesan, Audrey M. Bernstein, Audrey M. Bernstein   +2 more
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C-reactive protein: the nexus between inflammation and protein misfolding diseases [PDF]

Frontiers in Immunology
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy, Abhishek Roy, Johannes Zeller, Johannes Zeller, Tracy L. Nero, Tracy L. Nero, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, Michael W. Parker, Michael W. Parker, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +19 more
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A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

Communications Biology, 2021
Cataldi et al. investigates the impact of the dopamine derivative DOPAL on the Aβ peptide oligomer formation. They report that DOPAL promotes the formation of stable Aβ oligomers that exert toxicity on neuroblastoma cells by increasing cytosolic calcium ...
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco S. Ruggeri, Catherine K. Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R. Kumita, Sara Linse, Johnny Habchi, Tuomas P. J. Knowles, Benedetta Mannini, Christopher M. Dobson, Michele Vendruscolo   +15 more
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Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

Communications Biology, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01680 ...
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco S. Ruggeri, Catherine K. Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R. Kumita, Sara Linse, Johnny Habchi, Tuomas P. J. Knowles, Benedetta Mannini, Christopher M. Dobson, Michele Vendruscolo   +15 more
doaj   +1 more source

Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1

Antioxidants, 2022
Cells that experience high levels of oxidative stress respond by inducing antioxidant proteins through activation of the protein transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2).
Vy Ngo, Nadun C. Karunatilleke, Anne Brickenden, Wing-Yiu Choy, Martin L. Duennwald   +4 more
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Insights from nature: A review of natural compounds that target protein misfolding in vivo

Current Research in Biotechnology, 2020
Protein misfolding is fundamental to a number of human disorders including Alzheimer’s disease, prion diseases, Parkinson’s disease and type 2 diabetes mellitus. To date, there are still no cures for protein misfolding disorders.
Cassandra Terry
doaj   +1 more source

Molecular and Cellular Basis of Misfolded Proteins in Neurodegenerative Diseases [PDF]

International Clinical Neuroscience Journal, 2022
Background: Neurodegeneration is characterized by a progressive loss of nerve structure and function which lead to cognitive impairment such as dementia.
Alireza Zali, Saeid Safari, Sara Rahmati Roodsari, Somayeh Niknazar   +3 more
doaj   +1 more source