Results 41 to 50 of about 53,939 (158)

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

Cell Reports, 2016
Summary: Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the ...
Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin   +15 more
doaj   +1 more source

(Dis)Solving the problem of aberrant protein states

Disease Models & Mechanisms, 2021
Neurodegenerative diseases and other protein-misfolding disorders represent a longstanding biomedical challenge, and effective therapies remain largely elusive.
Charlotte M. Fare, James Shorter
doaj   +1 more source

A hydrophobic gold surface triggers misfolding and aggregation of the amyloidogenic Josephin domain in monomeric form, while leaving the oligomers unaffected.

PLoS ONE, 2013
Protein misfolding and aggregation in intracellular and extracellular spaces is regarded as a main marker of the presence of degenerative disorders such as amyloidoses.
Alessandra Apicella, Monica Soncini, Marco Agostino Deriu, Antonino Natalello, Marcella Bonanomi, David Dellasega, Paolo Tortora, Maria Elena Regonesi, Carlo Spartaco Casari   +8 more
doaj   +1 more source

Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial CellsSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & aims: Gastroesophageal reflux disease (GERD) is a common digestive disorder that is characterized by esophageal tissue damage produced by exposure of the esophageal lining to the gastric refluxate.
Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Wael El-Rifai, Zhibin Chen, Jianwen Que, Timothy C. Wang, Olivier G. Boutaud, Karoline Briegel, Sergey I. Dikalov, Monica T. Garcia-Buitrago, Alexander I. Zaika   +10 more
doaj   +1 more source

Proteostasis Response to Protein Misfolding in Controlled Hypertension

Cells, 2022
Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira, Dário Trindade, Marisol Gouveia, Roberta Eller-Borges, Sandra Magalhães, Ana Duarte, Miriam Ferreira, Maria I. Simões, Maria Conceição, Alexandra Nunes, Ana Gabriela Henriques, Fernando Ribeiro, Sandra I. Vieira   +12 more
doaj   +1 more source

Na+/K+-ATPase is present in scrapie-associated fibrils, modulates PrP misfolding in vitro and links PrP function and dysfunction.

PLoS ONE, 2011
Transmissible spongiform encephalopathies are characterised by widespread deposition of fibrillar and/or plaque-like forms of the prion protein. These aggregated forms are produced by misfolding of the normal prion protein, PrP(C), to the disease ...
James F Graham, Dominic Kurian, Sonya Agarwal, Lorna Toovey, Lawrence Hunt, Louise Kirby, Teresa J T Pinheiro, Steven J Banner, Andrew C Gill   +8 more
doaj   +1 more source

The Role of Protein S-Nitrosylation in Protein Misfolding-Associated Diseases

Life, 2021
Abnormal and excessive nitrosative stress contributes to neurodegenerative disease associated with the production of pathological levels of misfolded proteins.
Yun-Jin Ju, Hye-Won Lee, Ji-Woong Choi, Min-Sik Choi   +3 more
doaj   +1 more source

Protein Misfolding and Retinal Degeneration [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
The retina is a highly complex and specialized organ that performs preliminary analysis of visual information. Composed of highly metabolically active tissue, the retina requires a precise and well-balanced means of maintaining its functional activity during extended periods of time.
Radouil, Tzekov, Linda, Stein, Shalesh, Kaushal   +2 more
openaire   +2 more sources

From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis

Neurobiology of Disease, 2015
Prions, self-proliferating infectious agents consisting of misfolded protein, are most often associated with aggressive neurodegenerative diseases in animals and humans.
Leslie I. Grad, Sarah M. Fernando, Neil R. Cashman   +2 more
doaj   +1 more source

Autophagy and misfolded proteins in neurodegeneration

Experimental Neurology, 2012
The accumulation of misfolded proteins in insoluble aggregates within the neuronal cytoplasm is one of the common pathological hallmarks of most adult-onset human neurodegenerative diseases. The clearance of these misfolded proteins may represent a promising therapeutic strategy in these diseases.
Metcalf, Daniel J., García-Arencibia, Moisés, Hochfeld, Warren E., Rubinsztein, David C.   +3 more
openaire   +3 more sources