Results 51 to 60 of about 53,939 (158)
Brazilian Journal of Medical and Biological Research, 2005 In the last few years, hydrostatic pressure has been extensively used in the study of both protein folding and misfolding/aggregation. Compared to other chemical or physical denaturing agents, a unique feature of pressure is its ability to induce subtle ...
S.T. Ferreira +2 more
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Frontiers in Molecular Neuroscience, 2018 Protein quality control (PQC) is critical to maintain a functioning proteome. Misfolded or toxic proteins are either refolded or degraded by a system of temporal quality control and can also be sequestered into aggregates or inclusions by a system of ...
Kara L. Schneider +2 more
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Biomolecules, 2020 Many devastating neurodegenerative diseases are driven by the misfolding of normal proteins into a pathogenic abnormal conformation. Examples of such protein misfolding diseases include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease ...
Cristóbal Marrero-Winkens +2 more
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The VES hypothesis and protein misfolding
Discrete and Continuous Dynamical Systems - S, 2011 Proteins function by changing conformation. These conformational changes, which involve the concerted motion of a large number of atoms are classical events but, in many cases, the triggers are quantum mechanical events such as chemical reactions. Here the initial quantum states after the chemical reaction are assumed to be vibrational excited states ...
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The different axes of the mammalian mitochondrial unfolded protein response
BMC Biology, 2018 Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs). Of particular recent interest has been the mitochondrial unfolded protein response (UPRmt), activated to restore protein
Christian Münch
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Frontiers in Molecular Neuroscience, 2017 Heat shock proteins (Hsps) are ubiquitously expressed chaperone proteins that enable cells to cope with environmental stresses that cause misfolding and denaturation of proteins.
Bernadett Kalmar +2 more
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Disulfide Bonding in Neurodegenerative Misfolding Diseases
International Journal of Cell Biology, 2013 In recent years an increasing number of neurodegenerative diseases has been linked to the misfolding of a specific protein and its subsequent accumulation into aggregated species, often toxic to the cell.
Maria Francesca Mossuto
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Modulating protein quality control
eLife, 2016 Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
Lars Plate +3 more
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Protein misfolding disorders and macroautophagy
Current Opinion in Cell Biology, 2011 A large group of diseases, termed protein misfolding disorders, share the common feature of the accumulation of misfolded proteins. The possibility of a common mechanism underlying either the pathogenesis or therapy for these diseases is appealing. Thus, there is great interest in the role of protein degradation via autophagy in such conditions where ...
Menzies, Fiona M +2 more
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Applied SciencesProtein misfolding and aggregation represent key pathological mechanisms in neurodegenerative and systemic amyloid disorders, yet disease-modifying therapeutic strategies remain limited.
Corina Dalia Toderescu +5 more
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