Results 31 to 40 of about 3,647,798 (263)
Divergent effects of PERK and IRE1 signaling on cell viability.
PLoS ONE, 2009 Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling pathways, collectively termed the Unfolded Protein Response (UPR). UPR signaling promotes cell survival by reducing misfolded protein levels.
Jonathan H Lin +4 more
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Matrin3: Disorder and ALS Pathogenesis
Frontiers in Molecular Biosciences, 2022 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of both upper and lower motor neurons in the brain and spinal cord.
Ahmed Salem +7 more
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Bridging the gap: From protein misfolding to protein misfolding diseases
FEBS Letters, 2009 Protein misfolding and aggregation are pathognomic for a number of the most common age‐related degenerative diseases. Great progress has been made in studying protein aggregation in the test tube and also in replicating protein aggregation in vertebrate animal models of these diseases.
Luheshi, Leila M. +1 more
openaire +2 more sources
Stress and viral insults do not trigger E200K PrP conversion in human cerebral organoids.
PLoS ONE, 2022 Prion diseases are a group of rare, transmissible, and invariably fatal neurodegenerative diseases that affect both humans and animals. The cause of these diseases is misfolding of the prion protein into pathological isoforms called prions.
Anna Smith +9 more
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A Review on Protein Misfolding Diseases and therapeutics for preventing Diseases [PDF]
, 2021 Background: Protein misfolding sicknesses are the gathering of irresistible lethal neuro and non-neurodegenerative infections and in ebb and flow researchers and specialists accepted that unusual folding of protein is the essential or main key of such ...
Singh, Yogesh Kumar, Yogesh Kumar Singh
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Protein misfolding and cellular stress in disease and ageing - Concepts and protocols
European Journal of Histochemistry, 2011 To those readers that already got the Protein misfolding and disease volume, this new title can sound as an update or a second edition of the previous volume: well, this is not the case.
Carlo Alberto Redi
doaj +1 more source
Theoretical model of prion propagation: A misfolded protein induces misfolding [PDF]
Proceedings of the National Academy of Sciences, 2005 There is a hypothesis that dangerous diseases such as bovine spongiform encephalopathy, Creutzfeldt-Jakob, Alzheimer's, fatal familial insomnia, and several others are induced by propagation of wrong or misfolded conformations of some vital proteins. If for some reason the misfolded conformations were acquired by many such protein molecules it might ...
Edyta, Małolepsza +3 more
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Scientific Reports, 2021 Misfolding of the cellular prion protein, PrPC, into the amyloidogenic isoform, PrPSc, which forms infectious protein aggregates, the so-called prions, is a key pathogenic event in prion diseases.
Hideyuki Hara +6 more
doaj +1 more source
Protein Misfolding and Retinal Degeneration [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 The retina is a highly complex and specialized organ that performs preliminary analysis of visual information. Composed of highly metabolically active tissue, the retina requires a precise and well-balanced means of maintaining its functional activity during extended periods of time.
Radouil, Tzekov +2 more
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Outline and computational approaches of protein misfolding.
, 2010 Protein misfolding is a general causation of classical conformational diseases and many pathogenic changes that are the result of structural conversion.
刘鑫
core +2 more sources