Results 41 to 50 of about 48,911 (292)
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
Frontiers in Molecular Neuroscience, 2017 Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells.
Pamela J. Shaw +3 more
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Insights Into the Links Between Proteostasis and Aging From C. elegans
Frontiers in Aging, 2022 Protein homeostasis (proteostasis) is maintained by a tightly regulated and interconnected network of biological pathways, preventing the accumulation and aggregation of damaged or misfolded proteins. Thus, the proteostasis network is essential to ensure
William Hongyu Zhang +4 more
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Divergent Modulation of Proteostasis in Prostate Cancer
, 2020 Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. the mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significantly ...
Erbaykent-Tepedelen, Burcu +7 more
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Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
Nature Communications, 2017 Seeding of amyloid beta from one brain region to another is thought to contribute to the progression of Alzheimer’s disease, although to date most studies have depended on inoculation of animals with exogenous amyloid. Here the authors describe a genetic
Ramona F. Sowade, Thomas R. Jahn
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Quality Control of Mitochondrial Proteostasis [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 A decline in mitochondrial activity has been associated with aging and is a hallmark of many neurological diseases. Surveillance mechanisms acting at the molecular, organellar, and cellular level monitor mitochondrial integrity and ensure the maintenance of mitochondrial proteostasis. Here we will review the central role of mitochondrial chaperones and
Baker, M., Tatsuta, T., Langer, T.
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Proteostasis in pediatric pulmonary pathology [PDF]
, 2014 Protein homeostasis describes the tight supervision of protein synthesis, correct protein maturation and folding, as well as the timely disposal of unwanted and damaged proteins by the ubiquitin-proteasome pathway or the lysosome-autophagy route.
Korbinian Ballweg +3 more
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Frontiers in Cell and Developmental Biology, 2021 For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability.
Shenae L. Cafe +7 more
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BMC Biology, 2020 Background The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function.
Lena Maria Murschall +7 more
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PLoS Biology, 2022 The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes.
Jimin Yoon +12 more
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Chemical Biology Framework to Illuminate Proteostasis
, 2021 © 2020 Annual Reviews Inc.. All rights reserved. Protein folding in the cell is mediated by an extensive network of >1,000 chaperones, quality control factors, and trafficking mechanisms collectively termed the proteostasis network.
Sebastian, Rebecca M. +3 more
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