Results 41 to 50 of about 57,493 (305)
Molecular Glue Degraders and the Expanding Design Space of Drug Discovery
CHIMIASmall-molecule drug discovery has long centered on inhibiting protein function through high-affinity binding to defined active sites. An emerging alternative shifts the focus from inhibition to rewiring - modulating protein-protein interactions within ...
Zuzanna Kozicka
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Neural Plasticity, 2018 Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with ...
Pablo Olivero +8 more
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Unravelling druggable signalling networks that control F508del-CFTR proteostasis
eLife, 2015 Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein.
Ramanath Narayana Hegde +15 more
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The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]
, 2017 One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A. +32 more
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Quality Control of Mitochondrial Proteostasis [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 A decline in mitochondrial activity has been associated with aging and is a hallmark of many neurological diseases. Surveillance mechanisms acting at the molecular, organellar, and cellular level monitor mitochondrial integrity and ensure the maintenance of mitochondrial proteostasis. Here we will review the central role of mitochondrial chaperones and
Baker, M., Tatsuta, T., Langer, T.
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Fluorodeoxyuridine improves Caenorhabditis elegans proteostasis independent of reproduction onset. [PDF]
PLoS ONE, 2014 Protein homeostasis (proteostasis) networks are dynamic throughout the lifespan of an organism. During Caenorhabditis elegans adulthood, the maintenance of metastable proteins and the activation of stress responses are inversely associated with germline ...
Naama Feldman +2 more
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Cells, 2022 Proteostasis, a portmanteau of the words protein and homeostasis, refers to the ability of eukaryotic cells to maintain a stable proteome by acting on protein synthesis, quality control and/or degradation.
Jonas Johannes Papendorf +2 more
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Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis. [PDF]
, 2020 Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis.
Cuevas-Mora, Karina +2 more
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The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
Cells, 2018 In normal physiological condition, the maintenance of cellular proteostasis is a prerequisite for cell growth, functioning, adapting to changing micro-environments, and responding to extracellular stress.
Zhen Dong, Hongjuan Cui
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Cell aging preserves cellular immortality in the presence of lethal levels of damage. [PDF]
, 2019 Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells.
Chao, Lin +4 more
core +3 more sources