Results 41 to 50 of about 51,687 (291)
Proteostasis in pediatric pulmonary pathology [PDF]
, 2014 Protein homeostasis describes the tight supervision of protein synthesis, correct protein maturation and folding, as well as the timely disposal of unwanted and damaged proteins by the ubiquitin-proteasome pathway or the lysosome-autophagy route.
Korbinian Ballweg +3 more
core +1 more source
PLoS Biology, 2022 The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes.
Jimin Yoon +12 more
doaj +1 more source
The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
Cells, 2018 In normal physiological condition, the maintenance of cellular proteostasis is a prerequisite for cell growth, functioning, adapting to changing micro-environments, and responding to extracellular stress.
Zhen Dong, Hongjuan Cui
doaj +1 more source
Linking cellular proteostasis to yeast longevity [PDF]
, 2018 Proteostasis is a cellular housekeeping process that refers to the healthy maintenance of the cellular proteome that governs the fate of proteins from synthesis to degradation.
Marques, Maria Belém Sousa Sampaio +3 more
core +1 more source
Proteostasis in T cell aging [PDF]
, 2023 Aging leads to a decline in immune cell function, which leaves the organism vulnerable to infections and age-related multimorbidities. One major player of the adaptive immune response are T cells, and recent studies argue for a major role of disturbed ...
Leng, Houfu +11 more
core +1 more source
Cell Reports, 2013 The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6.
Matthew D. Shoulders +9 more
doaj +1 more source
Proteostasis in complex dendrites
Nature Reviews Neuroscience, 2013 Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a unique multipolar architecture that makes ∼10,000 synaptic contacts with other neurons. Both the stability and modifiability of the neuronal proteome are crucial for its information-processing, storage ...
Cyril Hanus, Erin M. Schuman
openaire +3 more sources
Molecular Glue Degraders and the Expanding Design Space of Drug Discovery
CHIMIASmall-molecule drug discovery has long centered on inhibiting protein function through high-affinity binding to defined active sites. An emerging alternative shifts the focus from inhibition to rewiring - modulating protein-protein interactions within ...
Zuzanna Kozicka
doaj +1 more source
Endoplasmic reticulum and Golgi stress signaling-mediated regulation of protein secretion
Cellular & Molecular Biology LettersThe eukaryotic secretory pathway (SP) is essential to ensure cellular functions and multicellular communication. The early SP is constituted mostly of the endoplasmic reticulum (ER), the ER–Golgi intermediate compartment (ERGIC), and the Golgi apparatus.
Ketsia Bakambamba +5 more
doaj +1 more source
Neural Plasticity, 2018 Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with ...
Pablo Olivero +8 more
doaj +1 more source