Results 41 to 50 of about 43,964 (292)

Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo

Nature Communications, 2017
Seeding of amyloid beta from one brain region to another is thought to contribute to the progression of Alzheimer’s disease, although to date most studies have depended on inoculation of animals with exogenous amyloid. Here the authors describe a genetic
Ramona F. Sowade, Thomas R. Jahn
doaj   +1 more source

Quality Control of Mitochondrial Proteostasis [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
A decline in mitochondrial activity has been associated with aging and is a hallmark of many neurological diseases. Surveillance mechanisms acting at the molecular, organellar, and cellular level monitor mitochondrial integrity and ensure the maintenance of mitochondrial proteostasis. Here we will review the central role of mitochondrial chaperones and
Baker, M., Tatsuta, T., Langer, T.
openaire   +3 more sources

Chemical Biology Framework to Illuminate Proteostasis

, 2021
© 2020 Annual Reviews Inc.. All rights reserved. Protein folding in the cell is mediated by an extensive network of >1,000 chaperones, quality control factors, and trafficking mechanisms collectively termed the proteostasis network.
Sebastian, Rebecca M., Sebastian, Rebecca M, Shoulders, Matthew D., Shoulders, Matthew D   +3 more
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The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope.

PLoS Biology, 2022
The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes.
Jimin Yoon, Emmanuel E Nekongo, Jessica E Patrick, Tiffani Hui, Angela M Phillips, Anna I Ponomarenko, Samuel J Hendel, Rebecca M Sebastian, Yu Meng Zhang, Vincent L Butty, C Brandon Ogbunugafor, Yu-Shan Lin, Matthew D Shoulders   +12 more
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Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

Cell Reports, 2013
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6.
Matthew D. Shoulders, Lisa M. Ryno, Joseph C. Genereux, James J. Moresco, Patricia G. Tu, Chunlei Wu, John R. Yates, III, Andrew I. Su, Jeffery W. Kelly, R. Luke Wiseman   +9 more
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Hematopoietic stem cell regulation by the proteostasis network [PDF]

, 2020
Purpose of reviewProtein homeostasis (proteostasis) is maintained by an integrated network of physiological mechanisms and stress response pathways that regulate the content and quality of the proteome.
Signer, Robert AJ, Bernadette A. Chua, Chua, Bernadette A, Robert A.J. Signer   +3 more
core   +1 more source

The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import

BMC Biology, 2020
Background The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function.
Lena Maria Murschall, Anne Gerhards, Thomas MacVicar, Esra Peker, Lidwina Hasberg, Stephan Wawra, Thomas Langer, Jan Riemer   +7 more
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Linking cellular proteostasis to yeast longevity [PDF]

, 2018
Proteostasis is a cellular housekeeping process that refers to the healthy maintenance of the cellular proteome that governs the fate of proteins from synthesis to degradation.
Marques, Maria Belém Sousa Sampaio, Paula Ludovico, Ludovico, Paula, Belém Sampaio-Marques   +3 more
core   +1 more source

Proteostasis in complex dendrites

Nature Reviews Neuroscience, 2013
Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a unique multipolar architecture that makes ∼10,000 synaptic contacts with other neurons. Both the stability and modifiability of the neuronal proteome are crucial for its information-processing, storage ...
Cyril Hanus, Erin M. Schuman
openaire   +3 more sources

Proteostasis Response to Protein Misfolding in Controlled Hypertension

Cells, 2022
Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira, Dário Trindade, Marisol Gouveia, Roberta Eller-Borges, Sandra Magalhães, Ana Duarte, Miriam Ferreira, Maria I. Simões, Maria Conceição, Alexandra Nunes, Ana Gabriela Henriques, Fernando Ribeiro, Sandra I. Vieira   +12 more
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