Results 31 to 40 of about 48,911 (292)

Hyperammonemia and proteostasis in cirrhosis [PDF]

Current Opinion in Clinical Nutrition & Metabolic Care, 2018
Skeletal muscle loss or sarcopenia is a frequent complication of cirrhosis that adversely affects clinical outcomes. As skeletal muscle is the largest store of proteins in the body, proteostasis or protein homeostasis is required for maintenance of muscle mass. This review will focus on disordered skeletal muscle proteostasis in liver disease.Increased
Srinivasan, Dasarathy, Maria, Hatzoglou
openaire   +2 more sources

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

Cell Reports, 2014
Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, and ...
Marc Brehme, Cindy Voisine, Thomas Rolland, Shinichiro Wachi, James H. Soper, Yitan Zhu, Kai Orton, Adriana Villella, Dan Garza, Marc Vidal, Hui Ge, Richard I. Morimoto   +11 more
doaj   +1 more source

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]

, 2012
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Kikhney, Alexey, Roermund, Carlo W.T. van,, van Roermund, C. W. T., Opalinski, L., Kikhney, A., Williams, Chris,, de Boer, R., Veenhuis, Marten, Kikhney, Alexey,, de Boer, Rinse, Williams, C., Williams, Chris, Opalinski, Lukasz, Bartoszewska, M., Klei, Ida J. van der,, van der Klei, Ida J., Boer, Rinse de,, Opaliński, Łukasz,, van der Klei, I. J., van Roermund, Carlo W. T., Veenhuis, Marten,, Veenhuis, M., van der Klei, Ida J.; id_orcid, Bartoszewska, Magdalena, Bartoszewska, Magdalena,   +24 more
core   +3 more sources

Regulation of the proteostasis network by the neuronal system

Frontiers in Molecular Biosciences, 2023
The protein homeostasis (proteostasis) network is a nexus of molecular mechanisms that act in concert to maintain the integrity of the proteome and ensure proper cellular and organismal functionality.
Huadong Zhu, Ehud Cohen
doaj   +1 more source

Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges

Cells, 2019
: Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows ...
Daria Sicari, Aeid Igbaria, Eric Chevet
doaj   +1 more source

Folding Mitochondrial-Mediated Cytosolic Proteostasis Into the Mitochondrial Unfolded Protein Response

Frontiers in Cell and Developmental Biology, 2021
Several studies reported that mitochondrial stress induces cytosolic proteostasis. How mitochondrial stress activates proteostasis in the cytosol remains unclear.
Edmund Charles Jenkins, Mrittika Chattopadhyay, Doris Germain   +2 more
doaj   +1 more source

Proteostasis in T cell aging [PDF]

, 2023
Aging leads to a decline in immune cell function, which leaves the organism vulnerable to infections and age-related multimorbidities. One major player of the adaptive immune response are T cells, and recent studies argue for a major role of disturbed ...
Leng, Houfu, Houfu Leng, Simon, A.K., Simon, Anna, Zinecker, H., Heidi Zinecker, Gressler, A.E., Zinecker, Heidi, A. Elisabeth Gressler, Gressler, A, Anna Katharina Simon, Leng, H.   +11 more
core   +1 more source

CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation

Cell Death and Disease, 2023
Unbalanced protein homeostasis (proteostasis) networks are frequently linked to tumorigenesis, making cancer cells more susceptible to treatments that target proteostasis regulators.
Jian Cheng, Guizhong Zhang, Tian Deng, Zhao Liu, Mengqi Zhang, Pengchao Zhang, Funmilayo O. Adeshakin, Xiangyun Niu, Dehong Yan, Xiaochun Wan, Guang Yu   +10 more
doaj   +1 more source

Synaptic proteostasis in Parkinson's disease

Current Opinion in Neurobiology, 2022
There are over 7 million people worldwide suffering from Parkinson's disease, and this number will double in the next decade. Causative mutations and risk variants in >20 genes that predominantly act at synapses have been linked to Parkinson's disease. Synaptic defects precede neuronal death.
Nachman, Eliana, Verstreken, Patrik
openaire   +2 more sources

Changes in Glutathione Redox Potential Are Linked to Aβ42-Induced Neurotoxicity

Cell Reports, 2018
Summary: Glutathione is the major low-molecular weight thiol of eukaryotic cells. It is central to one of the two major NADPH-dependent reducing systems and is likely to play a role in combating oxidative stress, a process suggested to play a key role in
Zeenna A. Stapper, Thomas R. Jahn
doaj   +1 more source