Results 31 to 40 of about 51,687 (291)
Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
Nature Communications, 2017 Seeding of amyloid beta from one brain region to another is thought to contribute to the progression of Alzheimer’s disease, although to date most studies have depended on inoculation of animals with exogenous amyloid. Here the authors describe a genetic
Ramona F. Sowade, Thomas R. Jahn
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Cell Death and Disease, 2023 Unbalanced protein homeostasis (proteostasis) networks are frequently linked to tumorigenesis, making cancer cells more susceptible to treatments that target proteostasis regulators.
Jian Cheng +10 more
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Insights Into the Links Between Proteostasis and Aging From C. elegans
Frontiers in Aging, 2022 Protein homeostasis (proteostasis) is maintained by a tightly regulated and interconnected network of biological pathways, preventing the accumulation and aggregation of damaged or misfolded proteins. Thus, the proteostasis network is essential to ensure
William Hongyu Zhang +4 more
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Divergent Modulation of Proteostasis in Prostate Cancer
, 2020 Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. the mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significantly ...
Erbaykent-Tepedelen, Burcu +14 more
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Proteostasis During Cerebral Ischemia [PDF]
, 2019 Cerebral ischemic is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation ...
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Quality Control of Mitochondrial Proteostasis [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 A decline in mitochondrial activity has been associated with aging and is a hallmark of many neurological diseases. Surveillance mechanisms acting at the molecular, organellar, and cellular level monitor mitochondrial integrity and ensure the maintenance of mitochondrial proteostasis. Here we will review the central role of mitochondrial chaperones and
Baker, M., Tatsuta, T., Langer, T.
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Extracellular Chaperones and Proteostasis
Annual Review of Biochemistry, 2013 There exists a family of currently untreatable, serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited, but it has significantly advanced with the discovery of a small but ...
Wyatt, Amy R +3 more
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BMC Biology, 2020 Background The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function.
Lena Maria Murschall +7 more
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Frontiers in Cell and Developmental Biology, 2021 For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability.
Shenae L. Cafe +7 more
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PROTEOSTASIS: A European Network to Break Barriers and Integrate Science on Protein Homeostasis
, 2019 Protein homeostasis (proteostasis) is at the core of cellular functions. The European network PROTEOSTASIS was created to steer research and foster collaborations in the interconnected fields of posttranslational modifications by ubiquitin family members
Core, Group Members of PROTEOSTASIS +4 more
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