Results 31 to 40 of about 43,964 (292)
Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges
Cells, 2019 : Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows ...
Daria Sicari, Aeid Igbaria, Eric Chevet
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Frontiers in Cell and Developmental Biology, 2021 Several studies reported that mitochondrial stress induces cytosolic proteostasis. How mitochondrial stress activates proteostasis in the cytosol remains unclear.
Edmund Charles Jenkins +2 more
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Synaptic proteostasis in Parkinson's disease
Current Opinion in Neurobiology, 2022 There are over 7 million people worldwide suffering from Parkinson's disease, and this number will double in the next decade. Causative mutations and risk variants in >20 genes that predominantly act at synapses have been linked to Parkinson's disease. Synaptic defects precede neuronal death.
Nachman, Eliana, Verstreken, Patrik
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Cell Death and Disease, 2023 Unbalanced protein homeostasis (proteostasis) networks are frequently linked to tumorigenesis, making cancer cells more susceptible to treatments that target proteostasis regulators.
Jian Cheng +10 more
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Insights Into the Links Between Proteostasis and Aging From C. elegans
Frontiers in Aging, 2022 Protein homeostasis (proteostasis) is maintained by a tightly regulated and interconnected network of biological pathways, preventing the accumulation and aggregation of damaged or misfolded proteins. Thus, the proteostasis network is essential to ensure
William Hongyu Zhang +4 more
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Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
Frontiers in Molecular Neuroscience, 2017 Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells.
Pamela J. Shaw +3 more
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MicroRNAs as central regulators of adult myogenesis and proteostasis loss in skeletal muscle ageing [PDF]
, 2022 This is an Accepted Manuscript of a book chapter published by CRC Press in [Proteostasis and proteolysis] on [5/11/2021], available online: http://www.crcpress.com/9780367499327Sarcopenia (from the Greek words sarca (σάρκα) = flesh and penia (πενία ...
Kanakis, Ioannis +3 more
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Changes in Glutathione Redox Potential Are Linked to Aβ42-Induced Neurotoxicity
Cell Reports, 2018 Summary: Glutathione is the major low-molecular weight thiol of eukaryotic cells. It is central to one of the two major NADPH-dependent reducing systems and is likely to play a role in combating oxidative stress, a process suggested to play a key role in
Zeenna A. Stapper, Thomas R. Jahn
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Frontiers in Cell and Developmental Biology, 2021 For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability.
Shenae L. Cafe +7 more
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Divergent Modulation of Proteostasis in Prostate Cancer
, 2020 Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. the mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significantly ...
Erbaykent-Tepedelen, Burcu +7 more
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