Results 11 to 20 of about 57,493 (305)
Proteostasis signatures in human diseases.
PLoS Computational BiologyThe protein homeostasis (proteostasis) network maintains the proteome in a functional state. Although this network has been comprehensively mapped, its perturbations in disease remain incompletely characterised.
Christine M Lim, Michele Vendruscolo
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Proteostasis During Cerebral Ischemia [PDF]
Frontiers in Neuroscience, 2019 Cerebral ischemia is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation ...
Audrey M. Thiebaut +6 more
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Proteostasis impairment in ALS [PDF]
Brain Research, 2016 In physiological conditions the maintenance of the cellular proteome is a prerequisite for optimal cell functioning and cell survival. Additionally, cells need to constantly sense and adapt to their changing environment and associated stressors.
Ruegsegger C, Saxena S
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Hyperammonemia and proteostasis in cirrhosis [PDF]
Current Opinion in Clinical Nutrition & Metabolic Care, 2018 Skeletal muscle loss or sarcopenia is a frequent complication of cirrhosis that adversely affects clinical outcomes. As skeletal muscle is the largest store of proteins in the body, proteostasis or protein homeostasis is required for maintenance of muscle mass. This review will focus on disordered skeletal muscle proteostasis in liver disease.Increased
Srinivasan, Dasarathy, Maria, Hatzoglou
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A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease
Cell Reports, 2014 Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, and ...
Marc Brehme +11 more
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Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges
Cells, 2019 : Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows ...
Daria Sicari, Aeid Igbaria, Eric Chevet
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Frontiers in Cell and Developmental Biology, 2021 Several studies reported that mitochondrial stress induces cytosolic proteostasis. How mitochondrial stress activates proteostasis in the cytosol remains unclear.
Edmund Charles Jenkins +2 more
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Biosensors for Studying Neuronal Proteostasis [PDF]
Frontiers in Molecular Neuroscience, 2022 Cellular health depends on the integrity and functionality of the proteome. Each cell is equipped with a protein quality control machinery that maintains protein homeostasis (proteostasis) by helping proteins adopt and keep their native structure, and ensuring the degradation of damaged proteins.
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Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]
, 2016 Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching +7 more
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Cell Death and Disease, 2023 Unbalanced protein homeostasis (proteostasis) networks are frequently linked to tumorigenesis, making cancer cells more susceptible to treatments that target proteostasis regulators.
Jian Cheng +10 more
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