Results 11 to 20 of about 43,964 (292)
Regulation of the proteostasis network by the neuronal system [PDF]
Frontiers in Molecular Biosciences, 2023 The protein homeostasis (proteostasis) network is a nexus of molecular mechanisms that act in concert to maintain the integrity of the proteome and ensure proper cellular and organismal functionality.
Huadong Zhu, Ehud Cohen
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Unravelling druggable signalling networks that control F508del-CFTR proteostasis
eLife, 2015 Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein.
Ramanath Narayana Hegde +15 more
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Sirt1 coordinates the mitochondrial UPR and myocellular proteostasis to preserve muscle integrity during muscle atrophy in zebrafish [PDF]
Frontiers in Cell and Developmental BiologyIntroductionThe decline of mitochondrial homeostasis and proteostasis, the two key cell quality control mechanisms, is the hallmark of aging and age-related diseases.
Qing Chen +6 more
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Proteostasis During Cerebral Ischemia
Frontiers in Neuroscience, 2019 Cerebral ischemia is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation ...
Audrey M. Thiebaut +6 more
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Functional Modules of the Proteostasis Network [PDF]
Cold Spring Harbor Perspectives in Biology, 2019 Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis) and prevent the accumulation of potentially toxic protein aggregates. This proteostasis network (PN) comprises the machineries for the biogenesis, folding, conformational maintenance, and degradation of proteins with molecular chaperones as central ...
Jayaraj GG, Hipp MS, Hartl FU
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Fluorodeoxyuridine improves Caenorhabditis elegans proteostasis independent of reproduction onset. [PDF]
PLoS ONE, 2014 Protein homeostasis (proteostasis) networks are dynamic throughout the lifespan of an organism. During Caenorhabditis elegans adulthood, the maintenance of metastable proteins and the activation of stress responses are inversely associated with germline ...
Naama Feldman +2 more
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Extracellular Chaperones and Proteostasis
Annual Review of Biochemistry, 2013 There exists a family of currently untreatable, serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited, but it has significantly advanced with the discovery of a small but ...
Wyatt, Amy R +3 more
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Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
Cells, 2018 Due to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions.
Jin Li, Deli Zhang, Marit Wiersma
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Proteostasis in Cerebral Small Vessel Disease [PDF]
Frontiers in Neuroscience, 2019 Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combination ...
Christof Haffner
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Modulation of host proteostasis by Prevotella corporis via induction of the heat shock response [PDF]
Cell Stress & ChaperonesNeurodegenerative protein conformational diseases (PCDs) are progressive, currently incurable disorders driven by toxic protein aggregation that leads to neuronal death.
Matthew F. Tibi +8 more
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