Results 11 to 20 of about 51,687 (291)
Proteostasis signatures in human diseases. [PDF]
PLoS Computational BiologyThe protein homeostasis (proteostasis) network maintains the proteome in a functional state. Although this network has been comprehensively mapped, its perturbations in disease remain incompletely characterised.
Christine M Lim, Michele Vendruscolo
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Proteostasis impairment in ALS [PDF]
Brain Research, 2016 In physiological conditions the maintenance of the cellular proteome is a prerequisite for optimal cell functioning and cell survival. Additionally, cells need to constantly sense and adapt to their changing environment and associated stressors.
Ruegsegger C, Saxena S
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Biosensors for Studying Neuronal Proteostasis [PDF]
Frontiers in Molecular Neuroscience, 2022 Cellular health depends on the integrity and functionality of the proteome. Each cell is equipped with a protein quality control machinery that maintains protein homeostasis (proteostasis) by helping proteins adopt and keep their native structure, and ensuring the degradation of damaged proteins.
Dudanova, I., Irina Dudanova
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, 2021 Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.
Niki Chondrogianni +2 more
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Proteostasis impairment and ALS
Progress in Biophysics and Molecular Biology, 2022 Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disease that results from the loss of both upper and lower motor neurons. It is the most common motor neuron disease and currently has no effective treatment. There is mounting evidence to suggest that disturbances in proteostasis play a significant role in ALS ...
Isabella A, Lambert-Smith +2 more
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Proteostasis in thermogenesis and obesity
Biological Chemistry, 2020 AbstractThe proper production, degradation, folding and activity of proteins, proteostasis, is essential for any cellular function. From single cell organisms to humans, selective pressures have led to the evolution of adaptive programs that ensure proteins are properly produced and disposed of when necessary. Environmental factors such as temperature,
Bartelt, A., Widenmaier, S.B.
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Proteostasis and Neuroinflammation in Alzheimer’s Disease
Journal of Integrative NeuroscienceAlzheimer’s disease (AD) is the most common cause of dementia in older adults, marked by a gradual and irreversible deterioration of cognitive abilities, including memory and thinking skills. AD is highly heterogeneous, with variations in amyloid and tau
Augustina Potokiri, Hongmin Wang
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Proteostasis Response to Protein Misfolding in Controlled Hypertension
Cells, 2022 Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira +12 more
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Fluorodeoxyuridine improves Caenorhabditis elegans proteostasis independent of reproduction onset. [PDF]
PLoS ONE, 2014 Protein homeostasis (proteostasis) networks are dynamic throughout the lifespan of an organism. During Caenorhabditis elegans adulthood, the maintenance of metastable proteins and the activation of stress responses are inversely associated with germline ...
Naama Feldman +2 more
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Unravelling druggable signalling networks that control F508del-CFTR proteostasis
eLife, 2015 Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein.
Ramanath Narayana Hegde +15 more
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