Results 21 to 30 of about 51,687 (291)
TFEB regulates lysosomal proteostasis [PDF]
Human Molecular Genetics, 2013 Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding of the mutated variants, thereby ameliorating the disease phenotype.
Song, Wensi +6 more
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Proteostasis in Cerebral Small Vessel Disease [PDF]
Frontiers in Neuroscience, 2019 Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combination ...
Christof Haffner
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, 2023 Trabajo presentado en la International Conference on Plant Proteostasis, celebrada en el Centro Nacional de Biotecnología (Madrid), perteneciente al CSIC, entre el 21 y el 23 de septiembre de 2022.
Lois, L. María
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MicroRNAs as central regulators of adult myogenesis and proteostasis loss in skeletal muscle ageing [PDF]
, 2022 This is an Accepted Manuscript of a book chapter published by CRC Press in [Proteostasis and proteolysis] on [5/11/2021], available online: http://www.crcpress.com/9780367499327Sarcopenia (from the Greek words sarca (σάρκα) = flesh and penia (πενία ...
Kanakis, Ioannis +3 more
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Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus [PDF]
, 2021 Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmental ...
Seyfried, Nicholas T +39 more
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Hyperammonemia and proteostasis in cirrhosis [PDF]
Current Opinion in Clinical Nutrition & Metabolic Care, 2018 Skeletal muscle loss or sarcopenia is a frequent complication of cirrhosis that adversely affects clinical outcomes. As skeletal muscle is the largest store of proteins in the body, proteostasis or protein homeostasis is required for maintenance of muscle mass. This review will focus on disordered skeletal muscle proteostasis in liver disease.Increased
Srinivasan, Dasarathy, Maria, Hatzoglou
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Synaptic proteostasis in Parkinson's disease
Current Opinion in Neurobiology, 2022 There are over 7 million people worldwide suffering from Parkinson's disease, and this number will double in the next decade. Causative mutations and risk variants in >20 genes that predominantly act at synapses have been linked to Parkinson's disease. Synaptic defects precede neuronal death.
Nachman, Eliana, Verstreken, Patrik
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Hematopoietic stem cell regulation by the proteostasis network [PDF]
, 2020 Purpose of reviewProtein homeostasis (proteostasis) is maintained by an integrated network of physiological mechanisms and stress response pathways that regulate the content and quality of the proteome.
Signer, Robert AJ +3 more
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Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
Frontiers in Molecular Neuroscience, 2017 Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells.
Pamela J. Shaw +3 more
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Changes in Glutathione Redox Potential Are Linked to Aβ42-Induced Neurotoxicity
Cell Reports, 2018 Summary: Glutathione is the major low-molecular weight thiol of eukaryotic cells. It is central to one of the two major NADPH-dependent reducing systems and is likely to play a role in combating oxidative stress, a process suggested to play a key role in
Zeenna A. Stapper, Thomas R. Jahn
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