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, 2023 Trabajo presentado en la International Conference on Plant Proteostasis, celebrada en el Centro Nacional de Biotecnología (Madrid), perteneciente al CSIC, entre el 21 y el 23 de septiembre de 2022.
Lois, L. María
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The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury
Cells, 2022 Proteostasis (protein homeostasis) is critical for cellular as well as organismal survival. It is strictly regulated by multiple conserved pathways including the ubiquitin-proteasome system, autophagy, the heat shock response, the integrated stress ...
Scott R. Whittemore +4 more
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Plant proteostasis-a proven and promising target for crop improvement - Editorial [PDF]
, 2022 The Green Revolution of the 1960s accomplished dramatic increases in crop yields through genetic improvement, chemical fertilisers, irrigation, and mechanisation.
Frederica L. Theodoulou +11 more
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dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
Disease Models & Mechanisms, 2021 Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng +8 more
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Protein homeostasis in aging and cancer
Frontiers in Cell and Developmental Biology, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and
Xiao-Qiong Chen +5 more
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Hyperammonemia and proteostasis in cirrhosis [PDF]
Current Opinion in Clinical Nutrition & Metabolic Care, 2018 Skeletal muscle loss or sarcopenia is a frequent complication of cirrhosis that adversely affects clinical outcomes. As skeletal muscle is the largest store of proteins in the body, proteostasis or protein homeostasis is required for maintenance of muscle mass. This review will focus on disordered skeletal muscle proteostasis in liver disease.Increased
Srinivasan, Dasarathy, Maria, Hatzoglou
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Proteostasis Dysregulation in Pancreatic Cancer [PDF]
, 2020 The most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), has a dismal 5-year survival rate of less than 5%. Radical surgical resection, in combination with adjuvant chemotherapy, provides the best option for long-term patient ...
Arpalahti, Leena +5 more
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A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease
Cell Reports, 2014 Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, and ...
Marc Brehme +11 more
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Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]
, 2012 Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Kikhney, Alexey +24 more
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Proteostasis in T cell aging [PDF]
, 2023 Aging leads to a decline in immune cell function, which leaves the organism vulnerable to infections and age-related multimorbidities. One major player of the adaptive immune response are T cells, and recent studies argue for a major role of disturbed ...
Leng, Houfu +11 more
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