Results 21 to 30 of about 48,911 (292)
TFEB regulates lysosomal proteostasis [PDF]
Human Molecular Genetics, 2013 Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding of the mutated variants, thereby ameliorating the disease phenotype.
Song, Wensi +6 more
openaire +4 more sources
Proteostasis During Cerebral Ischemia [PDF]
Frontiers in Neuroscience, 2019 Cerebral ischemia is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation ...
Audrey M. Thiebaut +6 more
doaj +3 more sources
Proteostasis in Cerebral Small Vessel Disease [PDF]
Frontiers in Neuroscience, 2019 Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combination ...
Christof Haffner
doaj +2 more sources
, 2023 Trabajo presentado en la International Conference on Plant Proteostasis, celebrada en el Centro Nacional de Biotecnología (Madrid), perteneciente al CSIC, entre el 21 y el 23 de septiembre de 2022.
Lois, L. María
openaire +2 more sources
The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury
Cells, 2022 Proteostasis (protein homeostasis) is critical for cellular as well as organismal survival. It is strictly regulated by multiple conserved pathways including the ubiquitin-proteasome system, autophagy, the heat shock response, the integrated stress ...
Scott R. Whittemore +4 more
doaj +1 more source
dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
Disease Models & Mechanisms, 2021 Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng +8 more
doaj +1 more source
Protein homeostasis in aging and cancer
Frontiers in Cell and Developmental Biology, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and
Xiao-Qiong Chen +5 more
doaj +1 more source
Plant proteostasis-a proven and promising target for crop improvement - Editorial [PDF]
, 2022 The Green Revolution of the 1960s accomplished dramatic increases in crop yields through genetic improvement, chemical fertilisers, irrigation, and mechanisation.
Frederica L. Theodoulou +11 more
core +1 more source
MicroRNAs as central regulators of adult myogenesis and proteostasis loss in skeletal muscle ageing [PDF]
, 2022 This is an Accepted Manuscript of a book chapter published by CRC Press in [Proteostasis and proteolysis] on [5/11/2021], available online: http://www.crcpress.com/9780367499327Sarcopenia (from the Greek words sarca (σάρκα) = flesh and penia (πενία ...
Kanakis, Ioannis +3 more
core +1 more source
Proteostasis Dysregulation in Pancreatic Cancer [PDF]
, 2020 The most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), has a dismal 5-year survival rate of less than 5%. Radical surgical resection, in combination with adjuvant chemotherapy, provides the best option for long-term patient ...
Arpalahti, Leena +5 more
core +1 more source